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Q9YEV6

- CDC61_AERPE

UniProt

Q9YEV6 - CDC61_AERPE

Protein

ORC1-type DNA replication protein 1

Gene

orc1

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 3 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in regulation of DNA replication By similarity. Binds DNA.1 PublicationUniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei209 – 2091ATP1 PublicationUniRule annotation
    Binding sitei221 – 2211ATP1 PublicationUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 675ATP1 PublicationUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-KW
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. DNA replication Source: UniProtKB-HAMAP

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAPER272557:GJD6-365-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ORC1-type DNA replication protein 1UniRule annotation
    Alternative name(s):
    ORC1
    Gene namesi
    Name:orc1
    Ordered Locus Names:APE_0475.1
    OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
    Taxonomic identifieri272557 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
    ProteomesiUP000002518: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395ORC1-type DNA replication protein 1PRO_0000150981Add
    BLAST

    Proteomic databases

    PRIDEiQ9YEV6.

    Interactioni

    Protein-protein interaction databases

    STRINGi272557.APE_0475.1.

    Structurei

    Secondary structure

    1
    395
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi12 – 154
    Helixi17 – 204
    Helixi33 – 419
    Helixi44 – 463
    Beta strandi55 – 573
    Helixi65 – 8319
    Beta strandi87 – 937
    Turni94 – 963
    Helixi100 – 11112
    Helixi122 – 13312
    Beta strandi138 – 1458
    Turni146 – 1483
    Helixi149 – 1524
    Helixi156 – 16510
    Helixi166 – 1683
    Beta strandi177 – 1815
    Beta strandi188 – 1914
    Helixi193 – 1964
    Turni197 – 2004
    Beta strandi201 – 2033
    Helixi211 – 22515
    Helixi235 – 24410
    Beta strandi245 – 2473
    Helixi250 – 26617
    Helixi274 – 29421
    Helixi298 – 31013
    Beta strandi311 – 3144
    Helixi319 – 33214
    Helixi340 – 35213
    Beta strandi355 – 3628
    Helixi364 – 3663
    Beta strandi368 – 3747
    Helixi378 – 38710
    Helixi391 – 3944

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2V1UX-ray3.10A9-395[»]
    ProteinModelPortaliQ9YEV6.
    SMRiQ9YEV6. Positions 9-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9YEV6.

    Family & Domainsi

    Domaini

    Contains an N-terminal AAA+ ATPase domain and a C-terminal winged-helix (WH) domain. Domains are separated by a rigid linker.1 Publication

    Sequence similaritiesi

    Belongs to the CDC6/cdc18 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1474.
    HOGENOMiHOG000230140.
    KOiK10725.
    OMAiPYTRNQI.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01407. ORC1_type_DNA_replic_protein.
    InterProiIPR003593. AAA+_ATPase.
    IPR015163. Cdc6_C_dom.
    IPR014277. Orc1/Cdc6_arc.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF09079. Cdc6_C. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01074. Cdc6_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR02928. TIGR02928. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9YEV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEVFTAALE SKIFRKRWVL LPDYVPDVLP HREAELRRLA EVLAPALRGE    50
    KPSNALLYGL TGTGKTAVAR LVLRRLEARA SSLGVLVKPI YVNARHRETP 100
    YRVASAIAEA VGVRVPFTGL SVGEVYERLV KRLSRLRGIY IIVLDEIDFL 150
    PKRPGGQDLL YRITRINQEL GDRVWVSLVG ITNSLGFVEN LEPRVKSSLG 200
    EVELVFPPYT APQLRDILET RAEEAFNPGV LDPDVVPLCA ALAAREHGDA 250
    RRALDLLRVA GEIAERRREE RVRREHVYSA RAEIERDRVS EVVRTLPLHA 300
    KLVLLSIMML EDGGRPASTG EIYERYKELT STLGLEHVTL RRVSGIISEL 350
    DMLGIVKSRV VSRGRYGKTR EVSLDADRLA VENALSEDPF VARLL 395
    Length:395
    Mass (Da):44,313
    Last modified:January 9, 2007 - v3
    Checksum:i999C820FE499C145
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA79440.2.
    PIRiD72743.
    RefSeqiNP_147262.2. NC_000854.2.

    Genome annotation databases

    EnsemblBacteriaiBAA79440; BAA79440; APE_0475.1.
    GeneIDi1444658.
    KEGGiape:APE_0475.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA79440.2 .
    PIRi D72743.
    RefSeqi NP_147262.2. NC_000854.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2V1U X-ray 3.10 A 9-395 [» ]
    ProteinModelPortali Q9YEV6.
    SMRi Q9YEV6. Positions 9-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272557.APE_0475.1.

    Proteomic databases

    PRIDEi Q9YEV6.

    Protocols and materials databases

    DNASUi 1444658.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA79440 ; BAA79440 ; APE_0475.1 .
    GeneIDi 1444658.
    KEGGi ape:APE_0475.1.

    Phylogenomic databases

    eggNOGi COG1474.
    HOGENOMi HOG000230140.
    KOi K10725.
    OMAi PYTRNQI.

    Enzyme and pathway databases

    BioCyci APER272557:GJD6-365-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9YEV6.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01407. ORC1_type_DNA_replic_protein.
    InterProi IPR003593. AAA+_ATPase.
    IPR015163. Cdc6_C_dom.
    IPR014277. Orc1/Cdc6_arc.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF09079. Cdc6_C. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01074. Cdc6_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR02928. TIGR02928. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.
    2. "Structural basis of DNA replication origin recognition by an ORC protein."
      Gaudier M., Schuwirth B.S., Westcott S.L., Wigley D.B.
      Science 317:1213-1216(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 9-395 IN COMPLEX WITH DNA AND ATP, FUNCTION, DNA-BINDING, DOMAIN.

    Entry informationi

    Entry nameiCDC61_AERPE
    AccessioniPrimary (citable) accession number: Q9YEV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3