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Protein

dCTP deaminase

Gene

dcd

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115dCTPUniRule annotation1
Active sitei125Proton donor/acceptorUniRule annotation1
Binding sitei157dCTPUniRule annotation1
Binding sitei164dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi99 – 104dCTP bindingUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:APE_0333.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560261 – 178dCTP deaminaseAdd BLAST178

Proteomic databases

PRIDEiQ9YFA8

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_0333.1

Structurei

3D structure databases

ProteinModelPortaliQ9YFA8
SMRiQ9YFA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048 Archaea
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OrthoDBiPOG093Z0C6C

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YFA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDRDIRA LLAIGDLVVE PLSGDTVREN GLDLRLGRGF CRFKRSDRVL
60 70 80 90 100
DPRAPGSPGE FYECGEGDEI IVGPGEHMLL HTQEYIRLPG YVAGLVNLRS
110 120 130 140 150
TWARTGIYIP ATVVDAGFEG QLTIEVVGSG FPVKLYPGDR FLHLVLVKLQ
160 170
SPAMNPYRGR YQGQRGVRLP KLFAKNTG
Length:178
Mass (Da):19,653
Last modified:June 26, 2007 - v2
Checksum:iC54A7B095F7C8896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA79288.2
PIRiD72724

Genome annotation databases

EnsemblBacteriaiBAA79288; BAA79288; APE_0333.1
KEGGiape:APE_0333.1
PATRICifig|272557.25.peg.256

Similar proteinsi

Entry informationi

Entry nameiDCD_AERPE
AccessioniPrimary (citable) accession number: Q9YFA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 26, 2007
Last modified: April 25, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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