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Q9YGW6

- Q9YGW6_CHICK

UniProt

Q9YGW6 - Q9YGW6_CHICK

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Protein
Submitted name:

Ezrin

Gene

EZR

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. actin filament binding Source: UniProtKB
  2. cell adhesion molecule binding Source: BHF-UCL
  3. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. actin filament bundle assembly Source: UniProtKB
  2. establishment of endothelial barrier Source: Ensembl
  3. establishment or maintenance of apical/basal cell polarity Source: Ensembl
  4. leukocyte cell-cell adhesion Source: Ensembl
  5. membrane to membrane docking Source: Ensembl
  6. positive regulation of gene expression Source: Ensembl
  7. receptor internalization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
EzrinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:EZRImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 3

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: UniProtKB
  2. actin filament Source: UniProtKB
  3. apical plasma membrane Source: Ensembl
  4. ciliary basal body Source: Ensembl
  5. cytosol Source: Ensembl
  6. extracellular space Source: Ensembl
  7. extracellular vesicular exosome Source: Ensembl
  8. extrinsic component of membrane Source: UniProtKB
  9. filopodium Source: Ensembl
  10. focal adhesion Source: Ensembl
  11. microvillus Source: Ensembl
  12. nucleolus Source: Ensembl
  13. ruffle Source: Ensembl
  14. uropod Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9YGW6.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022293.

Structurei

3D structure databases

ProteinModelPortaliQ9YGW6.
SMRiQ9YGW6. Positions 1-325, 499-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains FERM domain.SAAS annotation

Phylogenomic databases

eggNOGiNOG236035.
GeneTreeiENSGT00760000119078.
HOGENOMiHOG000007113.
HOVERGENiHBG002185.
KOiK08007.
OrthoDBiEOG7BGHK6.
PhylomeDBiQ9YGW6.
TreeFamiTF313935.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin_like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YGW6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKPINVRVV TVDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLQYV
60 70 80 90 100
DNKGFQTWLK LDKKVSAQEI RKENPLQFRF RAKFFPEDVA EELIQDITQK
110 120 130 140 150
LFFLQVKEGI LSDEIYCPPE TAVLLGSYAV QAKFGDYNKD VHKPGYLNSE
160 170 180 190 200
RLIPQRVMDQ HKLSRDQWEE RIQVWHAEHS GMLKENAMLE YLKIAQDLEM
210 220 230 240 250
YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF PWSEIRNISF
260 270 280 290 300
NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI
310 320 330 340 350
EVQQMKAQAR EEKHQKQLER QQLENEKKKR ETIEREKEQM LREKEELLVR
360 370 380 390 400
LQEYEVKTKR AEKELSDQIQ RALQLEEERR RAQEEAERLE ADRLAALQAK
410 420 430 440 450
EELERQNIDQ IKSQEQLAAE LAEYTAKIAL LEEARKRKES EVEEWQIRAR
460 470 480 490 500
EAQEDLVKTK EELHLVMTAP PPPPPIYEPV NYHVHDNLHD EGSEYSAYSA
510 520 530 540 550
EFSSEGIRND RNEEKRITEA EKNERVQRQL KALTDELAQA RDEDKRTQND
560 570 580
IIHSENVRQG RDKYKTLRQI RQGNTKQRID EFEAM
Length:585
Mass (Da):69,367
Last modified:May 1, 1999 - v1
Checksum:i854C6348F783CAEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03003294 Genomic DNA. No translation available.
AB019790 mRNA. Translation: BAA75497.1.
RefSeqiNP_990216.1. NM_204885.1.
UniGeneiGga.40252.

Genome annotation databases

EnsembliENSGALT00000022333; ENSGALP00000022293; ENSGALG00000013742.
GeneIDi395701.
KEGGigga:395701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03003294 Genomic DNA. No translation available.
AB019790 mRNA. Translation: BAA75497.1 .
RefSeqi NP_990216.1. NM_204885.1.
UniGenei Gga.40252.

3D structure databases

ProteinModelPortali Q9YGW6.
SMRi Q9YGW6. Positions 1-325, 499-585.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000022293.

Proteomic databases

PaxDbi Q9YGW6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000022333 ; ENSGALP00000022293 ; ENSGALG00000013742 .
GeneIDi 395701.
KEGGi gga:395701.

Organism-specific databases

CTDi 7430.

Phylogenomic databases

eggNOGi NOG236035.
GeneTreei ENSGT00760000119078.
HOGENOMi HOG000007113.
HOVERGENi HBG002185.
KOi K08007.
OrthoDBi EOG7BGHK6.
PhylomeDBi Q9YGW6.
TreeFami TF313935.

Miscellaneous databases

NextBioi 20815771.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin_like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_like_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF002305. ERM. 1 hit.
PRINTSi PR00935. BAND41.
PR00661. ERMFAMILY.
SMARTi SM00295. B41. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Specific expression of ezrin, a cytoskeletal-membrane linker protein, in a subset of chick retinotectal and sensory projections."
    Takahashi M., Yamagata M., Noda M.
    Eur. J. Neurosci. 11:545-558(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: White LeghornImported.
    Tissue: BrainImported.
  2. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiQ9YGW6_CHICK
AccessioniPrimary (citable) accession number: Q9YGW6
Secondary accession number(s): F1P3H9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3