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Q9YGW6

- Q9YGW6_CHICK

UniProt

Q9YGW6 - Q9YGW6_CHICK

Protein
Submitted name:

Ezrin

Gene

EZR

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. actin filament binding Source: UniProtKB
    2. cell adhesion molecule binding Source: BHF-UCL

    GO - Biological processi

    1. actin filament bundle assembly Source: UniProtKB
    2. establishment or maintenance of apical/basal cell polarity Source: Ensembl
    3. leukocyte cell-cell adhesion Source: Ensembl
    4. membrane to membrane docking Source: Ensembl
    5. receptor internalization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    EzrinImported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:EZRImported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. actin filament Source: UniProtKB
    3. apical plasma membrane Source: Ensembl
    4. cytosol Source: Ensembl
    5. extrinsic component of membrane Source: UniProtKB
    6. filopodium Source: Ensembl
    7. focal adhesion Source: Ensembl
    8. microvillus Source: Ensembl
    9. nucleolus Source: Ensembl
    10. ruffle Source: Ensembl
    11. uropod Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PaxDbiQ9YGW6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000022293.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9YGW6.
    SMRiQ9YGW6. Positions 1-325, 499-585.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains FERM domain.SAAS annotation

    Phylogenomic databases

    eggNOGiNOG236035.
    GeneTreeiENSGT00650000092953.
    HOGENOMiHOG000007113.
    HOVERGENiHBG002185.
    InParanoidiQ9YGW6.
    KOiK08007.
    OrthoDBiEOG7BGHK6.
    PhylomeDBiQ9YGW6.
    TreeFamiTF313935.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR011174. ERM.
    IPR011259. ERM_C_dom.
    IPR000798. Ez/rad/moesin_like.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR008954. Moesin_tail.
    IPR011993. PH_like_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00769. ERM. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002305. ERM. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00661. ERMFAMILY.
    SMARTiSM00295. B41. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF48678. SSF48678. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9YGW6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKPINVRVV TVDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLQYV    50
    DNKGFQTWLK LDKKVSAQEI RKENPLQFRF RAKFFPEDVA EELIQDITQK 100
    LFFLQVKEGI LSDEIYCPPE TAVLLGSYAV QAKFGDYNKD VHKPGYLNSE 150
    RLIPQRVMDQ HKLSRDQWEE RIQVWHAEHS GMLKENAMLE YLKIAQDLEM 200
    YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF PWSEIRNISF 250
    NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI 300
    EVQQMKAQAR EEKHQKQLER QQLENEKKKR ETIEREKEQM LREKEELLVR 350
    LQEYEVKTKR AEKELSDQIQ RALQLEEERR RAQEEAERLE ADRLAALQAK 400
    EELERQNIDQ IKSQEQLAAE LAEYTAKIAL LEEARKRKES EVEEWQIRAR 450
    EAQEDLVKTK EELHLVMTAP PPPPPIYEPV NYHVHDNLHD EGSEYSAYSA 500
    EFSSEGIRND RNEEKRITEA EKNERVQRQL KALTDELAQA RDEDKRTQND 550
    IIHSENVRQG RDKYKTLRQI RQGNTKQRID EFEAM 585
    Length:585
    Mass (Da):69,367
    Last modified:May 1, 1999 - v1
    Checksum:i854C6348F783CAEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03003294 Genomic DNA. No translation available.
    AB019790 mRNA. Translation: BAA75497.1.
    RefSeqiNP_990216.1. NM_204885.1.
    UniGeneiGga.40252.

    Genome annotation databases

    EnsembliENSGALT00000022333; ENSGALP00000022293; ENSGALG00000013742.
    GeneIDi395701.
    KEGGigga:395701.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03003294 Genomic DNA. No translation available.
    AB019790 mRNA. Translation: BAA75497.1 .
    RefSeqi NP_990216.1. NM_204885.1.
    UniGenei Gga.40252.

    3D structure databases

    ProteinModelPortali Q9YGW6.
    SMRi Q9YGW6. Positions 1-325, 499-585.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000022293.

    Proteomic databases

    PaxDbi Q9YGW6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000022333 ; ENSGALP00000022293 ; ENSGALG00000013742 .
    GeneIDi 395701.
    KEGGi gga:395701.

    Organism-specific databases

    CTDi 7430.

    Phylogenomic databases

    eggNOGi NOG236035.
    GeneTreei ENSGT00650000092953.
    HOGENOMi HOG000007113.
    HOVERGENi HBG002185.
    InParanoidi Q9YGW6.
    KOi K08007.
    OrthoDBi EOG7BGHK6.
    PhylomeDBi Q9YGW6.
    TreeFami TF313935.

    Miscellaneous databases

    NextBioi 20815771.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR011174. ERM.
    IPR011259. ERM_C_dom.
    IPR000798. Ez/rad/moesin_like.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR008954. Moesin_tail.
    IPR011993. PH_like_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00769. ERM. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002305. ERM. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00661. ERMFAMILY.
    SMARTi SM00295. B41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF48678. SSF48678. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Specific expression of ezrin, a cytoskeletal-membrane linker protein, in a subset of chick retinotectal and sensory projections."
      Takahashi M., Yamagata M., Noda M.
      Eur. J. Neurosci. 11:545-558(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: White LeghornImported.
      Tissue: BrainImported.
    2. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
      International Chicken Genome Sequencing Consortium
      Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
      , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
      Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Red jungle fowlImported.
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Red jungle fowlImported.

    Entry informationi

    Entry nameiQ9YGW6_CHICK
    AccessioniPrimary (citable) accession number: Q9YGW6
    Secondary accession number(s): F1P3H9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3