Reviewed, UniProtKB/Swiss-Prot Q9YER8 (NADM_AERPE)

Names and origin

Protein names

Recommended name:
    Nicotinamide-nucleotide adenylyltransferase
    EC=2.7.7.1
Alternative name(s):
    NAD(+) pyrophosphorylase
    NAD(+) diphosphorylase
    NMN adenylyltransferase

Gene names

Ordered Locus Names:

APE_0513.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + nicotinamide ribonucleotide = diphosphate + NAD+. HAMAP MF_00243
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide ribonucleotide: step 1/1. HAMAP MF_00243
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the archaeal NMN adenylyltransferase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinamide-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Nicotinamide-nucleotide adenylyltransferase HAMAP MF_00243		PRO_0000134987

Sequences

	Sequence		Length	Mass (Da)
	Q9YER8-1 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: E100C434A2064E4A	FASTA	172	19,828
	10 20 30 40 50 60 MKRLLVVGRF QPPHLGHLHT IKWALGRAEE VIVVVGSAQE SYTLENPMTA GERVHALRLM 70 80 90 100 110 120 LEELDDWCRR LMIAPVPDIA MNKVWVQYLK MLLPPFDGVV SGNELVLMLF EDMGLAALRP 130 140 150 160 170 PMFRRGECSG TRIRRLMASG ESGWEDCLHP QVRRYVEEIG LPERLRRLQE MR

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA79478.2.
PIR	B72748.
RefSeq	NP_147292.2.
3D structure databases
HSSP	HSSP built from PDB template 1F9A based on UniProtKB Q57961.
ModBase	Search...
Genome annotation databases
GeneID	1444691.
GenomeReviews	Gene locus APE_0513.1 in contig BA000002_GR.
KEGG	ape:APE_0513.1.
NMPDR	fig|272557.1.peg.400.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YER8.
OMA	Q9YER8. IGRFQPY.
Enzyme and pathway databases
BRENDA	2.7.7.1. 256344.
Family and domain databases
HAMAP	MF_00243. [Tree]
InterPro	IPR004821. Cyt_trans_rel. IPR004820. Cytidylyltransf. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADM_AERPE

Accession

Primary (citable) accession number: Q9YER8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	June 16, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)