Q9YGL6 (PALM_CHICK) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 68.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Paralemmin-1 Alternative name(s): Paralemmin | ||
| Gene names |
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| Organism | Gallus gallus (Chicken) [Reference proteome] | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 386 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner By similarity. |
| Subunit structure | Interacts with dopamine receptor DRD3 By similarity. |
| Subcellular location | Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection › filopodium membrane; Lipid-anchor By similarity. Cell projection › axon By similarity. Cell projection › dendrite By similarity. Cell projection › dendritic spine By similarity. Basolateral cell membrane By similarity; Lipid-anchor By similarity. Apicolateral cell membrane By similarity; Lipid-anchor By similarity Ref.1 Ref.2. |
| Tissue specificity | Expressed in the lens (at protein level). Highly expressed in forebrain and cerebellum with lower expression in adrenal gland and heart. Expression weak or undetectable in other tissues. Ref.1 Ref.2 |
| Post-translational modification | Phosphorylated By similarity. |
| Sequence similarities | Belongs to the paralemmin family. |
Ontologies
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9YGL6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9YGL6-2) The sequence of this isoform differs from the canonical sequence as follows: 138-202: Missing. | ||||||
| Isoform 3 (identifier: Q9YGL6-3) The sequence of this isoform differs from the canonical sequence as follows: 159-202: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 383 | 383 | Paralemmin-1 | PRO_0000058217 | |||||
| Propeptide | 384 – 386 | 3 | Removed in mature form Potential | PRO_0000396692 | |||||
Regions | |||||||||
| Coiled coil | 4 – 115 | 112 | Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 383 | 1 | Cysteine methyl ester Potential | ||||||
| Lipidation | 380 | 1 | S-palmitoyl cysteine Potential | ||||||
| Lipidation | 382 | 1 | S-palmitoyl cysteine Potential | ||||||
| Lipidation | 383 | 1 | S-farnesyl cysteine Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 138 – 202 | 65 | Missing in isoform 2. | VSP_003920 | |||||
| Alternative sequence | 159 – 202 | 44 | Missing in isoform 3. | VSP_003921 | |||||
Sequences
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References
| [1] | "Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation." Kutzleb C., Sanders G., Yamamoto R., Wang X., Lichte B., Petrasch-Parwez E., Kilimann M.W. J. Cell Biol. 143:795-813(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Brain. |
| [2] | "Paralemnin of the lens." Bagchi M., Katar M., Lo W.K., Maisel H. J. Cell. Biochem. 89:917-921(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Y14769 mRNA. Translation: CAB37358.1. Y14769 mRNA. Translation: CAB37359.1. Y14769 mRNA. Translation: CAB37360.1. |
| IPI | IPI00575722. IPI00819054. IPI00954735. |
| UniGene | Gga.5103. |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PaxDb | Q9YGL6. |
| PRIDE | Q9YGL6. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| eggNOG | NOG46471. |
| HOGENOM | HOG000043092. |
| HOVERGEN | HBG007431. |
| InParanoid | Q9YGL6. |
| OrthoDB | EOG4MGS7V. |
Family and domain databases | |
| InterPro | IPR004965. Paralemmin. [Graphical view] |
| Pfam | PF03285. Paralemmin. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PALM_CHICK | ||||||||
| Accession | Primary (citable) accession number: Q9YGL6 Secondary accession number(s): Q9YGL4, Q9YGL5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |