ID   Q9YFI0_AERPE            Unreviewed;       609 AA.
AC   Q9YFI0;
DT   01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT   14-NOV-2006, sequence version 2.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=aldehyde ferredoxin oxidoreductase {ECO:0000256|ARBA:ARBA00012818};
DE            EC=1.2.7.5 {ECO:0000256|ARBA:ARBA00012818};
GN   Name=aor {ECO:0000313|EMBL:BAA79181.2};
GN   OrderedLocusNames=APE_0266.1 {ECO:0000313|EMBL:BAA79181.2};
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557 {ECO:0000313|EMBL:BAA79181.2, ECO:0000313|Proteomes:UP000002518};
RN   [1] {ECO:0000313|EMBL:BAA79181.2, ECO:0000313|Proteomes:UP000002518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1
RC   {ECO:0000313|Proteomes:UP000002518};
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a
CC         carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:16421, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.2.7.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001714};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the AOR/FOR family.
CC       {ECO:0000256|ARBA:ARBA00011032}.
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DR   EMBL; BA000002; BAA79181.2; -; Genomic_DNA.
DR   PIR; C72785; C72785.
DR   AlphaFoldDB; Q9YFI0; -.
DR   STRING; 272557.APE_0266.1; -.
DR   EnsemblBacteria; BAA79181; BAA79181; APE_0266.1.
DR   KEGG; ape:APE_0266.1; -.
DR   eggNOG; arCOG00706; Archaea.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0033726; F:aldehyde ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.569.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2; 1.
DR   Gene3D; 1.10.599.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 3; 1.
DR   Gene3D; 3.60.9.10; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
DR   InterPro; IPR013984; Ald_Fedxn_OxRdtase_dom2.
DR   InterPro; IPR013985; Ald_Fedxn_OxRdtase_dom3.
DR   InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR   InterPro; IPR036503; Ald_Fedxn_OxRdtase_N_sf.
DR   InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR   InterPro; IPR036021; Tungsten_al_ferr_oxy-like_C.
DR   PANTHER; PTHR30038; ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR30038:SF7; TUNGSTEN-CONTAINING GLYCERALDEHYDE-3-PHOSPHATE:FERREDOXIN OXIDOREDUCTASE; 1.
DR   Pfam; PF01314; AFOR_C; 1.
DR   Pfam; PF02730; AFOR_N; 1.
DR   SMART; SM00790; AFOR_N; 1.
DR   SUPFAM; SSF48310; Aldehyde ferredoxin oxidoreductase, C-terminal domains; 1.
DR   SUPFAM; SSF56228; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002518}.
FT   DOMAIN          8..204
FT                   /note="Aldehyde ferredoxin oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00790"
FT   REGION          549..570
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   609 AA;  65409 MW;  CFA1F0F272B79E34 CRC64;
     MSNCPGGYNC RVALVNLNKL RIEAVDLDPE ALEYFPGGRA LGVALLYNLL GRYDSPLVLA
     TSPLVGSGFV MANRLTIVFK SPLTGTIAWA NTGGYVSPAL KKAGFDALVI VGRSREPHYL
     LIEDGSVDLL PAEDLWGLDA VEVALMLRRR HGDVRVLSIG PAGERGVSYA TVINDTGRSS
     GVRHGAGAVM GLKRLKAIAL KAKGVGSKAK PSDRSTLLRI SREIASRIMA SSLLNREKGL
     LAVYGTPVAM EALGPAEAVP HLNYRNPVLE RWEALSGRIM SKTILAGRLT CSSCPVACRR
     DTVGVSLSFR TEGPDYAQIS SLGSNTGLIS LEGVGYLTSL SYRLGLDPIE AGNILAMYAE
     ITELEDLGRE GLVWGDLEAM EKLLVSTAYR RGVGDLLAGG ARVVAEKLKR PEVRTDVKGV
     TIQNADPRVE KAWGVINSVE AFGGAAHIWV YGGIVASFKT LGVNVAVDWS FNPETTAKAV
     YEHQLLVAAA DTLQVCAFSQ YAAGWRDYAR ALSAVTGVKW SVEKLRGAAE TLLDLERLLN
     QQLGIEPTED VLPPKFTENP VPKGKHKGET ADVSSHIEEY YSLRNLKNGK IGSERMREAT
     SKAKAARIA
//