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Q9YGL7

- PIT1_CHICK

UniProt

Q9YGL7 - PIT1_CHICK

Protein

Pituitary-specific positive transcription factor 1

Gene

POU1F1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    • Comment

    Functioni

    Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi285 – 34460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pituitary-specific positive transcription factor 1
    Short name:
    PIT-1
    Alternative name(s):
    Growth hormone factor 1
    Short name:
    GHF-1
    Gene namesi
    Name:POU1F1
    Synonyms:PIT1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Pituitary-specific positive transcription factor 1PRO_0000100703Add
    BLAST

    Proteomic databases

    PaxDbiQ9YGL7.

    Expressioni

    Tissue specificityi

    Pituitary gland.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9YGL7.
    SMRiQ9YGL7. Positions 200-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini195 – 26975POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241031.
    HOGENOMiHOG000116302.
    HOVERGENiHBG053120.
    InParanoidiQ9YGL7.
    PhylomeDBiQ9YGL7.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR015586. Pit_1.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PANTHERiPTHR11636:SF82. PTHR11636:SF82. 1 hit.
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform PIT-1beta* (identifier: Q9YGL7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTCQAFASSD NFVPLNSDSS PSLPLIMHHS AGECLPVSNH ATNVVSTVPS    50
    VLSLIQTPKC SHFHFAMMTS GNVSAGLHYS VPSCHYGNQA STYGVMAGIK 100
    PATPEMLSAS LSQSRILQTC SMPHPNVVNG VSTLQSSLTP CLYKFPEHAL 150
    SASSCALGHS FTPMHQTLLS DDPTASDFKQ EFRRKSKSVE EPVDMDSPEI 200
    RELEKFANEF KLRRIKLGYT QTNVGEALAA VHGSEFSQTT ICRFENLQLS 250
    FKNACKLKSI LSKWLEEAEQ VGALYNEKVG VNERKRKRRT TISISAKEAL 300
    ERHFGEQSKP SSQEIMRMAE GLNLEKEVVR VWFCNRRQRE KRVKTSLHQN 350
    AFSSIIKEHH ECR 363
    Length:363
    Mass (Da):40,449
    Last modified:May 1, 1999 - v1
    Checksum:i424E43A40D28DDDB
    GO
    Isoform PIT-1 (identifier: Q9YGL7-3)

    Sequence is not available
    Length:
    Mass (Da):
    Isoform PIT-1* (identifier: Q9YGL7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         48-75: Missing.

    Show »
    Length:335
    Mass (Da):37,477
    Checksum:i3FDC854275E4B49B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei48 – 7528Missing in isoform PIT-1*. 1 PublicationVSP_002317Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ236856 mRNA. Translation: CAB37357.1.
    AJ236855 mRNA. Translation: CAB37356.1.
    UniGeneiGga.213.
    Gga.56300.
    Gga.56304.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ236856 mRNA. Translation: CAB37357.1 .
    AJ236855 mRNA. Translation: CAB37356.1 .
    UniGenei Gga.213.
    Gga.56300.
    Gga.56304.

    3D structure databases

    ProteinModelPortali Q9YGL7.
    SMRi Q9YGL7. Positions 200-344.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9YGL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG241031.
    HOGENOMi HOG000116302.
    HOVERGENi HBG053120.
    InParanoidi Q9YGL7.
    PhylomeDBi Q9YGL7.

    Miscellaneous databases

    PROi Q9YGL7.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR015586. Pit_1.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    PANTHERi PTHR11636:SF82. PTHR11636:SF82. 1 hit.
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complementary DNA cloning of pituitary specific transcription factor (Pit-1) from chicken."
      van As P., Buys N., Volckaert G., Decuypere E.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PIT-1* AND PIT-1BETA*).
      Strain: Ross.
      Tissue: Pituitary.

    Entry informationi

    Entry nameiPIT1_CHICK
    AccessioniPrimary (citable) accession number: Q9YGL7
    Secondary accession number(s): Q9YGL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3