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Protein

RNA 3'-terminal phosphate cyclase

Gene

rtcA

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).By similarity

Catalytic activityi

ATP + (RNA)-3'-(3'-phospho-ribonucleoside) = AMP + diphosphate + (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105ATPBy similarity1
Active sitei321Tele-AMP-histidine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi295 – 298ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclase (EC:6.5.1.4)
Short name:
RNA cyclase
Short name:
RNA-3'-phosphate cyclase
Gene namesi
Name:rtcA
Ordered Locus Names:APE_0511.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564221 – 361RNA 3'-terminal phosphate cyclaseAdd BLAST361

Proteomic databases

PRIDEiQ9YES0

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0511.1

Structurei

3D structure databases

ProteinModelPortaliQ9YES0
SMRiQ9YES0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04125 Archaea
COG0430 LUCA
HOGENOMiHOG000015264
KOiK01974
OrthoDBiPOG093Z05RD

Family and domain databases

Gene3Di3.30.360.20, 1 hit
3.65.10.20, 2 hits
HAMAPiMF_00200 RTC, 1 hit
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR017770 RNA3'_term_phos_cyc_type_1
IPR020719 RNA3'_term_phos_cycl-like_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF0 PTHR11096:SF0, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
SUPFAMiSSF52913 SSF52913, 1 hit
SSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR03399 RNA_3prim_cycl, 1 hit
PROSITEiView protein in PROSITE
PS01287 RTC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YES0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGEWVVVD GSMGEGGGQI LRTAVALAAV LGRPLRIVNI RAKRRPPGLR
60 70 80 90 100
PQHLTAVRAV AAISGGRLRG AEVGSTSLEF TPGRVRGGRY RFDVGTAGSV
110 120 130 140 150
ALIIQALAPL LAYSDSPVEV ELTGGTDVPM APTIDYMREV FASILAMLGY
160 170 180 190 200
EIEIRVLRRG HYPRGGGRVV VRVPDPPGGF RARSFVERGP LKGVYVRSHA
210 220 230 240 250
VKLPGSIAER QARSAASLVR ERLGVDPIVE IEAYKPHRDP HLGPGTGVLV
260 270 280 290 300
WAVFGETVMG GDSIGKKGKP AEVVGREAAE SLLEDMATGA ALDRHMSDMA
310 320 330 340 350
PVYLALAGGV STVFGARLTG HASTILELLR IMVDGFEYRI LEGGLERPFK
360
AELRGAGVSP R
Length:361
Mass (Da):38,290
Last modified:June 26, 2007 - v2
Checksum:iB2E8BFE6CF844708
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA79476.2
PIRiH72747

Genome annotation databases

EnsemblBacteriaiBAA79476; BAA79476; APE_0511.1
KEGGiape:APE_0511.1
PATRICifig|272557.25.peg.386

Similar proteinsi

Entry informationi

Entry nameiRTCA_AERPE
AccessioniPrimary (citable) accession number: Q9YES0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 26, 2007
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health