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Q9YG32

- DUT_AERPE

UniProt

Q9YG32 - DUT_AERPE

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Protein
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
dut, APE_0069.1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciAPER272557:GJD6-41-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:APE_0069.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation
PRO_0000153634Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0069.1.

Structurei

3D structure databases

ProteinModelPortaliQ9YG32.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228599.
KOiK01520.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00635. dUTPase_arch.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YG32-1 [UniParc]FASTAAdd to Basket

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MFLSGRDLVL LGVVKGHSNG AIQPAGVDLS VGEIESLADA GFLGEEDKIM    50
PKGDRIQCEY GVCELEPGAY RLRFNEVVSI PPGHVGFCFP RSSLLRMGCY 100
LGCAVWDPGY TGRGQAMLLV ANPHGLRLEM GSRIAQLVVA RVEGPLTSLY 150
KGDYQGEGL 159
Length:159
Mass (Da):17,056
Last modified:June 26, 2007 - v2
Checksum:i32E03EA0EBA7AECB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA78978.2.
PIRiH72759.
RefSeqiNP_146937.2. NC_000854.2.
WP_010865464.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA78978; BAA78978; APE_0069.1.
GeneIDi1445620.
KEGGiape:APE_0069.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA78978.2 .
PIRi H72759.
RefSeqi NP_146937.2. NC_000854.2.
WP_010865464.1. NC_000854.2.

3D structure databases

ProteinModelPortali Q9YG32.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272557.APE_0069.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA78978 ; BAA78978 ; APE_0069.1 .
GeneIDi 1445620.
KEGGi ape:APE_0069.1.

Phylogenomic databases

eggNOGi COG0717.
HOGENOMi HOG000228599.
KOi K01520.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci APER272557:GJD6-41-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00635. dUTPase_arch.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiDUT_AERPE
AccessioniPrimary (citable) accession number: Q9YG32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 26, 2007
Last modified: September 3, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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