Reviewed, UniProtKB/Swiss-Prot Q9YFS7 (PGK_AERPE)

Names and origin

Protein names

Recommended name:
    Phosphoglycerate kinase
    EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	APE_0173.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP MF_00145
Subcellular location	Cytoplasm HAMAP MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 415	415	Phosphoglycerate kinase HAMAP MF_00145		PRO_0000146049
Regions
	Nucleotide binding	362 – 365	4	ATP By similarity
	Region	28 – 30	3	Substrate binding By similarity
	Region	67 – 70	4	Substrate binding By similarity
Sites
	Binding site	44	1	Substrate By similarity
	Binding site	124	1	Substrate By similarity
	Binding site	164	1	Substrate By similarity
	Binding site	336	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9YFS7-1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 710CBF57112A82CF	FASTA	415	44,902
	10 20 30 40 50 60 MPLEYMGGRL ATLDDVDVRG KKVIVRFDLN SPVGNGGEIL DDSRIAEAAG TLRELCDRGA 70 80 90 100 110 120 AVVALSHQGR PLESDFVSLE RHASLLSRYS GVEVRFVMDV IGPEALRTVA SLRPGEAVLL 130 140 150 160 170 180 DNTRIISEDF IEAEGTVHAR GIMVTRLSKL ANMYVNEAFS ASHRSQASIV GFPYVLPSAG 190 200 210 220 230 240 GRVLEKEIRS LNRAVSSGER PKVVVLGGAK LKDAVRIVDY LSSSGVADEV LTTGLVGLLF 250 260 270 280 290 300 LYARGYRLPR DVTKLLEKKG GEEAIAKARR IVEEGRRVRT PIDFVVEVGD KIYIKPADEL 310 320 330 340 350 360 TEGVPKDIGP STVEYFRAKM RGARVIVMRG PAGVIEDPRF RRGTVELVKA ALSSGAYTVF 370 380 390 400 410 GGGHFRAILR DLPEHLSSKV GHLSTGGGAL LYYLSGRPLP GVKALVDSAR IFNLV

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA79084.2.
PIR	B72773.
RefSeq	NP_147020.2.
3D structure databases
SMR	Q9YFS7. Positions 11-412.
ModBase	Search...
Genome annotation databases
GeneID	1445702.
GenomeReviews	Gene locus APE_0173.1 in contig BA000002_GR.
KEGG	ape:APE_0173.1.
NMPDR	fig|272557.1.peg.127.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG453500.
Enzyme and pathway databases
BioCyc	APER272557:APE0173-MONOMER.
BRENDA	2.7.2.3. 256344.
Family and domain databases
HAMAP	MF_00145. Phosphoglyc_kinase. [Tree]
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
PANTHER	PTHR11406. PGK. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PRINTS	PR00477. PHGLYCKINASE.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_AERPE

Accession

Primary (citable) accession number: Q9YFS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 26, 2007
Last modified:	January 19, 2010
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)