Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ORC1-type DNA replication protein 1

Gene

orc1

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of DNA replication (By similarity). Binds DNA.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei209ATPUniRule annotation1 Publication1
Binding sitei221ATPUniRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 67ATPUniRule annotation1 Publication5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ORC1-type DNA replication protein 1UniRule annotation
Alternative name(s):
ORC1
Gene namesi
Name:orc1
Ordered Locus Names:APE_0475.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509811 – 395ORC1-type DNA replication protein 1Add BLAST395

Proteomic databases

PRIDEiQ9YEV6.

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0475.1.

Structurei

Secondary structure

1395
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 15Combined sources4
Helixi17 – 20Combined sources4
Helixi33 – 41Combined sources9
Helixi44 – 46Combined sources3
Beta strandi55 – 57Combined sources3
Helixi65 – 83Combined sources19
Beta strandi87 – 93Combined sources7
Turni94 – 96Combined sources3
Helixi100 – 111Combined sources12
Helixi122 – 133Combined sources12
Beta strandi138 – 145Combined sources8
Turni146 – 148Combined sources3
Helixi149 – 152Combined sources4
Helixi156 – 165Combined sources10
Helixi166 – 168Combined sources3
Beta strandi177 – 181Combined sources5
Beta strandi188 – 191Combined sources4
Helixi193 – 196Combined sources4
Turni197 – 200Combined sources4
Beta strandi201 – 203Combined sources3
Helixi211 – 225Combined sources15
Helixi235 – 244Combined sources10
Beta strandi245 – 247Combined sources3
Helixi250 – 266Combined sources17
Helixi274 – 294Combined sources21
Helixi298 – 310Combined sources13
Beta strandi311 – 314Combined sources4
Helixi319 – 332Combined sources14
Helixi340 – 352Combined sources13
Beta strandi355 – 362Combined sources8
Helixi364 – 366Combined sources3
Beta strandi368 – 374Combined sources7
Helixi378 – 387Combined sources10
Helixi391 – 394Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V1UX-ray3.10A9-395[»]
ProteinModelPortaliQ9YEV6.
SMRiQ9YEV6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YEV6.

Family & Domainsi

Domaini

Contains an N-terminal AAA+ ATPase domain and a C-terminal winged-helix (WH) domain. Domains are separated by a rigid linker.1 Publication

Sequence similaritiesi

Belongs to the CDC6/cdc18 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00467. Archaea.
COG1474. LUCA.
HOGENOMiHOG000230140.
KOiK10725.
OMAiTGWPTDQ.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01407. ORC1_type_DNA_replic_protein. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C.
IPR014277. Orc1/Cdc6_arc.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02928. TIGR02928. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YEV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVFTAALE SKIFRKRWVL LPDYVPDVLP HREAELRRLA EVLAPALRGE
60 70 80 90 100
KPSNALLYGL TGTGKTAVAR LVLRRLEARA SSLGVLVKPI YVNARHRETP
110 120 130 140 150
YRVASAIAEA VGVRVPFTGL SVGEVYERLV KRLSRLRGIY IIVLDEIDFL
160 170 180 190 200
PKRPGGQDLL YRITRINQEL GDRVWVSLVG ITNSLGFVEN LEPRVKSSLG
210 220 230 240 250
EVELVFPPYT APQLRDILET RAEEAFNPGV LDPDVVPLCA ALAAREHGDA
260 270 280 290 300
RRALDLLRVA GEIAERRREE RVRREHVYSA RAEIERDRVS EVVRTLPLHA
310 320 330 340 350
KLVLLSIMML EDGGRPASTG EIYERYKELT STLGLEHVTL RRVSGIISEL
360 370 380 390
DMLGIVKSRV VSRGRYGKTR EVSLDADRLA VENALSEDPF VARLL
Length:395
Mass (Da):44,313
Last modified:January 9, 2007 - v3
Checksum:i999C820FE499C145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79440.2.
PIRiD72743.

Genome annotation databases

EnsemblBacteriaiBAA79440; BAA79440; APE_0475.1.
KEGGiape:APE_0475.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79440.2.
PIRiD72743.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V1UX-ray3.10A9-395[»]
ProteinModelPortaliQ9YEV6.
SMRiQ9YEV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_0475.1.

Proteomic databases

PRIDEiQ9YEV6.

Protocols and materials databases

DNASUi1444658.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA79440; BAA79440; APE_0475.1.
KEGGiape:APE_0475.1.

Phylogenomic databases

eggNOGiarCOG00467. Archaea.
COG1474. LUCA.
HOGENOMiHOG000230140.
KOiK10725.
OMAiTGWPTDQ.

Miscellaneous databases

EvolutionaryTraceiQ9YEV6.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01407. ORC1_type_DNA_replic_protein. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C.
IPR014277. Orc1/Cdc6_arc.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02928. TIGR02928. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDC61_AERPE
AccessioniPrimary (citable) accession number: Q9YEV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.