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Q9YGY0

- AXIN1_XENLA

UniProt

Q9YGY0 - AXIN1_XENLA

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Protein

Axin-1

Gene

axin1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

GO - Molecular functioni

  1. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. positive regulation of JNK cascade Source: UniProtKB
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
  4. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Short name:
xAxin
Gene namesi
Name:axin1
Synonyms:axin, axn
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842Axin-1PRO_0000220892Add
BLAST

Post-translational modificationi

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9YGY0.

Expressioni

Developmental stagei

Weakly and ubiquitously expressed throughout early development, and highly expressed in the anterior mesencephalon adjacent to the forebrain-midbrain boundary.

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
apcP700392EBI-1037449,EBI-8069633

Protein-protein interaction databases

DIPiDIP-36387N.
IntActiQ9YGY0. 2 interactions.
MINTiMINT-7305491.

Structurei

Secondary structure

1
842
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi471 – 48010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QZ7X-ray2.20B435-504[»]
ProteinModelPortaliQ9YGY0.
SMRiQ9YGY0. Positions 74-219, 759-842.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YGY0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 211124RGSPROSITE-ProRule annotationAdd
BLAST
Domaini760 – 84283DIXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni348 – 43386Interaction with GSK3BBy similarityAdd
BLAST
Regioni434 – 50875Interaction with beta-cateninAdd
BLAST

Sequence similaritiesi

Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG004324.
KOiK02157.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YGY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVKGKGFPL DLGGSFTEDA PRPPVPGEEG ELITTDQRPF SHTYYSLKND
60 70 80 90 100
GIKNETSTAT PRRPDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIH
110 120 130 140 150
LFRTFLQQEN CADLLDFWFA CSGFRKLEPN DSKVEKRLKL AKAIYKKYVL
160 170 180 190 200
DSNGIVSRQI KPATKSFIKD CVLRQQIDPA MFDQAQMEIQ SMMEDNTYPV
210 220 230 240 250
FLKSDIYLEY TTIGGESPKN YSDQSSGSGT GKGPSGYLPT LNEDEEWRCD
260 270 280 290 300
QGGEHERERE CIPSSLFSQK LALDSSSHCA GSNRRLSDGR EFRPGTWREP
310 320 330 340 350
VNPYYVNTGY AGAPVTSAND SEQQSMSSDA DTMSLTDSSV DGIPPYRLRK
360 370 380 390 400
HYRREMQESA NANGRGPLPH IPRTYHMPKD IHVDPEKFAA ELISRLEGVL
410 420 430 440 450
RDREAEQKLE ERLKRVRAEE EGDDGDVSSG PSVISHKLPS GPPMHHFNSR
460 470 480 490 500
YSETGCVGMQ IRDAHEENPE SILDEHVQRV MKTPGCQSPG TGRHSPKSRS
510 520 530 540 550
PDGHLSKTLP GSLGTMQTGH GKHSSKSTAK VDSGNLHHHK HVYHHVHHHG
560 570 580 590 600
GVKPKEQIDG ESTQRVQTNF PWNVESHNYA TKSRNYAESM GMAPNPMDSL
610 620 630 640 650
AYSGKVSMLS KRNAKKADLG KSESASHEMP VVPEDSERHQ KILQWIMEGE
660 670 680 690 700
KEIIRHKKSN HSSSSAKKQP PTELARPLSI ERPGAVHPWV SAQLRNVVQP
710 720 730 740 750
SHPFIQDPTM PPNPAPNPLT QLVSKPGARL EEEEKKAAKM PQKQRLKPQK
760 770 780 790 800
KNVSAPSQPC DNIVVAYYFC GEPIPYRTMV KGRVVTLGQF KELLTKKGNY
810 820 830 840
RYYFKKVSDE FDCGVVFEEV REDDMILPIY EEKIIGQVEK ID
Length:842
Mass (Da):94,460
Last modified:May 1, 1999 - v1
Checksum:iBDA152734C97191E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097313 mRNA. Translation: AAC71036.1.
RefSeqiNP_001081874.1. NM_001088405.1.
UniGeneiXl.463.

Genome annotation databases

GeneIDi398097.
KEGGixla:398097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097313 mRNA. Translation: AAC71036.1 .
RefSeqi NP_001081874.1. NM_001088405.1.
UniGenei Xl.463.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QZ7 X-ray 2.20 B 435-504 [» ]
ProteinModelPortali Q9YGY0.
SMRi Q9YGY0. Positions 74-219, 759-842.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-36387N.
IntActi Q9YGY0. 2 interactions.
MINTi MINT-7305491.

Proteomic databases

PRIDEi Q9YGY0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398097.
KEGGi xla:398097.

Organism-specific databases

CTDi 8312.

Phylogenomic databases

HOVERGENi HBG004324.
KOi K02157.

Miscellaneous databases

EvolutionaryTracei Q9YGY0.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain."
    Hedgepeth C.M., Deardorff M.A., Klein P.S.
    Mech. Dev. 80:147-151(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex."
    Xing Y., Clements W.K., Kimelman D., Xu W.
    Genes Dev. 17:2753-2764(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 435-504 IN COMPLEX WITH HUMAN BETA-CATENIN.

Entry informationi

Entry nameiAXIN1_XENLA
AccessioniPrimary (citable) accession number: Q9YGY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3