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Protein

tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase

Gene

taw3

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAPER272557:GJD6-592-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseUniRule annotation (EC:2.1.1.282UniRule annotation)
Alternative name(s):
tRNA wyosine derivatives biosynthesis protein Taw3UniRule annotation
Gene namesi
Name:taw3UniRule annotation
Ordered Locus Names:APE_0816
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferasePRO_0000157091Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0816.

Structurei

Secondary structure

1
188
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 213Combined sources
Helixi22 – 298Combined sources
Beta strandi34 – 407Combined sources
Beta strandi43 – 508Combined sources
Beta strandi60 – 667Combined sources
Helixi70 – 778Combined sources
Beta strandi82 – 898Combined sources
Beta strandi92 – 998Combined sources
Helixi100 – 11213Combined sources
Beta strandi117 – 1237Combined sources
Beta strandi129 – 1346Combined sources
Beta strandi138 – 1458Combined sources
Helixi153 – 18331Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DVKX-ray1.80A1-188[»]
ProteinModelPortaliQ9YDV3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YDV3.

Family & Domainsi

Sequence similaritiesi

Belongs to the TYW3 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04156. Archaea.
COG1590. LUCA.
KOiK15450.
OMAiGFKYTTF.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
HAMAPiMF_00266. TYW3_archaea. 1 hit.
InterProiIPR022908. Taw3.
IPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YDV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSIEEVLLE ERLIGYLDPG AEKVLARINR PSKIVSTSSC TGRITLIEGE
60 70 80 90 100
AHWLRNGARV AYKTHHPISR SEVERVLRRG FTNLWLKVTG PILHLRVEGW
110 120 130 140 150
QCAKSLLEAA RRNGFKHSGV ISIAEDSRLV IEIMSSQSMS VPLVMEGARI
160 170 180
VGDDALDMLI EKANTILVES RIGLDTFSRE VEELVECF
Length:188
Mass (Da):20,994
Last modified:November 1, 1999 - v1
Checksum:i2574AC83FEE9FC1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79794.1.
PIRiB72674.

Genome annotation databases

EnsemblBacteriaiBAA79794; BAA79794; APE_0816.
KEGGiape:APE_0816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79794.1.
PIRiB72674.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DVKX-ray1.80A1-188[»]
ProteinModelPortaliQ9YDV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_0816.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA79794; BAA79794; APE_0816.
KEGGiape:APE_0816.

Phylogenomic databases

eggNOGiarCOG04156. Archaea.
COG1590. LUCA.
KOiK15450.
OMAiGFKYTTF.

Enzyme and pathway databases

BioCyciAPER272557:GJD6-592-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9YDV3.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
HAMAPiMF_00266. TYW3_archaea. 1 hit.
InterProiIPR022908. Taw3.
IPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTYW3_AERPE
AccessioniPrimary (citable) accession number: Q9YDV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 11, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.