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Reviewed, UniProtKB/Swiss-Prot Q9YER8 (NADM_AERPE)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Nicotinamide-nucleotide adenylyltransferase
    EC=2.7.7.1
Alternative name(s):
    NAD(+) pyrophosphorylase
    NAD(+) diphosphorylase
    NMN adenylyltransferase
Gene names
Ordered Locus Names: APE_0513.1
OrganismAeropyrum pernix [Complete proteome] [HAMAP]
Taxonomic identifier56636 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

ATP + nicotinamide ribonucleotide = diphosphate + NAD+. HAMAP MF_00243

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide ribonucleotide: step 1/1. HAMAP MF_00243

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the archaeal NMN adenylyltransferase family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
NAD
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nicotinamide-nucleotide adenylyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172Nicotinamide-nucleotide adenylyltransferase HAMAP MF_00243
PRO_0000134987

Sequences

Sequence LengthMass (Da)Tools
Q9YER8-1 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: E100C434A2064E4A

FASTA17219,828
        10         20         30         40         50         60 
MKRLLVVGRF QPPHLGHLHT IKWALGRAEE VIVVVGSAQE SYTLENPMTA GERVHALRLM 

        70         80         90        100        110        120 
LEELDDWCRR LMIAPVPDIA MNKVWVQYLK MLLPPFDGVV SGNELVLMLF EDMGLAALRP 

       130        140        150        160        170 
PMFRRGECSG TRIRRLMASG ESGWEDCLHP QVRRYVEEIG LPERLRRLQE MR 

« Hide

References

[1]"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1."
Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. expand/collapse author list , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.
DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K1.

Cross-references

Sequence databases

BA000002 Genomic DNA. Translation: BAA79478.2.
PIRB72748.
RefSeqNP_147292.2.

3D structure databases

HSSPHSSP built from PDB template 1F9A based on UniProtKB Q57961.
ModBaseSearch...

Genome annotation databases

GeneID1444691.
GenomeReviewsGene locus APE_0513.1 in contig BA000002_GR.
KEGGape:APE_0513.1.
NMPDRfig|272557.1.peg.400.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9YER8.
OMAQ9YER8. IGRFQPY.

Enzyme and pathway databases

BRENDA2.7.7.1. 256344.

Family and domain databases

HAMAPMF_00243.
[Tree]
InterProIPR004821. Cyt_trans_rel.
IPR004820. Cytidylyltransf.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PfamPF01467. CTP_transf_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00125. cyt_tran_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADM_AERPE
AccessionPrimary (citable) accession number: Q9YER8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 16, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents