Reviewed, UniProtKB/Swiss-Prot Q9YGY4 (HDAC9_XENLA)

Names and origin

Protein names

Recommended name:
    Histone deacetylase 9
    EC=3.5.1.98
Alternative name(s):
    Histone deacetylase-related protein
    MEF2-interacting transcription repressor MITR

Gene names

Name:	hdac9
Synonyms:	hdrp, mitr

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Ref.1
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subunit structure	Homodimer By similarity. Interacts with mef2. Ref.1
Subcellular location	Nucleus By similarity.
Tissue specificity	Broadly expressed. Ref.1
Developmental stage	Broadly expressed at low levels at all stages. Ref.1
Sequence similarities	Belongs to the histone deacetylase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Histone deacetylase 9		PRO_0000280538
Regions
	Region	172 – 222	51	Interaction with mef2

Sequences

	Sequence		Length	Mass (Da)
	Q9YGY4-1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 4E4BD92BAC605E84	FASTA	596	67,307
	10 20 30 40 50 60 MLQTIYESES YFSSDGVAGR EQLLAEQRMH AMIGKDIKSE FPIGLESISP LDLRTDLRTA 70 80 90 100 110 120 VPVGDPGLRE KQLQQELLII KQQQQIQKQL LIAEFQKQHE NLTRQHQVQL QEHLKLQQEL 130 140 150 160 170 180 LAMKQQQELL EREKEQKMEQ QRKEQEAERH RQEQQLCHPR SKDRVKERAV ASTEVKQKLQ 190 200 210 220 230 240 EFILSKSATK EPLTNGTSHS MGRHPKLWYT AAHHTSLDQS SPPPSGTSPT YKCPPPGNQD 250 260 270 280 290 300 DFPLRKTASE PNLKVRSRLK QKVVERRSSP LLRRKDSIVS SSYKKRIFEV AESSVSSSSP 310 320 330 340 350 360 VSGPSSPNNG PVAMEAEHET PVLSVNSRIE NLVSHHHLVH HERSLSLLNL YTSPSLPNIT 370 380 390 400 410 420 LGLHATATQL NTSSSLKEQQ KYDPQAPRQG VSMAGQYAGG IPTSSNHVSL EGKANSHQAI 430 440 450 460 470 480 LQHLLLKEQM RQQKILASGG TPVLHQSPLA AKDRVSPAGR VAHKLPRHRP LHRTQSAPLP 490 500 510 520 530 540 QSTLAQLVIQ QQHQQFLEKQ KQYQQQIHMN KILSKSIEQL RQPEGHLEEA EEDLHGDNLM 550 560 570 580 590 QEKSSSIDNT RSYSSTDLRT GPFGSVKVKE EPPDSENEIK THLQSEQKSV FAQQVT

References

[1]	"MEF-2 function is modified by a novel co-repressor, MITR." Sparrow D.B., Miska E.A., Langley E., Reynaud-Deonauth S., Kotecha S., Towers N., Spohr G., Kouzarides T., Mohun T.J. EMBO J. 18:5085-5098(1999) [PubMed: 10487760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MEF2, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
[2]	"Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5." Zhou X., Richon V.M., Rifkind R.A., Marks P.A. Proc. Natl. Acad. Sci. U.S.A. 97:1056-1061(2000) [PubMed: 10655483] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z97214 mRNA. Translation: CAB10167.1. Different initiation.
RefSeq	NP_001079307.1.
UniGene	Xl.227
3D structure databases
SMR	Q9YGY4. Positions 64-131.
ModBase	Search...
Genome annotation databases
GeneID	378615.
KEGG	xla:378615.
Organism-specific databases
CTD	378615.
Xenbase	XB-FEAT-488738. hdac9.
Phylogenomic databases
HOVERGEN	Q9YGY4.
Family and domain databases
InterPro	IPR000286. His_deacetylse. [Graphical view]
PANTHER	PTHR10625. His_deacetylse. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HDAC9_XENLA

Accession

Primary (citable) accession number: Q9YGY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	January 19, 2010
This is version 33 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project