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Q9YG90

- ALF1_AERPE

UniProt

Q9YG90 - ALF1_AERPE

Protein

Probable fructose-bisphosphate aldolase class 1

Gene

fba

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 3 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Enzyme regulationi

    Activated by citrate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei184 – 1841Schiff-base intermediate with dihydroxyacetone-PBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciAPER272557:GJD6-8-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
    Alternative name(s):
    Probable fructose-bisphosphate aldolase class I
    Short name:
    FBP aldolase
    Gene namesi
    Name:fba
    Ordered Locus Names:APE_0011.1
    OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
    Taxonomic identifieri272557 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
    ProteomesiUP000002518: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Probable fructose-bisphosphate aldolase class 1PRO_0000138947Add
    BLAST

    Interactioni

    Subunit structurei

    Homooligomer.By similarity

    Protein-protein interaction databases

    STRINGi272557.APE_0011.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9YG90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DeoC/FbaB aldolase family.Curated

    Phylogenomic databases

    eggNOGiCOG1830.
    HOGENOMiHOG000224790.
    KOiK11645.
    OMAiSRNMVII.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view]
    PfamiPF01791. DeoC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9YG90-1 [UniParc]FASTAAdd to Basket

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    MISSQDVGKR VRLSRILPDG RSVIFAFDHG IEHGPGEIPE ERLDPRLLIR    50
    EVVEAGVDAI MTTPGIARLT WDIWANRVAM IIKVSGKTSI RPQDDQFLQS 100
    AISSVDEVVA LGGDGVAATV YWGSQFEDKM LERWTRIRLR AEKLGLPALQ 150
    LAYPRGPHIK NRYAVDIVAY GARAAMETGA DLIKTYYTGS TESFRRVVSA 200
    AGGVPVLMSG GARTPSPQEF LHKVYSVMEA GGGGVVVGRN IFQAGDIRAM 250
    VKAIRAIVHE GFDPEKASKL LG 272
    Length:272
    Mass (Da):29,583
    Last modified:June 6, 2002 - v3
    Checksum:iD992DAFA81A6ADAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA78920.2.
    PIRiF72752.
    RefSeqiNP_146901.2. NC_000854.2.

    Genome annotation databases

    EnsemblBacteriaiBAA78920; BAA78920; APE_0011.1.
    GeneIDi1445583.
    KEGGiape:APE_0011.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA78920.2 .
    PIRi F72752.
    RefSeqi NP_146901.2. NC_000854.2.

    3D structure databases

    ProteinModelPortali Q9YG90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272557.APE_0011.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA78920 ; BAA78920 ; APE_0011.1 .
    GeneIDi 1445583.
    KEGGi ape:APE_0011.1.

    Phylogenomic databases

    eggNOGi COG1830.
    HOGENOMi HOG000224790.
    KOi K11645.
    OMAi SRNMVII.

    Enzyme and pathway databases

    BioCyci APER272557:GJD6-8-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view ]
    Pfami PF01791. DeoC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038992. Aldolase_Ia. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

    Entry informationi

    Entry nameiALF1_AERPE
    AccessioniPrimary (citable) accession number: Q9YG90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3