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Q9YGY0 (AXIN1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Short name=xAxin
Gene names
Name:axin1
Synonyms:axin, axn
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length842 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Developmental stage

Weakly and ubiquitously expressed throughout early development, and highly expressed in the anterior mesencephalon adjacent to the forebrain-midbrain boundary.

Post-translational modification

Probably phosphorylated by GSK3B and dephosphorylated by PP2A By similarity.

Sequence similarities

Contains 1 DIX domain.

Contains 1 RGS domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

apcP700392EBI-1037449,EBI-8069633

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 842842Axin-1
PRO_0000220892

Regions

Domain88 – 211124RGS
Domain760 – 84283DIX
Region348 – 43386Interaction with GSK3B By similarity
Region434 – 50875Interaction with beta-catenin

Secondary structure

... 842
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9YGY0 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: BDA152734C97191E

FASTA84294,460
        10         20         30         40         50         60 
MSVKGKGFPL DLGGSFTEDA PRPPVPGEEG ELITTDQRPF SHTYYSLKND GIKNETSTAT 

        70         80         90        100        110        120 
PRRPDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIH LFRTFLQQEN CADLLDFWFA 

       130        140        150        160        170        180 
CSGFRKLEPN DSKVEKRLKL AKAIYKKYVL DSNGIVSRQI KPATKSFIKD CVLRQQIDPA 

       190        200        210        220        230        240 
MFDQAQMEIQ SMMEDNTYPV FLKSDIYLEY TTIGGESPKN YSDQSSGSGT GKGPSGYLPT 

       250        260        270        280        290        300 
LNEDEEWRCD QGGEHERERE CIPSSLFSQK LALDSSSHCA GSNRRLSDGR EFRPGTWREP 

       310        320        330        340        350        360 
VNPYYVNTGY AGAPVTSAND SEQQSMSSDA DTMSLTDSSV DGIPPYRLRK HYRREMQESA 

       370        380        390        400        410        420 
NANGRGPLPH IPRTYHMPKD IHVDPEKFAA ELISRLEGVL RDREAEQKLE ERLKRVRAEE 

       430        440        450        460        470        480 
EGDDGDVSSG PSVISHKLPS GPPMHHFNSR YSETGCVGMQ IRDAHEENPE SILDEHVQRV 

       490        500        510        520        530        540 
MKTPGCQSPG TGRHSPKSRS PDGHLSKTLP GSLGTMQTGH GKHSSKSTAK VDSGNLHHHK 

       550        560        570        580        590        600 
HVYHHVHHHG GVKPKEQIDG ESTQRVQTNF PWNVESHNYA TKSRNYAESM GMAPNPMDSL 

       610        620        630        640        650        660 
AYSGKVSMLS KRNAKKADLG KSESASHEMP VVPEDSERHQ KILQWIMEGE KEIIRHKKSN 

       670        680        690        700        710        720 
HSSSSAKKQP PTELARPLSI ERPGAVHPWV SAQLRNVVQP SHPFIQDPTM PPNPAPNPLT 

       730        740        750        760        770        780 
QLVSKPGARL EEEEKKAAKM PQKQRLKPQK KNVSAPSQPC DNIVVAYYFC GEPIPYRTMV 

       790        800        810        820        830        840 
KGRVVTLGQF KELLTKKGNY RYYFKKVSDE FDCGVVFEEV REDDMILPIY EEKIIGQVEK 


ID 

« Hide

References

[1]"Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain."
Hedgepeth C.M., Deardorff M.A., Klein P.S.
Mech. Dev. 80:147-151(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex."
Xing Y., Clements W.K., Kimelman D., Xu W.
Genes Dev. 17:2753-2764(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 435-504 IN COMPLEX WITH HUMAN BETA-CATENIN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF097313 mRNA. Translation: AAC71036.1.
RefSeqNP_001081874.1. NM_001088405.1.
UniGeneXl.463.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QZ7X-ray2.20B435-504[»]
ProteinModelPortalQ9YGY0.
SMRQ9YGY0. Positions 74-219, 759-842.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-36387N.
IntActQ9YGY0. 2 interactions.
MINTMINT-7305491.

Proteomic databases

PRIDEQ9YGY0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID398097.
KEGGxla:398097.

Organism-specific databases

CTD8312.

Phylogenomic databases

HOVERGENHBG004324.
KOK02157.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9YGY0.

Entry information

Entry nameAXIN1_XENLA
AccessionPrimary (citable) accession number: Q9YGY0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references