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Q9YGL7 (PIT1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pituitary-specific positive transcription factor 1

Short name=PIT-1
Alternative name(s):
Growth hormone factor 1
Short name=GHF-1
Gene names
Name:POU1F1
Synonyms:PIT1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

Subcellular location

Nucleus By similarity.

Tissue specificity

Pituitary gland.

Sequence similarities

Belongs to the POU transcription factor family. Class-1 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform PIT-1beta* (identifier: Q9YGL7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PIT-1 (identifier: Q9YGL7-3)

The sequence of this isoform is not available.
Isoform PIT-1* (identifier: Q9YGL7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     48-75: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Pituitary-specific positive transcription factor 1
PRO_0000100703

Regions

Domain195 – 26975POU-specific
DNA binding285 – 34460Homeobox

Natural variations

Alternative sequence48 – 7528Missing in isoform PIT-1*.
VSP_002317

Sequences

Sequence LengthMass (Da)Tools
Isoform PIT-1beta* [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 424E43A40D28DDDB

FASTA36340,449
        10         20         30         40         50         60 
MTCQAFASSD NFVPLNSDSS PSLPLIMHHS AGECLPVSNH ATNVVSTVPS VLSLIQTPKC 

        70         80         90        100        110        120 
SHFHFAMMTS GNVSAGLHYS VPSCHYGNQA STYGVMAGIK PATPEMLSAS LSQSRILQTC 

       130        140        150        160        170        180 
SMPHPNVVNG VSTLQSSLTP CLYKFPEHAL SASSCALGHS FTPMHQTLLS DDPTASDFKQ 

       190        200        210        220        230        240 
EFRRKSKSVE EPVDMDSPEI RELEKFANEF KLRRIKLGYT QTNVGEALAA VHGSEFSQTT 

       250        260        270        280        290        300 
ICRFENLQLS FKNACKLKSI LSKWLEEAEQ VGALYNEKVG VNERKRKRRT TISISAKEAL 

       310        320        330        340        350        360 
ERHFGEQSKP SSQEIMRMAE GLNLEKEVVR VWFCNRRQRE KRVKTSLHQN AFSSIIKEHH 


ECR 

« Hide

Isoform PIT-1 (Sequence not available).
Isoform PIT-1* [UniParc].

Checksum: 3FDC854275E4B49B
Show »

FASTA33537,477

References

[1]"Complementary DNA cloning of pituitary specific transcription factor (Pit-1) from chicken."
van As P., Buys N., Volckaert G., Decuypere E.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PIT-1* AND PIT-1BETA*).
Strain: Ross.
Tissue: Pituitary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ236856 mRNA. Translation: CAB37357.1.
AJ236855 mRNA. Translation: CAB37356.1.
UniGeneGga.213.
Gga.56300.
Gga.56304.

3D structure databases

ProteinModelPortalQ9YGL7.
SMRQ9YGL7. Positions 200-344.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9YGL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG241031.
HOGENOMHOG000116302.
HOVERGENHBG053120.
InParanoidQ9YGL7.
PhylomeDBQ9YGL7.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR015586. Pit_1.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PANTHERPTHR11636:SF82. PTHR11636:SF82. 1 hit.
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9YGL7.

Entry information

Entry namePIT1_CHICK
AccessionPrimary (citable) accession number: Q9YGL7
Secondary accession number(s): Q9YGL8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families