Reviewed, UniProtKB/Swiss-Prot Q9YG32 (DUT_AERPE)

Names and origin

Protein names

Recommended name:
    Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
      Short name=dUTPase
    EC=3.6.1.23
Alternative name(s):
    dUTP pyrophosphatase

Gene names

Name:	dut
Ordered Locus Names:	APE_0069.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate. HAMAP MF_00635
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00635
Sequence similarities	Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 159	159	Probable deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00635		PRO_0000153634

Sequences

	Sequence		Length	Mass (Da)
	Q9YG32-1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 32E03EA0EBA7AECB	FASTA	159	17,056
	10 20 30 40 50 60 MFLSGRDLVL LGVVKGHSNG AIQPAGVDLS VGEIESLADA GFLGEEDKIM PKGDRIQCEY 70 80 90 100 110 120 GVCELEPGAY RLRFNEVVSI PPGHVGFCFP RSSLLRMGCY LGCAVWDPGY TGRGQAMLLV 130 140 150 ANPHGLRLEM GSRIAQLVVA RVEGPLTSLY KGDYQGEGL

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA78978.2.
PIR	H72759.
RefSeq	NP_146937.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1445620.
GenomeReviews	Gene locus APE_0069.1 in contig BA000002_GR.
KEGG	ape:APE_0069.1.
NMPDR	fig|272557.1.peg.44.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YG32.
Enzyme and pathway databases
BRENDA	3.6.1.23. 256344.
Family and domain databases
HAMAP	MF_00635. [Tree]
InterPro	IPR008180. DeoxyUTP_pyroPase_dom. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProDom	PD004900. dCTP_deaminase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

DUT_AERPE

Accession

Primary (citable) accession number: Q9YG32

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	June 26, 2007
Last modified:	September 22, 2009
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)