Reviewed, UniProtKB/Swiss-Prot Q9YG90 (ALF1_AERPE)

Names and origin

Protein names

Recommended name:
    Probable fructose-bisphosphate aldolase class 1
    EC=4.1.2.13
Alternative name(s):
    Probable fructose-bisphosphate aldolase class I
      Short name=FBP aldolase

Gene names

Name:	fba
Ordered Locus Names:	APE_0011.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Enzyme regulation	Activated by citrate By similarity.
Subunit structure	Homooligomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the deoC/fbaB aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Probable fructose-bisphosphate aldolase class 1		PRO_0000138947
Sites
	Active site	184	1	Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9YG90-1 [UniParc]. Last modified June 6, 2002. Version 3. Checksum: D992DAFA81A6ADAF	FASTA	272	29,583
	10 20 30 40 50 60 MISSQDVGKR VRLSRILPDG RSVIFAFDHG IEHGPGEIPE ERLDPRLLIR EVVEAGVDAI 70 80 90 100 110 120 MTTPGIARLT WDIWANRVAM IIKVSGKTSI RPQDDQFLQS AISSVDEVVA LGGDGVAATV 130 140 150 160 170 180 YWGSQFEDKM LERWTRIRLR AEKLGLPALQ LAYPRGPHIK NRYAVDIVAY GARAAMETGA 190 200 210 220 230 240 DLIKTYYTGS TESFRRVVSA AGGVPVLMSG GARTPSPQEF LHKVYSVMEA GGGGVVVGRN 250 260 270 IFQAGDIRAM VKAIRAIVHE GFDPEKASKL LG

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA78920.2.
PIR	F72752.
RefSeq	NP_146901.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1445583.
GenomeReviews	Gene locus APE_0011.1 in contig BA000002_GR.
KEGG	ape:APE_0011.1.
NMPDR	fig|272557.1.peg.8.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YG90.
OMA	Q9YG90. VRHGHRG.
Enzyme and pathway databases
BRENDA	4.1.2.13. 256344.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF1_AERPE

Accession

Primary (citable) accession number: Q9YG90

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 6, 2002
Last modified:	June 16, 2009
This is version 49 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)