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Protein
Submitted name:

Potassium channel Shaker cKv1.4

Gene

KCNA4

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-GGA-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel Shaker cKv1.4Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:KCNA4Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei324 – 34219HelicalSequence analysisAdd
BLAST
Transmembranei487 – 50822HelicalSequence analysisAdd
BLAST
Transmembranei548 – 56922HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019808.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 292101BTB (POZ)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1545. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
KOiK04877.
OMAiKKAHHRQ.
OrthoDBiEOG7M0NRD.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
1.20.5.600. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR020467. K_chnl_volt-dep_Kv1.4.
IPR012897. K_chnl_volt-dep_Kv1.4_TID.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF07941. K_channel_TID. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01511. KV14CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YGX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAMVSADS SGCNSHMPYG YAVQARARER ERLAQSRAAA AAAVAAATAA
60 70 80 90 100
VEGGATGGGG PYHHYHQEQG RGASSSHGGN ASRSSLPNRQ SGKRWKKGKK
110 120 130 140 150
RSHHLGSREC GASFPCSELL PLSGSEERIL KDVSEEEEED EDEDEDDEEE
160 170 180 190 200
GKLYYSADYG EDEFSYSDQP PDDGGGPGGY SSVRYSEYEC CERVVINVSG
210 220 230 240 250
LRFETQLKTL AQFPETLLGD PAKRGRYFDP LRNEYFFDRN RPSFDAILYY
260 270 280 290 300
YQSGGRLKRP VNVPFDIFSE EVKFYQLGEE AMLKFREDEG FVKEEEDKAL
310 320 330 340 350
PENEFKRQVW LLFEYPESSS PARGIAIVSV LVILISIVIF CLETLPEFRD
360 370 380 390 400
DKEFIMSLSS GKGISNESLH LDDGEHTIFN DPFFIVETVC IIWFSFEFTV
410 420 430 440 450
RCFACPSKAH FLKNIMNIID IVSILPYFIT LGTDLVQEQG SNGQQAMSFA
460 470 480 490 500
ILRIIRLVRV FRIFKLSRHS KGLQILGHTL RASMRELGLL IFFLFIGVIL
510 520 530 540 550
FSSAVYFAEA DEPATHFQSI PDAFWWAVVT MTTVGYGDMK PITVGGKIVG
560 570 580 590 600
SLCAIAGVLT IALPVPVIVS NFNYFYHRET ENEEQTQLMQ NAVSCPYLPT
610 620 630 640 650
NLLKKFRSSS SSSTEDKSEY LEMEEGVKES LCVKEKKSQD TGNSSESEKK
660
NCVNSNSVET DV
Length:662
Mass (Da):74,061
Last modified:May 1, 1999 - v1
Checksum:i7DB994240DF58007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03004449 Genomic DNA. No translation available.
U82365 mRNA. Translation: AAD11454.1.
RefSeqiNP_990230.2. NM_204899.2.
UniGeneiGga.422.

Genome annotation databases

EnsembliENSGALT00000019835; ENSGALP00000019808; ENSGALG00000012142.
GeneIDi395721.
KEGGigga:395721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03004449 Genomic DNA. No translation available.
U82365 mRNA. Translation: AAD11454.1.
RefSeqiNP_990230.2. NM_204899.2.
UniGeneiGga.422.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000019835; ENSGALP00000019808; ENSGALG00000012142.
GeneIDi395721.
KEGGigga:395721.

Organism-specific databases

CTDi3739.

Phylogenomic databases

eggNOGiKOG1545. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
KOiK04877.
OMAiKKAHHRQ.
OrthoDBiEOG7M0NRD.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-GGA-1296072. Voltage gated Potassium channels.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
1.20.5.600. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR020467. K_chnl_volt-dep_Kv1.4.
IPR012897. K_chnl_volt-dep_Kv1.4_TID.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF07941. K_channel_TID. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01511. KV14CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Rajeevan M., Hu S., Sokolowski B.H.A.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Cloning and expression of Shaker alpha- and beta-subunits during inner ear development."
    Rajeevan M.S., Hu S., Sakai Y., Sokolowski B.H.A.
    Brain Res. Mol. Brain Res. 66:83-93(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiQ9YGX8_CHICK
AccessioniPrimary (citable) accession number: Q9YGX8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.