Reviewed, UniProtKB/Swiss-Prot Q9YGT6 (HXA5A_DANRE)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A5a

Gene names

Name:

hoxa5a

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Homeobox protein Hox-A5a		PRO_0000200062
Regions
	DNA binding	190 – 249	60	Homeobox
	Motif	171 – 176	6	Antp-type hexapeptide
	Compositional bias	91 – 148	58	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9YGT6-1 [UniParc]. Last modified July 11, 2006. Version 2. Checksum: 51E0738377E18CB0	FASTA	265	29,526
	10 20 30 40 50 60 MSSYFVNSFC GRYPNGVDYP LHNYGDHNSS GQCRDSTGMH SGRYACGYNG MDLSTGHSSP 70 80 90 100 110 120 GHFLSSGERT QSYKDSPTAT PVRYNQPVTA SSAEPSSDHL PCSSLANSPV SEQSHRALKI 130 140 150 160 170 180 SLSSTAGSAS KSFGTVLSRE GVSKVSSSME EEKPPGSGQT ASQNVSEAPQ IYPWMRKLHI 190 200 210 220 230 240 SHDNLAGPEG KRPRTAYTRY QTLELEKEFH FNRYLTRRRR IEIAHTLCLS ERQIKIWFQN 250 260 RRMKWKKDNK LKSMNMAAAG SGYRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	"Zebrafish hox clusters and vertebrate genome evolution." Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K., Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M., Postlethwait J.H. Science 282:1711-1714(1998) [PubMed: 9831563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-265.
[3]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed: 16174031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 104-191. Strain: Tuebingen.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382300 Genomic DNA. Translation: CAK10849.1. AF071247 Genomic DNA. Translation: AAD15940.1. Different initiation. DQ060534 mRNA. Translation: AAY67912.1.
IPI	IPI00485489.
RefSeq	NP_571615.1.
UniGene	Dr.134275
3D structure databases
SMR	Q9YGT6. Positions 191-252.
ModBase	Search...
Genome annotation databases
Ensembl	ENSDART00000003506; ENSDARP00000023754; ENSDARG00000001784; Danio rerio. [Genome view]
GeneID	58055.
KEGG	dre:58055.
Organism-specific databases
CTD	58055.
ZFIN	ZDB-GENE-000823-9. hoxa5a.
Phylogenomic databases
HOGENOM	Q9YGT6.
HOVERGEN	Q9YGT6.
OMA	TEPRYNQ
OrthoDB	EOG9PCDB9
Gene expression databases
ArrayExpress	Q9YGT6.
Bgee	Q9YGT6.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA5A_DANRE

Accession

Primary (citable) accession number: Q9YGT6
Secondary accession number(s): Q1L971, Q4PRA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 11, 2006
Last modified:	November 24, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project