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Q9YFS7 (PGK_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:APE_0173.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000146049

Regions

Nucleotide binding362 – 3654ATP By similarity
Region28 – 303Substrate binding By similarity
Region67 – 704Substrate binding By similarity

Sites

Binding site441Substrate By similarity
Binding site1241Substrate By similarity
Binding site1641Substrate By similarity
Binding site3361ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9YFS7 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: 710CBF57112A82CF

FASTA41544,902
        10         20         30         40         50         60 
MPLEYMGGRL ATLDDVDVRG KKVIVRFDLN SPVGNGGEIL DDSRIAEAAG TLRELCDRGA 

        70         80         90        100        110        120 
AVVALSHQGR PLESDFVSLE RHASLLSRYS GVEVRFVMDV IGPEALRTVA SLRPGEAVLL 

       130        140        150        160        170        180 
DNTRIISEDF IEAEGTVHAR GIMVTRLSKL ANMYVNEAFS ASHRSQASIV GFPYVLPSAG 

       190        200        210        220        230        240 
GRVLEKEIRS LNRAVSSGER PKVVVLGGAK LKDAVRIVDY LSSSGVADEV LTTGLVGLLF 

       250        260        270        280        290        300 
LYARGYRLPR DVTKLLEKKG GEEAIAKARR IVEEGRRVRT PIDFVVEVGD KIYIKPADEL 

       310        320        330        340        350        360 
TEGVPKDIGP STVEYFRAKM RGARVIVMRG PAGVIEDPRF RRGTVELVKA ALSSGAYTVF 

       370        380        390        400        410 
GGGHFRAILR DLPEHLSSKV GHLSTGGGAL LYYLSGRPLP GVKALVDSAR IFNLV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA79084.2.
PIRB72773.
RefSeqNP_147020.2. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YFS7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_0173.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA79084; BAA79084; APE_0173.1.
GeneID1445702.
KEGGape:APE_0173.1.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227108.
KOK00927.

Enzyme and pathway databases

BioCycAPER272557:GJD6-123-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_AERPE
AccessionPrimary (citable) accession number: Q9YFS7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 26, 2007
Last modified: June 11, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways