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Protein

Nuclear receptor subfamily 2 group E member 1

Gene

nr2e1

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be involved in the regulation of early eye development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi24 – 101Nuclear receptorPROSITE-ProRule annotationAdd BLAST78
Zinc fingeri27 – 47NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri63 – 89NR C4-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 2 group E member 1
Alternative name(s):
Nuclear receptor TLX
Protein tailless homolog
Short name:
Tll
Gene namesi
Name:nr2e1
Synonyms:tll, tlx
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535951 – 396Nuclear receptor subfamily 2 group E member 1Add BLAST396

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi8090.ENSORLP00000016838.

Structurei

3D structure databases

ProteinModelPortaliQ9YGL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 365Ligand-bindingBy similarityAdd BLAST168

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi354 – 358Poly-Leu5

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri27 – 47NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri63 – 89NR C4-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiQ9YGL3.
KOiK08545.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YGL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPTGSTSG CLDILNVKSS RILDIPCKVC GDRSSGKHYG VYACDGCSGF
60 70 80 90 100
FKRSIRRNRI YLCKSGSQGG CPVDKTHRNQ CRACRLKKCL EVNMNKDAVQ
110 120 130 140 150
HERGPRTSTI RKQVALYFRG HKEVNGSSTH FPGSSLPGPP FFTTVTQLEP
160 170 180 190 200
HNLEMSSVAT TPERQAIVGL AQPTPKYPHE VSGTPMYLYE VATESVCESA
210 220 230 240 250
ARLLFMSIKW AKSVPAFSTL PLSDQLILLE DAWRELFVLG IAQWAIPVDS
260 270 280 290 300
TTLLAVSGLN SENMEAQRMN KIMAEIQALQ EVVTRFRQMR LDATEFACLK
310 320 330 340 350
CIVTFKAVPT QGSAELRAFR NASAIAALQD EAQLTLNSYI HTRYPTQPCR
360 370 380 390
FGKLLLLLPA LRSVSPSTIE EVFFKKNIGN VPITRLLSDM YKSSDI
Length:396
Mass (Da):43,907
Last modified:May 1, 1999 - v1
Checksum:iF0138410AFE98553
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131390 mRNA. Translation: CAB38085.1.
RefSeqiNP_001098343.1. NM_001104873.1.
UniGeneiOla.69.

Genome annotation databases

GeneIDi100049530.
KEGGiola:100049530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131390 mRNA. Translation: CAB38085.1.
RefSeqiNP_001098343.1. NM_001104873.1.
UniGeneiOla.69.

3D structure databases

ProteinModelPortaliQ9YGL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000016838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100049530.
KEGGiola:100049530.

Organism-specific databases

CTDi7101.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiQ9YGL3.
KOiK08545.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNR2E1_ORYLA
AccessioniPrimary (citable) accession number: Q9YGL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.