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Q9YEV6

- CDC61_AERPE

UniProt

Q9YEV6 - CDC61_AERPE

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Protein

ORC1-type DNA replication protein 1

Gene
orc1, APE_0475.1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in regulation of DNA replication By similarity. Binds DNA.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei209 – 2091ATP
Binding sitei221 – 2211ATP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 675ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-KW
  3. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-365-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ORC1-type DNA replication protein 1
Alternative name(s):
ORC1
Gene namesi
Name:orc1
Ordered Locus Names:APE_0475.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395ORC1-type DNA replication protein 1UniRule annotationPRO_0000150981Add
BLAST

Proteomic databases

PRIDEiQ9YEV6.

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0475.1.

Structurei

Secondary structure

1
395
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 154
Helixi17 – 204
Helixi33 – 419
Helixi44 – 463
Beta strandi55 – 573
Helixi65 – 8319
Beta strandi87 – 937
Turni94 – 963
Helixi100 – 11112
Helixi122 – 13312
Beta strandi138 – 1458
Turni146 – 1483
Helixi149 – 1524
Helixi156 – 16510
Helixi166 – 1683
Beta strandi177 – 1815
Beta strandi188 – 1914
Helixi193 – 1964
Turni197 – 2004
Beta strandi201 – 2033
Helixi211 – 22515
Helixi235 – 24410
Beta strandi245 – 2473
Helixi250 – 26617
Helixi274 – 29421
Helixi298 – 31013
Beta strandi311 – 3144
Helixi319 – 33214
Helixi340 – 35213
Beta strandi355 – 3628
Helixi364 – 3663
Beta strandi368 – 3747
Helixi378 – 38710
Helixi391 – 3944

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V1UX-ray3.10A9-395[»]
ProteinModelPortaliQ9YEV6.
SMRiQ9YEV6. Positions 9-395.

Miscellaneous databases

EvolutionaryTraceiQ9YEV6.

Family & Domainsi

Domaini

Contains an N-terminal AAA+ ATPase domain and a C-terminal winged-helix (WH) domain. Domains are separated by a rigid linker.1 Publication

Sequence similaritiesi

Belongs to the CDC6/cdc18 family.

Phylogenomic databases

eggNOGiCOG1474.
HOGENOMiHOG000230140.
KOiK10725.
OMAiPYTRNQI.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01407. ORC1_type_DNA_replic_protein.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C_dom.
IPR014277. Orc1/Cdc6_arc.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02928. TIGR02928. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YEV6-1 [UniParc]FASTAAdd to Basket

« Hide

MEEVFTAALE SKIFRKRWVL LPDYVPDVLP HREAELRRLA EVLAPALRGE    50
KPSNALLYGL TGTGKTAVAR LVLRRLEARA SSLGVLVKPI YVNARHRETP 100
YRVASAIAEA VGVRVPFTGL SVGEVYERLV KRLSRLRGIY IIVLDEIDFL 150
PKRPGGQDLL YRITRINQEL GDRVWVSLVG ITNSLGFVEN LEPRVKSSLG 200
EVELVFPPYT APQLRDILET RAEEAFNPGV LDPDVVPLCA ALAAREHGDA 250
RRALDLLRVA GEIAERRREE RVRREHVYSA RAEIERDRVS EVVRTLPLHA 300
KLVLLSIMML EDGGRPASTG EIYERYKELT STLGLEHVTL RRVSGIISEL 350
DMLGIVKSRV VSRGRYGKTR EVSLDADRLA VENALSEDPF VARLL 395
Length:395
Mass (Da):44,313
Last modified:January 9, 2007 - v3
Checksum:i999C820FE499C145
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA79440.2.
PIRiD72743.
RefSeqiNP_147262.2. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA79440; BAA79440; APE_0475.1.
GeneIDi1444658.
KEGGiape:APE_0475.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA79440.2 .
PIRi D72743.
RefSeqi NP_147262.2. NC_000854.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2V1U X-ray 3.10 A 9-395 [» ]
ProteinModelPortali Q9YEV6.
SMRi Q9YEV6. Positions 9-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_0475.1.

Proteomic databases

PRIDEi Q9YEV6.

Protocols and materials databases

DNASUi 1444658.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA79440 ; BAA79440 ; APE_0475.1 .
GeneIDi 1444658.
KEGGi ape:APE_0475.1.

Phylogenomic databases

eggNOGi COG1474.
HOGENOMi HOG000230140.
KOi K10725.
OMAi PYTRNQI.

Enzyme and pathway databases

BioCyci APER272557:GJD6-365-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9YEV6.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01407. ORC1_type_DNA_replic_protein.
InterProi IPR003593. AAA+_ATPase.
IPR015163. Cdc6_C_dom.
IPR014277. Orc1/Cdc6_arc.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF09079. Cdc6_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR02928. TIGR02928. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.
  2. "Structural basis of DNA replication origin recognition by an ORC protein."
    Gaudier M., Schuwirth B.S., Westcott S.L., Wigley D.B.
    Science 317:1213-1216(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 9-395 IN COMPLEX WITH DNA AND ATP, FUNCTION, DNA-BINDING, DOMAIN.

Entry informationi

Entry nameiCDC61_AERPE
AccessioniPrimary (citable) accession number: Q9YEV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 9, 2007
Last modified: June 11, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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