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Q9YGL7

- PIT1_CHICK

UniProt

Q9YGL7 - PIT1_CHICK

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Protein
Pituitary-specific positive transcription factor 1
Gene
POU1F1, PIT1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi285 – 34460Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary-specific positive transcription factor 1
Short name:
PIT-1
Alternative name(s):
Growth hormone factor 1
Short name:
GHF-1
Gene namesi
Name:POU1F1
Synonyms:PIT1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Pituitary-specific positive transcription factor 1
PRO_0000100703Add
BLAST

Proteomic databases

PaxDbiQ9YGL7.

Expressioni

Tissue specificityi

Pituitary gland.

Structurei

3D structure databases

ProteinModelPortaliQ9YGL7.
SMRiQ9YGL7. Positions 200-344.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 26975POU-specific
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241031.
HOGENOMiHOG000116302.
HOVERGENiHBG053120.
InParanoidiQ9YGL7.
PhylomeDBiQ9YGL7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR015586. Pit_1.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF82. PTHR11636:SF82. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform PIT-1beta* (identifier: Q9YGL7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTCQAFASSD NFVPLNSDSS PSLPLIMHHS AGECLPVSNH ATNVVSTVPS    50
VLSLIQTPKC SHFHFAMMTS GNVSAGLHYS VPSCHYGNQA STYGVMAGIK 100
PATPEMLSAS LSQSRILQTC SMPHPNVVNG VSTLQSSLTP CLYKFPEHAL 150
SASSCALGHS FTPMHQTLLS DDPTASDFKQ EFRRKSKSVE EPVDMDSPEI 200
RELEKFANEF KLRRIKLGYT QTNVGEALAA VHGSEFSQTT ICRFENLQLS 250
FKNACKLKSI LSKWLEEAEQ VGALYNEKVG VNERKRKRRT TISISAKEAL 300
ERHFGEQSKP SSQEIMRMAE GLNLEKEVVR VWFCNRRQRE KRVKTSLHQN 350
AFSSIIKEHH ECR 363
Length:363
Mass (Da):40,449
Last modified:May 1, 1999 - v1
Checksum:i424E43A40D28DDDB
GO
Isoform PIT-1 (identifier: Q9YGL7-3)

Sequence is not available
Length:
Mass (Da):
Isoform PIT-1* (identifier: Q9YGL7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-75: Missing.

Show »
Length:335
Mass (Da):37,477
Checksum:i3FDC854275E4B49B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 7528Missing in isoform PIT-1*.
VSP_002317Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ236856 mRNA. Translation: CAB37357.1.
AJ236855 mRNA. Translation: CAB37356.1.
UniGeneiGga.213.
Gga.56300.
Gga.56304.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ236856 mRNA. Translation: CAB37357.1 .
AJ236855 mRNA. Translation: CAB37356.1 .
UniGenei Gga.213.
Gga.56300.
Gga.56304.

3D structure databases

ProteinModelPortali Q9YGL7.
SMRi Q9YGL7. Positions 200-344.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9YGL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG241031.
HOGENOMi HOG000116302.
HOVERGENi HBG053120.
InParanoidi Q9YGL7.
PhylomeDBi Q9YGL7.

Miscellaneous databases

PROi Q9YGL7.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR015586. Pit_1.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
PANTHERi PTHR11636:SF82. PTHR11636:SF82. 1 hit.
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complementary DNA cloning of pituitary specific transcription factor (Pit-1) from chicken."
    van As P., Buys N., Volckaert G., Decuypere E.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PIT-1* AND PIT-1BETA*).
    Strain: Ross.
    Tissue: Pituitary.

Entry informationi

Entry nameiPIT1_CHICK
AccessioniPrimary (citable) accession number: Q9YGL7
Secondary accession number(s): Q9YGL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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