Q9YGB5 (TRPC_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	TK0252

Organism

Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1))

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_A
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_A
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Indole-3-glycerol phosphate synthase HAMAP MF_00134_A		PRO_0000154300
Experimental info
	Sequence conflict	215	1	P → R in BAA82545. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9YGB5 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: A91D797C71B162D4	FASTA	227	25,374
	10 20 30 40 50 60 MVFGLSRAIR KAEKNAIIAE LKVYSPKYGD LLKGRNPFEI LRAYERAGAV GISYITDPKY 70 80 90 100 110 120 FRGSFEFLRK LCRETELPVL RKDFIASKEE VERTAEAGAS AVLLITRLLK EELPEFVDFA 130 140 150 160 170 180 KEHGLDTLVE VHSEEELAIA LQTDSTMIGI NNRDIGKLEL DDGNVSLTEK LAPLIPKRYV 190 200 210 220 KVSESGIAGT EDLKRALRHA DAALIGTALM KTPDPEEFLR KLVEVEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA." Tang X., Ezaki S., Fujiwara S., Takagi M., Atomi H., Imanaka T. Mol. Gen. Genet. 262:815-821(1999) [PubMed: 10628865] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.
[2]	"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB030011 Genomic DNA. Translation: BAA82545.1. AP006878 Genomic DNA. Translation: BAD84441.1.
PIR	T43922.
RefSeq	YP_182665.1. NC_006624.1.
3D structure databases
ProteinModelPortal	Q9YGB5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000007507; EBPYRP00000007288; EBPYRG00000007506.
GeneID	3234097.
GenomeReviews	Gene locus TK0252 in contig AP006878_GR.
KEGG	tko:TK0252.
NMPDR	fig|69014.3.peg.525.
Phylogenomic databases
eggNOG	arNOG04622.
GeneTree	EBGT00050000022896.
HOGENOM	HBG540956.
OMA	FFPEQVK.
PhylomeDB	Q9YGB5.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-3581. TKOD69014:TK0252-MONOMER.
Family and domain databases
HAMAP	MF_00134_A. IGPS_A. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_PYRKO

Accession

Primary (citable) accession number: Q9YGB5
Secondary accession number(s): Q5JFU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	March 29, 2005
Last modified:	December 14, 2011
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program