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Q9YG32 (DUT_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:dut
Ordered Locus Names:APE_0069.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP-Rule MF_00635

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP-Rule MF_00635

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP-Rule MF_00635

Sequence similarities

Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159Probable deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP-Rule MF_00635
PRO_0000153634

Sequences

Sequence LengthMass (Da)Tools
Q9YG32 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: 32E03EA0EBA7AECB

FASTA15917,056
        10         20         30         40         50         60 
MFLSGRDLVL LGVVKGHSNG AIQPAGVDLS VGEIESLADA GFLGEEDKIM PKGDRIQCEY 

        70         80         90        100        110        120 
GVCELEPGAY RLRFNEVVSI PPGHVGFCFP RSSLLRMGCY LGCAVWDPGY TGRGQAMLLV 

       130        140        150 
ANPHGLRLEM GSRIAQLVVA RVEGPLTSLY KGDYQGEGL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA78978.2.
PIRH72759.
RefSeqNP_146937.2. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YG32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_0069.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA78978; BAA78978; APE_0069.1.
GeneID1445620.
KEGGape:APE_0069.1.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0717.
HOGENOMHOG000228599.
KOK01520.

Enzyme and pathway databases

BioCycAPER272557:GJD6-41-MONOMER.
UniPathwayUPA00610; UER00666.

Family and domain databases

Gene3D2.70.40.10. 1 hit.
HAMAPMF_00635. dUTPase_arch.
InterProIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMSSF51283. SSF51283. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_AERPE
AccessionPrimary (citable) accession number: Q9YG32
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 26, 2007
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways