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Reviewed, UniProtKB/Swiss-Prot Q9YGL9 (AT2A3_CHICK)

Last modified February 9, 2010. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
      Short name=SR Ca(2+)-ATPase 3
      Short name=ChkSERCA3
      Short name=SERCA3
    EC=3.6.3.8
Alternative name(s):
    Calcium pump 3
Gene names
Name: ATP2A3
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

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Protein attributes

Sequence length1042 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

Catalytic activity

ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans).

Subcellular location

Nucleus membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Sarcoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Found in spleen, lung, intestine and brain.

Induction

Down-regulated by 1,25-dihydroxyvitamin D3.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type IIA subfamily.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform SERCA3B (identifier: Q9YGL9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform SERCA3A (identifier: Q9YGL9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     995-1042: ILRTVRNTWSGEHQLKTCRTPEQGRRGQEMNDTKEMLQAKGPQTCNSD → EEDKK

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10421042Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
PRO_0000046206

Regions

Topological domain1 – 4848Cytoplasmic By similarity
Transmembrane49 – 69211 By similarity
Topological domain70 – 8920Lumenal By similarity
Transmembrane90 – 110212 By similarity
Topological domain111 – 253143Cytoplasmic By similarity
Transmembrane254 – 273203 By similarity
Topological domain274 – 29522Lumenal By similarity
Transmembrane296 – 313184 By similarity
Topological domain314 – 757444Cytoplasmic By similarity
Transmembrane758 – 777205 By similarity
Topological domain778 – 78710Lumenal By similarity
Transmembrane788 – 808216 By similarity
Topological domain809 – 82820Cytoplasmic By similarity
Transmembrane829 – 851237 By similarity
Topological domain852 – 89746Lumenal By similarity
Transmembrane898 – 917208 By similarity
Topological domain918 – 93013Cytoplasmic By similarity
Transmembrane931 – 949199 By similarity
Topological domain950 – 96415Lumenal By similarity
Transmembrane965 – 9852110 By similarity
Topological domain986 – 104257Cytoplasmic By similarity

Sites

Active site35114-aspartylphosphate intermediate By similarity
Metal binding3041Calcium 2; via carbonyl oxygen By similarity
Metal binding3051Calcium 2; via carbonyl oxygen By similarity
Metal binding3071Calcium 2; via carbonyl oxygen By similarity
Metal binding3091Calcium 2 By similarity
Metal binding7031Magnesium By similarity
Metal binding7071Magnesium By similarity
Metal binding7681Calcium 1 By similarity
Metal binding7711Calcium 1 By similarity
Metal binding7961Calcium 2 By similarity
Metal binding7991Calcium 1 By similarity
Metal binding8001Calcium 1 By similarity
Metal binding8001Calcium 2 By similarity
Metal binding9081Calcium 1 By similarity
Binding site5151ATP By similarity

Natural variations

Alternative sequence995 – 104248ILRTV…TCNSD → EEDKK in isoform SERCA3A.
VSP_000371

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Sequences

Sequence LengthMass (Da)Tools
Isoform SERCA3B [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 3777E0B79311801C

FASTA1,042115,429
        10         20         30         40         50         60 
MEAAHSVPVQ DVLSRFGVAE SCGLSPEQVR RNREKYGPNE LPAEERKSLW ELVLEQFEDL 

        70         80         90        100        110        120 
LVRILLMAAF LSFILAWFEE GEESTTAFVE PIVIIMILIA NAVVGVWQER NAESAIEALK 

       130        140        150        160        170        180 
EYEPEMGKVI RADRSGVQRI RARDIVPGDI VEVAVGDKVP ADIRIIEIRS TTLRVDQSIL 

       190        200        210        220        230        240 
TGESMSVIKH ADPIPDPRAV NQDKKNMLFS GTNIAAGKAV GIVIATGVYT EIGKIRNQMV 

       250        260        270        280        290        300 
ETEPEKTPLQ QKLDEFSQQL SKVIFLVCIA VWVINISHFS DPVHGGSWFR GAIYYFKTSV 

       310        320        330        340        350        360 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 

       370        380        390        400        410        420 
MSVCRMFIME KVEGTQCSLH EFSITGSTYA PEGQILKDEK PVRCGQYDGL VELATICALC 

       430        440        450        460        470        480 
NDSSLDYNES KKVYEKVGEA TETALTCLVE KMNVFDTDTS KLSKVERANA CNSVIKHLMR 

       490        500        510        520        530        540 
KECTLEFSRD RKSMSVYCTP TGPGHNSAGS KMFVKGAPES VIERCTHVRV GTAKVPLTPP 

       550        560        570        580        590        600 
VREKILSQIR DWGMGTDTLR CLALATHDAP VQRETMQLHD STTFTHYETN LTFVGCVGML 

       610        620        630        640        650        660 
DPPRKEVTSS IEMCRKAGIR VIMITGDNKG TAVAICRRIG IFTESEDVAG KAYTGREFDE 

       670        680        690        700        710        720 
LSPEAQRQAC REARCFARVE PAHKSRIVEY LQSFNEITAM TGDGVNDAPA LKKAEIGIAM 

       730        740        750        760        770        780 
GSGTAVAKSA AEMVLSDDNF STIVSAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAI 

       790        800        810        820        830        840 
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDKL PRNPKEPLIS GWLFFRYLAI 

       850        860        870        880        890        900 
GVYVGLATVG AATWWFLYDA EGPQVSFHQL RNFMRCTEDN PIFEGVNCEI FESRYPTTMA 

       910        920        930        940        950        960 
LSVLVTIEMC NALNSVSENQ SLLRMPPWLN IWLLGAIVMS MALHFFILYV KPMPLIFQVT 

       970        980        990       1000       1010       1020 
PLSWPQWVVV LKISLPVILL DEGLKYLSRN HLEGILRTVR NTWSGEHQLK TCRTPEQGRR 

      1030       1040 
GQEMNDTKEM LQAKGPQTCN SD

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Isoform SERCA3A.

Checksum: 53A3FFE8CEFC54CE
Show »

FASTA999110,546

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References

[1]"Identification of avian sarcoplasmic reticulum Ca(2+)-ATPase (SERCA3) as a novel 1,25(OH)(2)D(3) target gene in the monocytic lineage."
Machuca I., Domenget C., Jurdic P.
Exp. Cell Res. 250:364-375(1999) [PubMed: 10413590] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SERCA3A AND SERCA3B).
Strain: SPAFAS.
Tissue: Macrophage.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y18063 mRNA. Translation: CAB38029.1.
IPIIPI00582754.
IPI00599579.
RefSeqNP_990222.1.
UniGeneGga.16523

3D structure databases

SMRQ9YGL9. Positions 1-994.
ModBaseSearch...

Proteomic databases

PRIDEQ9YGL9.

Genome annotation databases

EnsemblENSGALT00000002375; ENSGALP00000002373; ENSGALG00000001564; Gallus gallus. [Genome view]
ENSGALT00000040410; ENSGALP00000039609; ENSGALG00000001564; Gallus gallus. [Genome view]
GeneID395707.
KEGGgga:395707.

Organism-specific databases

CTD395707.

Phylogenomic databases

eggNOGveNOG07086.
HOGENOMHBG456486.
HOVERGENQ9YGL9.
InParanoidQ9YGL9.
PhylomeDBQ9YGL9.

Enzyme and pathway databases

BRENDA3.6.3.8. 4.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR005782. ATPase_P-typ_Ca-transp.
IPR006069. ATPase_P-typ_cation-exchng_asu.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00121. NAKATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 4 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAT2A3_CHICK
AccessionPrimary (citable) accession number: Q9YGL9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: February 9, 2010
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents