Reviewed, UniProtKB/Swiss-Prot Q9YEK6 (AROK_AERPE)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	APE_0572

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00370
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00370
Subcellular location	Cytoplasm Probable HAMAP MF_00370.
Sequence similarities	Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Shikimate kinase HAMAP MF_00370		PRO_0000141570
Regions
	Nucleotide binding	86 – 96	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9YEK6-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: B19A7E01C8CECCE7	FASTA	280	28,561
	10 20 30 40 50 60 MARARASGGL TIVNAIGHGR LGGAAGLGLW VESRVREARG LWAGVSLTPR GERRLPPRVL 70 80 90 100 110 120 EAAATAACSL GACVEGLEAE VHTGFPPGVG LKGSAALLAS LVEAVLRLKG VRAPPWRAAL 130 140 150 160 170 180 AAARVSRGAG LSVTGALDDH AASLLEAPVI TDNRGMAILR LLPRDGCRLT AVIGVPGVEN 190 200 210 220 230 240 PVENLDPSPF RRHSRLYDAA ARLGLAGEWL PAMAVSGVAG ALALGVEGLA SRLYEAGAAA 250 260 270 280 AGVTGKGPAV FALTERPRGA AEVLETAGYE VVEARFKWCG

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA79540.1.
PIR	D72642.
RefSeq	NP_147333.1.
3D structure databases
SMR	Q9YEK6. Positions 75-269.
ModBase	Search...
Genome annotation databases
GeneID	1444732.
GenomeReviews	Gene locus APE_0572 in contig BA000002_GR.
KEGG	ape:APE_0572.
NMPDR	fig|272557.1.peg.441.
Organism-specific databases
CMR	Search...
Enzyme and pathway databases
BioCyc	APER272557:APE0572-MONOMER.
BRENDA	2.7.1.71. 256344.
Family and domain databases
HAMAP	MF_00370. Shik_kinase_arch. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR010189. SK_arc. [Graphical view]
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF005758. Shikimt_kin_arch. 1 hit.
TIGRFAMs	TIGR01920. Shik_kin_archae. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_AERPE

Accession

Primary (citable) accession number: Q9YEK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	November 1, 1999
Last modified:	February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)