Reviewed, UniProtKB/Swiss-Prot Q9YGT5 (HXA9B_DANRE)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A9b

Gene names

Name:	hoxa9b
ORF Names:	zgc:110504

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence AAD15942.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAD59109.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription activator activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Homeobox protein Hox-A9b		PRO_0000200085
Regions
	DNA binding	187 – 246	60	Homeobox
Experimental info
	Sequence conflict	15	1	I → L in AAD15942. Ref.1
	Sequence conflict	178	1	S → L in AAD15942. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9YGT5-1 [UniParc]. Last modified March 18, 2008. Version 3. Checksum: 144CD38DB6A77139	FASTA	253	28,795
	10 20 30 40 50 60 MSTLGTLSYY ADSHIPHEND DHLAPRFSSG PVVQQQSREL TLLEYSEQEP YTFQAKSSIF 70 80 90 100 110 120 GASWSPVQPT GASIAYHPYI HHPCSTGDSD GASVRPWALE PLPALPFTGL STDTHQDIKL 130 140 150 160 170 180 EPLVGSGECT THTLLVAETD NNTTQTERKV PDDAVSNGSH DEKIPAETKL DLDPNNPSSN 190 200 210 220 230 240 WLHAKSTRKK RCPYTKHQTL ELEKEFLFNM YLSRDRRYEV ARLLNLTERQ VKIWFQNRRM 250 KMKKCNKDRP KDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Zebrafish hox clusters and vertebrate genome evolution." Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K., Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M., Postlethwait J.H. Science 282:1711-1714(1998) [PubMed: 9831563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB.
[3]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[4]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed: 16174031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-181. Strain: Tuebingen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF071249 Genomic DNA. Translation: AAD15942.1. Sequence problems. AL645795 Genomic DNA. Translation: CAD59109.1. Sequence problems. BC095300 mRNA. Translation: AAH95300.1. DQ060537 mRNA. Translation: AAY67915.1.
IPI	IPI00498950.
RefSeq	NP_571608.1.
UniGene	Dr.88308
3D structure databases
SMR	Q9YGT5. Positions 180-256.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9YGT5.
Genome annotation databases
Ensembl	ENSDART00000079383; ENSDARP00000073839; ENSDARG00000056819; Danio rerio. [Genome view]
GeneID	58048.
KEGG	dre:58048.
Organism-specific databases
CTD	58048.
ZFIN	ZDB-GENE-000823-2. hoxa9b.
Phylogenomic databases
HOGENOM	HBG714137.
HOVERGEN	Q9YGT5.
Gene expression databases
Bgee	Q9YGT5.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR006711. Hox9_act. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF04617. Hox9_act. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA9B_DANRE

Accession

Primary (citable) accession number: Q9YGT5
Secondary accession number(s): Q4PRA6, Q503J9, Q8AWY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 18, 2008
Last modified:	December 15, 2009
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project