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Q9YG32

- DUT_AERPE

UniProt

Q9YG32 - DUT_AERPE

Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Enzyme and pathway databases

    BioCyciAPER272557:GJD6-41-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:APE_0069.1
    OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
    Taxonomic identifieri272557 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
    ProteomesiUP000002518: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 159159Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000153634Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272557.APE_0069.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9YG32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0717.
    HOGENOMiHOG000228599.
    KOiK01520.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00635. dUTPase_arch.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR023537. dUTPase_archaeal.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9YG32-1 [UniParc]FASTAAdd to Basket

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    MFLSGRDLVL LGVVKGHSNG AIQPAGVDLS VGEIESLADA GFLGEEDKIM    50
    PKGDRIQCEY GVCELEPGAY RLRFNEVVSI PPGHVGFCFP RSSLLRMGCY 100
    LGCAVWDPGY TGRGQAMLLV ANPHGLRLEM GSRIAQLVVA RVEGPLTSLY 150
    KGDYQGEGL 159
    Length:159
    Mass (Da):17,056
    Last modified:June 26, 2007 - v2
    Checksum:i32E03EA0EBA7AECB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA78978.2.
    PIRiH72759.
    RefSeqiNP_146937.2. NC_000854.2.
    WP_010865464.1. NC_000854.2.

    Genome annotation databases

    EnsemblBacteriaiBAA78978; BAA78978; APE_0069.1.
    GeneIDi1445620.
    KEGGiape:APE_0069.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA78978.2 .
    PIRi H72759.
    RefSeqi NP_146937.2. NC_000854.2.
    WP_010865464.1. NC_000854.2.

    3D structure databases

    ProteinModelPortali Q9YG32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272557.APE_0069.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA78978 ; BAA78978 ; APE_0069.1 .
    GeneIDi 1445620.
    KEGGi ape:APE_0069.1.

    Phylogenomic databases

    eggNOGi COG0717.
    HOGENOMi HOG000228599.
    KOi K01520.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci APER272557:GJD6-41-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00635. dUTPase_arch.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR023537. dUTPase_archaeal.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

    Entry informationi

    Entry nameiDUT_AERPE
    AccessioniPrimary (citable) accession number: Q9YG32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3