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Q9YGY0

- AXIN1_XENLA

UniProt

Q9YGY0 - AXIN1_XENLA

Protein

Axin-1

Gene

axin1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein homodimerization activity Source: UniProtKB
    3. signal transducer activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. positive regulation of JNK cascade Source: UniProtKB
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro
    4. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Axin-1
    Alternative name(s):
    Axis inhibition protein 1
    Short name:
    xAxin
    Gene namesi
    Name:axin1
    Synonyms:axin, axn
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 842842Axin-1PRO_0000220892Add
    BLAST

    Post-translational modificationi

    Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9YGY0.

    Expressioni

    Developmental stagei

    Weakly and ubiquitously expressed throughout early development, and highly expressed in the anterior mesencephalon adjacent to the forebrain-midbrain boundary.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    apcP700392EBI-1037449,EBI-8069633

    Protein-protein interaction databases

    DIPiDIP-36387N.
    IntActiQ9YGY0. 2 interactions.
    MINTiMINT-7305491.

    Structurei

    Secondary structure

    1
    842
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi471 – 48010

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QZ7X-ray2.20B435-504[»]
    ProteinModelPortaliQ9YGY0.
    SMRiQ9YGY0. Positions 74-219, 759-842.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9YGY0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 211124RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini760 – 84283DIXPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni348 – 43386Interaction with GSK3BBy similarityAdd
    BLAST
    Regioni434 – 50875Interaction with beta-cateninAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG004324.
    KOiK02157.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9YGY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVKGKGFPL DLGGSFTEDA PRPPVPGEEG ELITTDQRPF SHTYYSLKND    50
    GIKNETSTAT PRRPDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIH 100
    LFRTFLQQEN CADLLDFWFA CSGFRKLEPN DSKVEKRLKL AKAIYKKYVL 150
    DSNGIVSRQI KPATKSFIKD CVLRQQIDPA MFDQAQMEIQ SMMEDNTYPV 200
    FLKSDIYLEY TTIGGESPKN YSDQSSGSGT GKGPSGYLPT LNEDEEWRCD 250
    QGGEHERERE CIPSSLFSQK LALDSSSHCA GSNRRLSDGR EFRPGTWREP 300
    VNPYYVNTGY AGAPVTSAND SEQQSMSSDA DTMSLTDSSV DGIPPYRLRK 350
    HYRREMQESA NANGRGPLPH IPRTYHMPKD IHVDPEKFAA ELISRLEGVL 400
    RDREAEQKLE ERLKRVRAEE EGDDGDVSSG PSVISHKLPS GPPMHHFNSR 450
    YSETGCVGMQ IRDAHEENPE SILDEHVQRV MKTPGCQSPG TGRHSPKSRS 500
    PDGHLSKTLP GSLGTMQTGH GKHSSKSTAK VDSGNLHHHK HVYHHVHHHG 550
    GVKPKEQIDG ESTQRVQTNF PWNVESHNYA TKSRNYAESM GMAPNPMDSL 600
    AYSGKVSMLS KRNAKKADLG KSESASHEMP VVPEDSERHQ KILQWIMEGE 650
    KEIIRHKKSN HSSSSAKKQP PTELARPLSI ERPGAVHPWV SAQLRNVVQP 700
    SHPFIQDPTM PPNPAPNPLT QLVSKPGARL EEEEKKAAKM PQKQRLKPQK 750
    KNVSAPSQPC DNIVVAYYFC GEPIPYRTMV KGRVVTLGQF KELLTKKGNY 800
    RYYFKKVSDE FDCGVVFEEV REDDMILPIY EEKIIGQVEK ID 842
    Length:842
    Mass (Da):94,460
    Last modified:May 1, 1999 - v1
    Checksum:iBDA152734C97191E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097313 mRNA. Translation: AAC71036.1.
    RefSeqiNP_001081874.1. NM_001088405.1.
    UniGeneiXl.463.

    Genome annotation databases

    GeneIDi398097.
    KEGGixla:398097.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097313 mRNA. Translation: AAC71036.1 .
    RefSeqi NP_001081874.1. NM_001088405.1.
    UniGenei Xl.463.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QZ7 X-ray 2.20 B 435-504 [» ]
    ProteinModelPortali Q9YGY0.
    SMRi Q9YGY0. Positions 74-219, 759-842.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-36387N.
    IntActi Q9YGY0. 2 interactions.
    MINTi MINT-7305491.

    Proteomic databases

    PRIDEi Q9YGY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 398097.
    KEGGi xla:398097.

    Organism-specific databases

    CTDi 8312.

    Phylogenomic databases

    HOVERGENi HBG004324.
    KOi K02157.

    Miscellaneous databases

    EvolutionaryTracei Q9YGY0.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain."
      Hedgepeth C.M., Deardorff M.A., Klein P.S.
      Mech. Dev. 80:147-151(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex."
      Xing Y., Clements W.K., Kimelman D., Xu W.
      Genes Dev. 17:2753-2764(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 435-504 IN COMPLEX WITH HUMAN BETA-CATENIN.

    Entry informationi

    Entry nameiAXIN1_XENLA
    AccessioniPrimary (citable) accession number: Q9YGY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3