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Protein

tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase

Gene

taw3

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseUniRule annotation (EC:2.1.1.282UniRule annotation)
Alternative name(s):
tRNA wyosine derivatives biosynthesis protein Taw3UniRule annotation
Gene namesi
Name:taw3UniRule annotation
Ordered Locus Names:APE_0816
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001570911 – 188tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseAdd BLAST188

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0816.

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi19 – 21Combined sources3
Helixi22 – 29Combined sources8
Beta strandi34 – 40Combined sources7
Beta strandi43 – 50Combined sources8
Beta strandi60 – 66Combined sources7
Helixi70 – 77Combined sources8
Beta strandi82 – 89Combined sources8
Beta strandi92 – 99Combined sources8
Helixi100 – 112Combined sources13
Beta strandi117 – 123Combined sources7
Beta strandi129 – 134Combined sources6
Beta strandi138 – 145Combined sources8
Helixi153 – 183Combined sources31

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DVKX-ray1.80A1-188[»]
ProteinModelPortaliQ9YDV3.
SMRiQ9YDV3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YDV3.

Family & Domainsi

Sequence similaritiesi

Belongs to the TYW3 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04156. Archaea.
COG1590. LUCA.
KOiK15450.
OMAiGFKYTTF.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
HAMAPiMF_00266. TYW3_archaea. 1 hit.
InterProiIPR022908. Taw3.
IPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YDV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSIEEVLLE ERLIGYLDPG AEKVLARINR PSKIVSTSSC TGRITLIEGE
60 70 80 90 100
AHWLRNGARV AYKTHHPISR SEVERVLRRG FTNLWLKVTG PILHLRVEGW
110 120 130 140 150
QCAKSLLEAA RRNGFKHSGV ISIAEDSRLV IEIMSSQSMS VPLVMEGARI
160 170 180
VGDDALDMLI EKANTILVES RIGLDTFSRE VEELVECF
Length:188
Mass (Da):20,994
Last modified:November 1, 1999 - v1
Checksum:i2574AC83FEE9FC1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79794.1.
PIRiB72674.

Genome annotation databases

EnsemblBacteriaiBAA79794; BAA79794; APE_0816.
KEGGiape:APE_0816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79794.1.
PIRiB72674.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DVKX-ray1.80A1-188[»]
ProteinModelPortaliQ9YDV3.
SMRiQ9YDV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_0816.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA79794; BAA79794; APE_0816.
KEGGiape:APE_0816.

Phylogenomic databases

eggNOGiarCOG04156. Archaea.
COG1590. LUCA.
KOiK15450.
OMAiGFKYTTF.

Miscellaneous databases

EvolutionaryTraceiQ9YDV3.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
HAMAPiMF_00266. TYW3_archaea. 1 hit.
InterProiIPR022908. Taw3.
IPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTYW3_AERPE
AccessioniPrimary (citable) accession number: Q9YDV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.