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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44SubstrateBy similarity1
Binding sitei124SubstrateBy similarity1
Binding sitei164SubstrateBy similarity1
Binding sitei336ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi362 – 365ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:APE_0173.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001460491 – 415Phosphoglycerate kinaseAdd BLAST415

Proteomic databases

PRIDEiQ9YFS7

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0173.1

Structurei

3D structure databases

ProteinModelPortaliQ9YFS7
SMRiQ9YFS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 30Substrate bindingBy similarity3
Regioni67 – 70Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG00496 Archaea
COG0126 LUCA
HOGENOMiHOG000227108
KOiK00927
OrthoDBiPOG093Z051V

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YFS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLEYMGGRL ATLDDVDVRG KKVIVRFDLN SPVGNGGEIL DDSRIAEAAG
60 70 80 90 100
TLRELCDRGA AVVALSHQGR PLESDFVSLE RHASLLSRYS GVEVRFVMDV
110 120 130 140 150
IGPEALRTVA SLRPGEAVLL DNTRIISEDF IEAEGTVHAR GIMVTRLSKL
160 170 180 190 200
ANMYVNEAFS ASHRSQASIV GFPYVLPSAG GRVLEKEIRS LNRAVSSGER
210 220 230 240 250
PKVVVLGGAK LKDAVRIVDY LSSSGVADEV LTTGLVGLLF LYARGYRLPR
260 270 280 290 300
DVTKLLEKKG GEEAIAKARR IVEEGRRVRT PIDFVVEVGD KIYIKPADEL
310 320 330 340 350
TEGVPKDIGP STVEYFRAKM RGARVIVMRG PAGVIEDPRF RRGTVELVKA
360 370 380 390 400
ALSSGAYTVF GGGHFRAILR DLPEHLSSKV GHLSTGGGAL LYYLSGRPLP
410
GVKALVDSAR IFNLV
Length:415
Mass (Da):44,902
Last modified:June 26, 2007 - v2
Checksum:i710CBF57112A82CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA79084.2
PIRiB72773

Genome annotation databases

EnsemblBacteriaiBAA79084; BAA79084; APE_0173.1
KEGGiape:APE_0173.1
PATRICifig|272557.25.peg.123

Similar proteinsi

Entry informationi

Entry nameiPGK_AERPE
AccessioniPrimary (citable) accession number: Q9YFS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 26, 2007
Last modified: May 23, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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