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Protein

Interleukin-1 beta

Gene

il1b

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

GO - Molecular functioni

GO - Biological processi

  • cortisol secretion Source: AgBase
  • fever generation Source: UniProtKB-KW
  • immune response Source: InterPro
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of gene expression Source: AgBase
  • positive regulation of leukocyte chemotaxis Source: AgBase
  • positive regulation of phagocytosis Source: AgBase
  • positive regulation of protein phosphorylation Source: AgBase
  • regulation of calcium ion transport Source: AgBase
  • T cell proliferation Source: AgBase

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Gene namesi
Name:il1b
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000015324? – 260Interleukin-1 beta
PropeptideiPRO_00000153231 – ?

Expressioni

Tissue specificityi

All three isoforms are expressed in gill, kidney, liver and spleen. Isoform 1 is also expressed in blood. None of the isoforms are expressed in brain.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OOXmodel-A95-260[»]
ProteinModelPortaliQ9YGD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

HOVERGENiHBG106914.

Family and domain databases

InterProiView protein in InterPro
IPR000975. IL-1_fam.
IPR008996. IL1/FGF.
PfamiView protein in Pfam
PF00340. IL1. 1 hit.
PRINTSiPR00264. INTERLEUKIN1.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YGD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFESNYSLI KNTSESAAWS SKLPQGLDLE VSHHPITMRH IANLIIAMER
60 70 80 90 100
LKGGEGVTMG TEFKDKDLLN FLLESAVEEH IVLELESAPP ASRRAAGFSS
110 120 130 140 150
TSQYECSVTD SENKCWVLMN EAMELHAMML QGGSSYHKVH LNLSSYVTPV
160 170 180 190 200
PIETEARPVA LGIKGSNLYL SCSKSGGRPT LHLEEVADKD QLKSISQQSD
210 220 230 240 250
MVRFLFYRRN TGVDISTLES ASFRNWFIST DMQQDYTKPV DMCQKAAPNR
260
LTTFTIQRHN
Length:260
Mass (Da):29,127
Last modified:May 1, 1999 - v1
Checksum:i0DC77991EA53E97F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ004821 Genomic DNA. Translation: CAA06157.1.
AJ223954 mRNA. Translation: CAA11684.1.
AJ278242 Genomic DNA. Translation: CAB93352.1.
RefSeqiNP_001117819.1. NM_001124347.2.
UniGeneiOmy.11696.

Genome annotation databases

GeneIDi100136024.

Similar proteinsi

Entry informationi

Entry nameiIL1B_ONCMY
AccessioniPrimary (citable) accession number: Q9YGD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families