Reviewed, UniProtKB/Swiss-Prot Q9YGB3 (TRPE_PYRKO)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	TK0254

Organism

Pyrococcus kodakaraensis (Thermococcus kodakaraensis) [Complete proteome] [HAMAP]

Taxonomic identifier

311400 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Anthranilate synthase component 1		PRO_0000154131

Sequences

	Sequence		Length	Mass (Da)
	Q9YGB3-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: E2C539B23365D599	FASTA	433	48,541
	10 20 30 40 50 60 MPLKKLKPVD PLKLYSALRD FGMPFMLRSA EKDSRKARFT YISAEPEFVV EVGEGTEIDG 70 80 90 100 110 120 ERVSDERNPL RALKGLMGER VEGRRFMGGF VGYVSYDSVH SIIGGKIEEP SVFGYYPWTF 130 140 150 160 170 180 IYDHSTGALS FFYLREAPFD PEALVERARR EESRLEDGGS EVISTDAGME EFVEIVRAGK 190 200 210 220 230 240 EYIYSGDVFQ VVLSREYRVR TDLDALEIYK RLVELNPSPY TFILEFEKTV VGASPETMGS 250 260 270 280 290 300 VEGRTFKINP IAGTAPRGRT GEEDRELEKA LLSDEKERAE HVMLVDLARN DVRRVSKPGS 310 320 330 340 350 360 VRLTRFFDVL KYSHVQHIES EVVGELDEGK NAFDAMEAAF PAGTLTGAPK IRAMEIIDEL 370 380 390 400 410 420 ERSRRKVYGG AVGYFSLTGD ADMAIAIRMA EIEGRKASVR AGAGIVADSV PEKEFFETEN 430 KMRAVLKALG VRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA." Tang X., Ezaki S., Fujiwara S., Takagi M., Atomi H., Imanaka T. Mol. Gen. Genet. 262:815-821(1999) [PubMed: 10628865] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: KOD1.
[2]	"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB030011 Genomic DNA. Translation: BAA82547.1. AP006878 Genomic DNA. Translation: BAD84443.1.
PIR	T43924.
RefSeq	YP_182667.1.
3D structure databases
SMR	Q9YGB3. Positions 1-432.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9YGB3.
Genome annotation databases
GeneID	3235373.
GenomeReviews	Gene locus TK0254 in contig AP006878_GR.
KEGG	tko:TK0254.
NMPDR	fig|69014.3.peg.1.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04620.
HOGENOM	HBG507440.
OMA	IRMAEID.
PhylomeDB	Q9YGB3.
Enzyme and pathway databases
BioCyc	TKOD69014:TK0254-MONOMER.
BRENDA	4.1.3.27. 192130.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR010116. Anthranilate_synth_I_arc. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
TIGRFAMs	TIGR01820. TrpE-arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_PYRKO

Accession

Primary (citable) accession number: Q9YGB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)