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Q9YGY0

- AXIN1_XENLA

UniProt

Q9YGY0 - AXIN1_XENLA

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Protein

Axin-1

Gene
axin1, axin, axn
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein homodimerization activity Source: UniProtKB
  3. signal transducer activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. positive regulation of JNK cascade Source: UniProtKB
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
  4. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Short name:
xAxin
Gene namesi
Name:axin1
Synonyms:axin, axn
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842Axin-1PRO_0000220892Add
BLAST

Post-translational modificationi

Probably phosphorylated by GSK3B and dephosphorylated by PP2A By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9YGY0.

Expressioni

Developmental stagei

Weakly and ubiquitously expressed throughout early development, and highly expressed in the anterior mesencephalon adjacent to the forebrain-midbrain boundary.

Interactioni

Subunit structurei

Homodimer By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
apcP700392EBI-1037449,EBI-8069633

Protein-protein interaction databases

DIPiDIP-36387N.
IntActiQ9YGY0. 2 interactions.
MINTiMINT-7305491.

Structurei

Secondary structure

1
842
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi471 – 48010

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QZ7X-ray2.20B435-504[»]
ProteinModelPortaliQ9YGY0.
SMRiQ9YGY0. Positions 74-219, 759-842.

Miscellaneous databases

EvolutionaryTraceiQ9YGY0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 211124RGSAdd
BLAST
Domaini760 – 84283DIXAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni348 – 43386Interaction with GSK3B By similarityAdd
BLAST
Regioni434 – 50875Interaction with beta-cateninAdd
BLAST

Sequence similaritiesi

Contains 1 DIX domain.
Contains 1 RGS domain.

Phylogenomic databases

HOVERGENiHBG004324.
KOiK02157.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YGY0-1 [UniParc]FASTAAdd to Basket

« Hide

MSVKGKGFPL DLGGSFTEDA PRPPVPGEEG ELITTDQRPF SHTYYSLKND    50
GIKNETSTAT PRRPDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIH 100
LFRTFLQQEN CADLLDFWFA CSGFRKLEPN DSKVEKRLKL AKAIYKKYVL 150
DSNGIVSRQI KPATKSFIKD CVLRQQIDPA MFDQAQMEIQ SMMEDNTYPV 200
FLKSDIYLEY TTIGGESPKN YSDQSSGSGT GKGPSGYLPT LNEDEEWRCD 250
QGGEHERERE CIPSSLFSQK LALDSSSHCA GSNRRLSDGR EFRPGTWREP 300
VNPYYVNTGY AGAPVTSAND SEQQSMSSDA DTMSLTDSSV DGIPPYRLRK 350
HYRREMQESA NANGRGPLPH IPRTYHMPKD IHVDPEKFAA ELISRLEGVL 400
RDREAEQKLE ERLKRVRAEE EGDDGDVSSG PSVISHKLPS GPPMHHFNSR 450
YSETGCVGMQ IRDAHEENPE SILDEHVQRV MKTPGCQSPG TGRHSPKSRS 500
PDGHLSKTLP GSLGTMQTGH GKHSSKSTAK VDSGNLHHHK HVYHHVHHHG 550
GVKPKEQIDG ESTQRVQTNF PWNVESHNYA TKSRNYAESM GMAPNPMDSL 600
AYSGKVSMLS KRNAKKADLG KSESASHEMP VVPEDSERHQ KILQWIMEGE 650
KEIIRHKKSN HSSSSAKKQP PTELARPLSI ERPGAVHPWV SAQLRNVVQP 700
SHPFIQDPTM PPNPAPNPLT QLVSKPGARL EEEEKKAAKM PQKQRLKPQK 750
KNVSAPSQPC DNIVVAYYFC GEPIPYRTMV KGRVVTLGQF KELLTKKGNY 800
RYYFKKVSDE FDCGVVFEEV REDDMILPIY EEKIIGQVEK ID 842
Length:842
Mass (Da):94,460
Last modified:May 1, 1999 - v1
Checksum:iBDA152734C97191E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097313 mRNA. Translation: AAC71036.1.
RefSeqiNP_001081874.1. NM_001088405.1.
UniGeneiXl.463.

Genome annotation databases

GeneIDi398097.
KEGGixla:398097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097313 mRNA. Translation: AAC71036.1 .
RefSeqi NP_001081874.1. NM_001088405.1.
UniGenei Xl.463.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QZ7 X-ray 2.20 B 435-504 [» ]
ProteinModelPortali Q9YGY0.
SMRi Q9YGY0. Positions 74-219, 759-842.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-36387N.
IntActi Q9YGY0. 2 interactions.
MINTi MINT-7305491.

Proteomic databases

PRIDEi Q9YGY0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398097.
KEGGi xla:398097.

Organism-specific databases

CTDi 8312.

Phylogenomic databases

HOVERGENi HBG004324.
KOi K02157.

Miscellaneous databases

EvolutionaryTracei Q9YGY0.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain."
    Hedgepeth C.M., Deardorff M.A., Klein P.S.
    Mech. Dev. 80:147-151(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex."
    Xing Y., Clements W.K., Kimelman D., Xu W.
    Genes Dev. 17:2753-2764(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 435-504 IN COMPLEX WITH HUMAN BETA-CATENIN.

Entry informationi

Entry nameiAXIN1_XENLA
AccessioniPrimary (citable) accession number: Q9YGY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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