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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
Ordered Locus Names:APE_0069.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001536341 – 159Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST159

Proteomic databases

PRIDEiQ9YG32

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0069.1

Structurei

3D structure databases

ProteinModelPortaliQ9YG32
SMRiQ9YG32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048 Archaea
COG0717 LUCA
HOGENOMiHOG000228599
KOiK01520
OrthoDBiPOG093Z0E8X

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00635 dUTPase_arch, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR023537 dUTPase_archaeal
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YG32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLSGRDLVL LGVVKGHSNG AIQPAGVDLS VGEIESLADA GFLGEEDKIM
60 70 80 90 100
PKGDRIQCEY GVCELEPGAY RLRFNEVVSI PPGHVGFCFP RSSLLRMGCY
110 120 130 140 150
LGCAVWDPGY TGRGQAMLLV ANPHGLRLEM GSRIAQLVVA RVEGPLTSLY

KGDYQGEGL
Length:159
Mass (Da):17,056
Last modified:June 26, 2007 - v2
Checksum:i32E03EA0EBA7AECB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA78978.2
PIRiH72759

Genome annotation databases

EnsemblBacteriaiBAA78978; BAA78978; APE_0069.1
KEGGiape:APE_0069.1

Similar proteinsi

Entry informationi

Entry nameiDUT_AERPE
AccessioniPrimary (citable) accession number: Q9YG32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 26, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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