ID CDC61_AERPE Reviewed; 395 AA. AC Q9YEV6; DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot. DT 09-JAN-2007, sequence version 3. DT 27-MAR-2024, entry version 128. DE RecName: Full=ORC1-type DNA replication protein 1 {ECO:0000255|HAMAP-Rule:MF_01407}; DE AltName: Full=ORC1; GN Name=orc1; OrderedLocusNames=APE_0475.1; OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / OS K1). OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales; OC Desulfurococcaceae; Aeropyrum. OX NCBI_TaxID=272557; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1; RX PubMed=10382966; DOI=10.1093/dnares/6.2.83; RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., RA Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., RA Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S., RA Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., RA Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.; RT "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, RT Aeropyrum pernix K1."; RL DNA Res. 6:83-101(1999). RN [2] RP X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 9-395 IN COMPLEX WITH DNA AND ATP, RP FUNCTION, DNA-BINDING, AND DOMAIN. RX PubMed=17761880; DOI=10.1126/science.1143664; RA Gaudier M., Schuwirth B.S., Westcott S.L., Wigley D.B.; RT "Structural basis of DNA replication origin recognition by an ORC RT protein."; RL Science 317:1213-1216(2007). CC -!- FUNCTION: Involved in regulation of DNA replication (By similarity). CC Binds DNA. {ECO:0000255|HAMAP-Rule:MF_01407, CC ECO:0000269|PubMed:17761880}. CC -!- DOMAIN: Contains an N-terminal AAA+ ATPase domain and a C-terminal CC winged-helix (WH) domain. Domains are separated by a rigid linker. CC {ECO:0000269|PubMed:17761880}. CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP- CC Rule:MF_01407}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000002; BAA79440.2; -; Genomic_DNA. DR PIR; D72743; D72743. DR PDB; 2V1U; X-ray; 3.10 A; A=9-395. DR PDBsum; 2V1U; -. DR AlphaFoldDB; Q9YEV6; -. DR SMR; Q9YEV6; -. DR STRING; 272557.APE_0475.1; -. DR DNASU; 1444658; -. DR EnsemblBacteria; BAA79440; BAA79440; APE_0475.1. DR KEGG; ape:APE_0475.1; -. DR PATRIC; fig|272557.25.peg.363; -. DR eggNOG; arCOG00467; Archaea. DR EvolutionaryTrace; Q9YEV6; -. DR Proteomes; UP000002518; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule. DR CDD; cd00009; AAA; 1. DR CDD; cd08768; Cdc6_C; 1. DR Gene3D; 1.10.8.60; -; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR015163; Cdc6_C. DR InterPro; IPR014277; Orc1/Cdc6_arc. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR NCBIfam; TIGR02928; orc1/cdc6 family replication initiation protein; 1. DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1. DR PANTHER; PTHR10763:SF22; ORC1-TYPE DNA REPLICATION PROTEIN 3; 1. DR Pfam; PF13401; AAA_22; 1. DR Pfam; PF09079; Cdc6_C; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM01074; Cdc6_C; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. PE 1: Evidence at protein level; KW 3D-structure; ATP-binding; DNA replication; DNA-binding; KW Nucleotide-binding; Reference proteome. FT CHAIN 1..395 FT /note="ORC1-type DNA replication protein 1" FT /id="PRO_0000150981" FT BINDING 63..67 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407, FT ECO:0000269|PubMed:17761880" FT BINDING 209 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407, FT ECO:0000269|PubMed:17761880" FT BINDING 221 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407, FT ECO:0000269|PubMed:17761880" FT STRAND 12..15 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 17..20 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 33..41 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 44..46 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 55..57 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 65..83 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 87..93 FT /evidence="ECO:0007829|PDB:2V1U" FT TURN 94..96 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 100..111 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 122..133 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 138..145 FT /evidence="ECO:0007829|PDB:2V1U" FT TURN 146..148 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 149..152 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 156..165 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 166..168 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 177..181 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 188..191 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 193..196 FT /evidence="ECO:0007829|PDB:2V1U" FT TURN 197..200 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 201..203 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 211..225 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 235..244 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 245..247 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 250..266 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 274..294 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 298..310 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 311..314 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 319..332 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 340..352 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 355..362 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 364..366 FT /evidence="ECO:0007829|PDB:2V1U" FT STRAND 368..374 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 378..387 FT /evidence="ECO:0007829|PDB:2V1U" FT HELIX 391..394 FT /evidence="ECO:0007829|PDB:2V1U" SQ SEQUENCE 395 AA; 44313 MW; 999C820FE499C145 CRC64; MEEVFTAALE SKIFRKRWVL LPDYVPDVLP HREAELRRLA EVLAPALRGE KPSNALLYGL TGTGKTAVAR LVLRRLEARA SSLGVLVKPI YVNARHRETP YRVASAIAEA VGVRVPFTGL SVGEVYERLV KRLSRLRGIY IIVLDEIDFL PKRPGGQDLL YRITRINQEL GDRVWVSLVG ITNSLGFVEN LEPRVKSSLG EVELVFPPYT APQLRDILET RAEEAFNPGV LDPDVVPLCA ALAAREHGDA RRALDLLRVA GEIAERRREE RVRREHVYSA RAEIERDRVS EVVRTLPLHA KLVLLSIMML EDGGRPASTG EIYERYKELT STLGLEHVTL RRVSGIISEL DMLGIVKSRV VSRGRYGKTR EVSLDADRLA VENALSEDPF VARLL //