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Q9YEJ9 (AROB_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:APE_0579
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3583583-dehydroquinate synthase HAMAP MF_00110
PRO_0000140815

Sequences

Sequence LengthMass (Da)Tools
Q9YEJ9 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 45EFBCEB9A33DBD4

FASTA35837,446
        10         20         30         40         50         60 
MAQAAVERRV FRLSVDEETV VAAGVGALSE APRAAGGTAY IVHEEALSAE AARLARILEA 

        70         80         90        100        110        120 
RGVEVLGAVA GGGERVKSLD WVTRLWDLML QAGVERSTTV YIIGGGALLD AAGFAASTLM 

       130        140        150        160        170        180 
RGLSTVNIPS TTLAAFDAAA GGKTGVNLRG KNMVGTFHNP RMVLVEPGIV AGQPDEGYRD 

       190        200        210        220        230        240 
GFAELVKHVA LSGDREPAAS LLPQALARRP APLARLAFWS LGYKMQVVAG DPRERGLRRI 

       250        260        270        280        290        300 
LNLGHTIGHA LEAASSYTLS HGRSVSIGLA GELELSRRLA GLPRGEAEDV LDMLSTAGLP 

       310        320        330        340        350 
LEPPPGLAGE AAGLVGLDKK REGGSIVMPL LERLGRPRLS RVPVETVSRL MVELWGGG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000002 Genomic DNA. Translation: BAA79547.1.
PIRC72643.
RefSeqNP_147337.1. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YEJ9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1444736.
GenomeReviewsGene locus APE_0579 in contig BA000002_GR.
KEGGape:APE_0579.
NMPDRfig|272557.1.peg.445.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMATERMISD.
PhylomeDBQ9YEJ9.

Enzyme and pathway databases

BioCycAPER272557:APE0579-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_AERPE
AccessionPrimary (citable) accession number: Q9YEJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: December 14, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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