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Q9YGB1

- TRPF_THEKO

UniProt

Q9YGB1 - TRPF_THEKO

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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciTKOD69014:GH72-258-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:TK0256
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154413Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi69014.TK0256.

Structurei

3D structure databases

ProteinModelPortaliQ9YGB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0135.
HOGENOMiHOG000161598.
InParanoidiQ9YGB1.
KOiK01817.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YGB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVEFVKICGV KTMDELRLVE RYADATGVVV NSRSKRKVPL KTAAELIEMA
60 70 80 90 100
EIPIYLVSTM KTFPEWANAV EKTGAEYIQV HSDMHPKAVN RLKDEYGVSV
110 120 130 140 150
MKAFMVPRES DDPAEDAERL LELIGQYEVD KILLDTGVGS GRRHDYRVSA
160 170 180 190 200
IIAKEYPIVL AGGLTPENVG EAIRWVKPAG VDVSSGVERN GVKDRVLIEA

FMAVVRNG
Length:208
Mass (Da):23,049
Last modified:November 1, 1999 - v1
Checksum:i54D5DDB85F9312A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030011 Genomic DNA. Translation: BAA82549.1.
AP006878 Genomic DNA. Translation: BAD84445.1.
PIRiT43926.
RefSeqiYP_182669.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84445; BAD84445; TK0256.
GeneIDi3235375.
KEGGitko:TK0256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030011 Genomic DNA. Translation: BAA82549.1 .
AP006878 Genomic DNA. Translation: BAD84445.1 .
PIRi T43926.
RefSeqi YP_182669.1. NC_006624.1.

3D structure databases

ProteinModelPortali Q9YGB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 69014.TK0256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD84445 ; BAD84445 ; TK0256 .
GeneIDi 3235375.
KEGGi tko:TK0256.

Phylogenomic databases

eggNOGi COG0135.
HOGENOMi HOG000161598.
InParanoidi Q9YGB1.
KOi K01817.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
BioCyci TKOD69014:GH72-258-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA."
    Tang X., Ezaki S., Fujiwara S., Takagi M., Atomi H., Imanaka T.
    Mol. Gen. Genet. 262:815-821(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.
  2. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiTRPF_THEKO
AccessioniPrimary (citable) accession number: Q9YGB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3