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Q9YG32

- DUT_AERPE

UniProt

Q9YG32 - DUT_AERPE

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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciAPER272557:GJD6-41-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
Ordered Locus Names:APE_0069.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000153634Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0069.1.

Structurei

3D structure databases

ProteinModelPortaliQ9YG32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228599.
KOiK01520.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00635. dUTPase_arch.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YG32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLSGRDLVL LGVVKGHSNG AIQPAGVDLS VGEIESLADA GFLGEEDKIM
60 70 80 90 100
PKGDRIQCEY GVCELEPGAY RLRFNEVVSI PPGHVGFCFP RSSLLRMGCY
110 120 130 140 150
LGCAVWDPGY TGRGQAMLLV ANPHGLRLEM GSRIAQLVVA RVEGPLTSLY

KGDYQGEGL
Length:159
Mass (Da):17,056
Last modified:June 26, 2007 - v2
Checksum:i32E03EA0EBA7AECB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA78978.2.
PIRiH72759.
RefSeqiNP_146937.2. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA78978; BAA78978; APE_0069.1.
GeneIDi1445620.
KEGGiape:APE_0069.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA78978.2 .
PIRi H72759.
RefSeqi NP_146937.2. NC_000854.2.

3D structure databases

ProteinModelPortali Q9YG32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_0069.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA78978 ; BAA78978 ; APE_0069.1 .
GeneIDi 1445620.
KEGGi ape:APE_0069.1.

Phylogenomic databases

eggNOGi COG0717.
HOGENOMi HOG000228599.
KOi K01520.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci APER272557:GJD6-41-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00635. dUTPase_arch.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiDUT_AERPE
AccessioniPrimary (citable) accession number: Q9YG32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 26, 2007
Last modified: October 29, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3