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Protein

ORC1-type DNA replication protein 2

Gene

orc2

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of DNA replication (By similarity). Binds DNA.UniRule annotation1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131ATPUniRule annotation1 Publication
Binding sitei225 – 2251ATPUniRule annotation1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi60 – 656ATPUniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-105-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ORC1-type DNA replication protein 2UniRule annotation
Alternative name(s):
ORC2
Gene namesi
Name:orc2
Ordered Locus Names:APE_0152.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410ORC1-type DNA replication protein 2PRO_0000421876Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0152.1.

Structurei

Secondary structure

1
410
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 134Combined sources
Beta strandi23 – 253Combined sources
Helixi27 – 4115Combined sources
Beta strandi49 – 546Combined sources
Beta strandi60 – 623Combined sources
Helixi63 – 8018Combined sources
Beta strandi85 – 917Combined sources
Helixi92 – 943Combined sources
Helixi98 – 10912Combined sources
Helixi120 – 13415Combined sources
Beta strandi137 – 1448Combined sources
Helixi146 – 1494Combined sources
Helixi156 – 1638Combined sources
Helixi165 – 1684Combined sources
Beta strandi177 – 18610Combined sources
Helixi188 – 1969Combined sources
Helixi198 – 2014Combined sources
Beta strandi205 – 2095Combined sources
Helixi215 – 22915Combined sources
Helixi237 – 24711Combined sources
Helixi249 – 2513Combined sources
Helixi257 – 27317Combined sources
Helixi281 – 29010Combined sources
Beta strandi300 – 3045Combined sources
Helixi306 – 32015Combined sources
Beta strandi324 – 3263Combined sources
Helixi328 – 34316Combined sources
Helixi350 – 36213Combined sources
Beta strandi365 – 3695Combined sources
Beta strandi381 – 3844Combined sources
Helixi390 – 40516Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W5SX-ray2.40A/B2-410[»]
1W5TX-ray2.40A/B/C2-410[»]
ProteinModelPortaliQ9YFU8.
SMRiQ9YFU8. Positions 5-407.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YFU8.

Family & Domainsi

Domaini

Contains an N-terminal AAA+ ATPase domain and a C-terminal winged-helix (WH) domain.1 Publication

Sequence similaritiesi

Belongs to the CDC6/cdc18 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00467. Archaea.
COG1474. LUCA.
HOGENOMiHOG000153950.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01407. ORC1_type_DNA_replic_protein. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C.
IPR014277. Orc1/Cdc6_arc.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13401. AAA_22. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02928. TIGR02928. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YFU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRHGLFKDR RVFDENYIPP ELRVRRGEAE ALARIYLNRL LSGAGLSDVN
60 70 80 90 100
MIYGSIGRVG IGKTTLAKFT VKRVSEAAAK EGLTVKQAYV NAFNAPNLYT
110 120 130 140 150
ILSLIVRQTG YPIQVRGAPA LDILKALVDN LYVENHYLLV ILDEFQSMLS
160 170 180 190 200
SPRIAAEDLY TLLRVHEEIP SRDGVNRIGF LLVASDVRAL SYMREKIPQV
210 220 230 240 250
ESQIGFKLHL PAYKSRELYT ILEQRAELGL RDTVWEPRHL ELISDVYGED
260 270 280 290 300
KGGDGSARRA IVALKMACEM AEAMGRDSLS EDLVRKAVSE NEAASIQTHE
310 320 330 340 350
LEALSIHELI ILRLIAEATL GGMEWINAGL LRQRYEDASL TMYNVKPRGY
360 370 380 390 400
TQYHIYLKHL TSLGLVDAKP SGRGMRGRTT LFRLAPHLPA DRLIEVVDNI
410
IQAKMASGYE
Length:410
Mass (Da):46,005
Last modified:November 14, 2006 - v2
Checksum:i28D950272EB88043
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79063.2.
PIRiE72770.

Genome annotation databases

EnsemblBacteriaiBAA79063; BAA79063; APE_0152.1.
KEGGiape:APE_0152.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79063.2.
PIRiE72770.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W5SX-ray2.40A/B2-410[»]
1W5TX-ray2.40A/B/C2-410[»]
ProteinModelPortaliQ9YFU8.
SMRiQ9YFU8. Positions 5-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_0152.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA79063; BAA79063; APE_0152.1.
KEGGiape:APE_0152.1.

Phylogenomic databases

eggNOGiarCOG00467. Archaea.
COG1474. LUCA.
HOGENOMiHOG000153950.

Enzyme and pathway databases

BioCyciAPER272557:GJD6-105-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9YFU8.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01407. ORC1_type_DNA_replic_protein. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C.
IPR014277. Orc1/Cdc6_arc.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13401. AAA_22. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02928. TIGR02928. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDC62_AERPE
AccessioniPrimary (citable) accession number: Q9YFU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.