Q9YG32 (DUT_AERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

Name:	dut
Ordered Locus Names:	APE_0069.1

Organism

Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]

Taxonomic identifier

272557 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum › Aeropyrum pernix

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP-Rule MF_00635
Catalytic activity	dUTP + H2O = dUMP + diphosphate. HAMAP-Rule MF_00635
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP-Rule MF_00635
Sequence similarities	Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 159	159	Probable deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP-Rule MF_00635		PRO_0000153634

Sequences

	Sequence		Length	Mass (Da)
	Q9YG32 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 32E03EA0EBA7AECB	FASTA	159	17,056
	10 20 30 40 50 60 MFLSGRDLVL LGVVKGHSNG AIQPAGVDLS VGEIESLADA GFLGEEDKIM PKGDRIQCEY 70 80 90 100 110 120 GVCELEPGAY RLRFNEVVSI PPGHVGFCFP RSSLLRMGCY LGCAVWDPGY TGRGQAMLLV 130 140 150 ANPHGLRLEM GSRIAQLVVA RVEGPLTSLY KGDYQGEGL

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA78978.2.
PIR	H72759.
RefSeq	NP_146937.2. NC_000854.2.
3D structure databases
ProteinModelPortal	Q9YG32.
ModBase	Search...
Protein-protein interaction databases
STRING	272557.APE_0069.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA78978; BAA78978; APE_0069.1.
GeneID	1445620.
KEGG	ape:APE_0069.1.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0717.
HOGENOM	HOG000228599.
KO	K01520.
ProtClustDB	PRK02253.
Enzyme and pathway databases
BioCyc	APER272557:GJD6-41-MONOMER.
UniPathway	UPA00610; UER00666.
Family and domain databases
HAMAP	MF_00635. dUTPase_arch.
InterPro	IPR008180. dUTP_pyroPase. IPR023537. dUTP_pyroPase_arch. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_AERPE

Accession

Primary (citable) accession number: Q9YG32

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program