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Q9YGB1

- TRPF_THEKO

UniProt

Q9YGB1 - TRPF_THEKO

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Protein
N-(5'-phosphoribosyl)anthranilate isomerase
Gene
trpF, TK0256
Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciTKOD69014:GH72-258-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:TK0256
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
PRO_0000154413Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi69014.TK0256.

Structurei

3D structure databases

ProteinModelPortaliQ9YGB1.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.

Phylogenomic databases

eggNOGiCOG0135.
HOGENOMiHOG000161598.
KOiK01817.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YGB1-1 [UniParc]FASTAAdd to Basket

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MVEFVKICGV KTMDELRLVE RYADATGVVV NSRSKRKVPL KTAAELIEMA    50
EIPIYLVSTM KTFPEWANAV EKTGAEYIQV HSDMHPKAVN RLKDEYGVSV 100
MKAFMVPRES DDPAEDAERL LELIGQYEVD KILLDTGVGS GRRHDYRVSA 150
IIAKEYPIVL AGGLTPENVG EAIRWVKPAG VDVSSGVERN GVKDRVLIEA 200
FMAVVRNG 208
Length:208
Mass (Da):23,049
Last modified:November 1, 1999 - v1
Checksum:i54D5DDB85F9312A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB030011 Genomic DNA. Translation: BAA82549.1.
AP006878 Genomic DNA. Translation: BAD84445.1.
PIRiT43926.
RefSeqiYP_182669.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84445; BAD84445; TK0256.
GeneIDi3235375.
KEGGitko:TK0256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB030011 Genomic DNA. Translation: BAA82549.1 .
AP006878 Genomic DNA. Translation: BAD84445.1 .
PIRi T43926.
RefSeqi YP_182669.1. NC_006624.1.

3D structure databases

ProteinModelPortali Q9YGB1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 69014.TK0256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD84445 ; BAD84445 ; TK0256 .
GeneIDi 3235375.
KEGGi tko:TK0256.

Phylogenomic databases

eggNOGi COG0135.
HOGENOMi HOG000161598.
KOi K01817.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
BioCyci TKOD69014:GH72-258-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA."
    Tang X., Ezaki S., Fujiwara S., Takagi M., Atomi H., Imanaka T.
    Mol. Gen. Genet. 262:815-821(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.
  2. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiTRPF_THEKO
AccessioniPrimary (citable) accession number: Q9YGB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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