Reviewed,
UniProtKB/Swiss-Prot Q9YFI6 (PYRD_AERPE)
Last modified
November 4, 2008.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydroorotate dehydrogenase EC=1.3.3.1 Alternative name(s): Dihydroorotate oxidase DHOdehase Short name=DHODase Short name=DHOD | ||||
| Gene names |
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| Organism | Aeropyrum pernix [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 56636 [NCBI] | ||||
| Taxonomic lineage | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum |
Protein attributes
| Sequence length | 306 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-dihydroorotate + O(2) = orotate + H(2)O(2). |
| Cofactor | Binds 1 FMN per subunit By similarity. |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6. |
| Subunit structure | Heterotetramer of 2 pyrK and 2 pyrD subunits By similarity. |
| Subcellular location | CytoplasmBy similarity. |
| Sequence similarities | Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. |
Ontologies
Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: HAMAP |
| Molecular function | dihydroorotate oxidase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. Kikuchi H.DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1. |
Cross-references
Sequence databases | |
|---|---|
| BA000002 Genomic DNA. Translation: BAA79175.2. | |
| PIR | E72784. |
| RefSeq | NP_147090.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EP3 based on UniProtKB P54322. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1445772. |
| GenomeReviews | Gene locus APE_0260.1 in contig BA000002_GR. |
| KEGG | ape:APE_0260.1. |
| NMPDR | fig|272557.1.peg.197. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q9YFI6. |
Family and domain databases | |
| HAMAP | MF_00224. [Tree] |
| InterPro | IPR012135. DHO_DHase_1_2. IPR005720. DHO_DHase_1_core. IPR001295. Dihydroorotate_DHase_core. [Graphical view] |
| Pfam | PF01180. DHO_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000164. DHO_oxidase. 1 hit. |
| TIGRFAMs | TIGR01037. pyrD_sub1_fam. 1 hit. |
| PROSITE | PS00911. DHODEHASE_1. False negative. PS00912. DHODEHASE_2. False negative. [Graphical view] |
| BLOCKS | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | PYRD_AERPE | ||||||||
| Accession | Primary (citable) accession number: Q9YFI6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


