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Q9YEV6 (CDC61_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ORC1-type DNA replication protein 1
Alternative name(s):
ORC1
Gene names
Name:orc1
Ordered Locus Names:APE_0475.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in regulation of DNA replication By similarity. Binds DNA. Ref.2

Domain

Contains an N-terminal AAA+ ATPase domain and a C-terminal winged-helix (WH) domain. Domains are separated by a rigid linker. Ref.2

Sequence similarities

Belongs to the CDC6/cdc18 family.

Ontologies

Keywords
   Biological processDNA replication
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395ORC1-type DNA replication protein 1 HAMAP-Rule MF_01407
PRO_0000150981

Regions

Nucleotide binding63 – 675ATP HAMAP-Rule MF_01407

Sites

Binding site2091ATP
Binding site2211ATP

Secondary structure

............................................................. 395
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9YEV6 [UniParc].

Last modified January 9, 2007. Version 3.
Checksum: 999C820FE499C145

FASTA39544,313
        10         20         30         40         50         60 
MEEVFTAALE SKIFRKRWVL LPDYVPDVLP HREAELRRLA EVLAPALRGE KPSNALLYGL 

        70         80         90        100        110        120 
TGTGKTAVAR LVLRRLEARA SSLGVLVKPI YVNARHRETP YRVASAIAEA VGVRVPFTGL 

       130        140        150        160        170        180 
SVGEVYERLV KRLSRLRGIY IIVLDEIDFL PKRPGGQDLL YRITRINQEL GDRVWVSLVG 

       190        200        210        220        230        240 
ITNSLGFVEN LEPRVKSSLG EVELVFPPYT APQLRDILET RAEEAFNPGV LDPDVVPLCA 

       250        260        270        280        290        300 
ALAAREHGDA RRALDLLRVA GEIAERRREE RVRREHVYSA RAEIERDRVS EVVRTLPLHA 

       310        320        330        340        350        360 
KLVLLSIMML EDGGRPASTG EIYERYKELT STLGLEHVTL RRVSGIISEL DMLGIVKSRV 

       370        380        390 
VSRGRYGKTR EVSLDADRLA VENALSEDPF VARLL 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1."
Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. expand/collapse author list , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.
DNA Res. 6:83-101(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.
[2]"Structural basis of DNA replication origin recognition by an ORC protein."
Gaudier M., Schuwirth B.S., Westcott S.L., Wigley D.B.
Science 317:1213-1216(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 9-395 IN COMPLEX WITH DNA AND ATP, FUNCTION, DNA-BINDING, DOMAIN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA79440.2.
PIRD72743.
RefSeqNP_147262.2. NC_000854.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2V1UX-ray3.10A9-395[»]
ProteinModelPortalQ9YEV6.
SMRQ9YEV6. Positions 9-395.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_0475.1.

Proteomic databases

PRIDEQ9YEV6.

Protocols and materials databases

DNASU1444658.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA79440; BAA79440; APE_0475.1.
GeneID1444658.
KEGGape:APE_0475.1.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1474.
HOGENOMHOG000230140.
KOK10725.
OMATPHLPPC.
ProtClustDBCLSK2782470.

Enzyme and pathway databases

BioCycAPER272557:GJD6-365-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_01407. ORC1_type_DNA_replic_protein.
InterProIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C_dom.
IPR014277. Orc1/Cdc6_arc.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR10763:SF8. PTHR10763:SF8. 1 hit.
PfamPF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR02928. TIGR02928. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9YEV6.

Entry information

Entry nameCDC61_AERPE
AccessionPrimary (citable) accession number: Q9YEV6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references