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Protein
Submitted name:

Isocitrate dehydrogenase [NADP]

Gene

APE_0689.1

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191NADPCombined sources
Binding sitei232 – 2321NADPCombined sources
Binding sitei353 – 3531NADP; via amide nitrogen and carbonyl oxygenCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1093NADPCombined sources
Nucleotide bindingi288 – 2892NADPCombined sources
Nucleotide bindingi337 – 34610NADPCombined sources
Nucleotide bindingi394 – 3974NADPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciAPER272557:GJD6-505-MONOMER.
BRENDAi1.1.1.42. 171.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP]Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:APE_0689.1Imported
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)Imported
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi6 ↔ 84Combined sources

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0689.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TYOX-ray2.15A/B1-432[»]
1V94X-ray2.28A/B1-432[»]
1XGVX-ray2.20A/B1-432[»]
1XKDX-ray2.30A/B1-432[»]
ProteinModelPortaliQ9YE81.
SMRiQ9YE81. Positions 3-432.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YE81.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 414381Iso_dhInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01164. Archaea.
COG0538. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OMAiWWELLAG.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YE81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPPCTTEE LSPPPGGSLV EYSGGSLRVP DNPVVAFIRG DGVGPEVVES
60 70 80 90 100
ALKVVDAAVK KVYGGSRRIV WWELLAGHLA REKCGELLPK ATLEGIRLAR
110 120 130 140 150
VALKGPLETP VGTGYRSLNV AIRQALDLYA NIRPVRYYGQ PAPHKYADRV
160 170 180 190 200
DMVIFRENTE DVYAGIEWPH DSPEAARIRR FLAEEFGISI REDAGIGVKP
210 220 230 240 250
ISRFATRRLM ERALEWALRN GNTVVTIMHK GNIMKYTEGA FMRWAYEVAL
260 270 280 290 300
EKFREHVVTE QEVQEKYGGV RPEGKILVND RIADNMLQQI ITRPWDYQVI
310 320 330 340 350
VAPNLNGDYI SDAASALVGG IGMAAGMNMG DGIAVAEPVH GTAPKYAGKD
360 370 380 390 400
LINPSAEILS ASLLIGEFMG WREVKSIVEY AIRKAVQSKK VTQDLARHMP
410 420 430
GVQPLRTSEY TETLIAYIDE ADLNEVLAGK RG
Length:432
Mass (Da):47,566
Last modified:November 14, 2006 - v2
Checksum:iCD2EF87B2384B33A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79665.2.
PIRiA72658.

Genome annotation databases

EnsemblBacteriaiBAA79665; BAA79665; APE_0689.1.
KEGGiape:APE_0689.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79665.2.
PIRiA72658.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TYOX-ray2.15A/B1-432[»]
1V94X-ray2.28A/B1-432[»]
1XGVX-ray2.20A/B1-432[»]
1XKDX-ray2.30A/B1-432[»]
ProteinModelPortaliQ9YE81.
SMRiQ9YE81. Positions 3-432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_0689.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA79665; BAA79665; APE_0689.1.
KEGGiape:APE_0689.1.

Phylogenomic databases

eggNOGiarCOG01164. Archaea.
COG0538. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OMAiWWELLAG.

Enzyme and pathway databases

BioCyciAPER272557:GJD6-505-MONOMER.
BRENDAi1.1.1.42. 171.

Miscellaneous databases

EvolutionaryTraceiQ9YE81.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9YE81_AERPE
AccessioniPrimary (citable) accession number: Q9YE81
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.