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Q9YER8 (NADM_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nicotinamide-nucleotide adenylyltransferase

EC=2.7.7.1
Alternative name(s):
NAD(+) diphosphorylase
NAD(+) pyrophosphorylase
NMN adenylyltransferase
Gene names
Ordered Locus Names:APE_0513.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + nicotinamide ribonucleotide = diphosphate + NAD+. HAMAP MF_00243

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. HAMAP MF_00243

Subcellular location

Cytoplasm By similarity HAMAP MF_00243.

Sequence similarities

Belongs to the archaeal NMN adenylyltransferase family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
NAD
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nicotinamide-nucleotide adenylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172Nicotinamide-nucleotide adenylyltransferase HAMAP MF_00243
PRO_0000134987

Sequences

Sequence LengthMass (Da)Tools
Q9YER8 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: E100C434A2064E4A

FASTA17219,828
        10         20         30         40         50         60 
MKRLLVVGRF QPPHLGHLHT IKWALGRAEE VIVVVGSAQE SYTLENPMTA GERVHALRLM 

        70         80         90        100        110        120 
LEELDDWCRR LMIAPVPDIA MNKVWVQYLK MLLPPFDGVV SGNELVLMLF EDMGLAALRP 

       130        140        150        160        170 
PMFRRGECSG TRIRRLMASG ESGWEDCLHP QVRRYVEEIG LPERLRRLQE MR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA79478.2.
PIRB72748.
RefSeqNP_147292.2. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YER8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1444691.
GenomeReviewsGene locus APE_0513.1 in contig BA000002_GR.
KEGGape:APE_0513.1.
NMPDRfig|272557.1.peg.400.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG392019.
OMAFHKGHLE.
ProtClustDBCLSK2782474.

Enzyme and pathway databases

BioCycAPER272557:APE0513-MONOMER.

Family and domain databases

HAMAPMF_00243. NMN_adenylyltr.
[Tree]
InterProIPR004821. Cyt_trans-rel.
IPR004820. Cytidylyltransf.
IPR006418. NMN_Atrans_arc.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK00952.
PfamPF01467. CTP_transf_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00125. Cyt_tran_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADM_AERPE
AccessionPrimary (citable) accession number: Q9YER8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 16, 2011
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families