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Protein

Voltage-gated potassium channel

Gene

APE_0955

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciAPER272557:GJD6-695-MONOMER.

Protein family/group databases

TCDBi1.A.1.17.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel
Alternative name(s):
KvAP
Gene namesi
Ordered Locus Names:APE_0955
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicAdd
BLAST
Transmembranei39 – 6325Helical; Name=Segment S1Add
BLAST
Topological domaini64 – 674ExtracellularSequence analysis
Transmembranei68 – 9225Helical; Name=Segment S2Add
BLAST
Topological domaini93 – 964Cytoplasmic
Intramembranei97 – 1059Helical; Name=Segment S3A
Topological domaini106 – 1083ExtracellularSequence analysis
Transmembranei109 – 12517Helical; Voltage-sensor; Name=Segment S3BAdd
BLAST
Topological domaini126 – 1283Cytoplasmic
Transmembranei129 – 14517Helical; Voltage-sensor; Name=Segment S4Add
BLAST
Topological domaini146 – 15914CytoplasmicAdd
BLAST
Transmembranei160 – 18425Helical; Name=Segment S5Add
BLAST
Topological domaini185 – 19511ExtracellularSequence analysisAdd
BLAST
Intramembranei196 – 20813Pore-formingSequence analysisAdd
BLAST
Topological domaini209 – 22113ExtracellularSequence analysisAdd
BLAST
Transmembranei222 – 25332Helical; Name=Segment S6Add
BLAST
Topological domaini254 – 29542CytoplasmicAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Voltage-gated potassium channelPRO_0000054097Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-29648N.
STRINGi272557.APE_0955.

Structurei

Secondary structure

1
295
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni32 – 343Combined sources
Helixi38 – 6023Combined sources
Helixi66 – 9227Combined sources
Turni96 – 1027Combined sources
Helixi104 – 1063Combined sources
Helixi108 – 1103Combined sources
Helixi113 – 12513Combined sources
Helixi129 – 16133Combined sources
Beta strandi186 – 1883Combined sources
Helixi196 – 20712Combined sources
Helixi220 – 25132Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ORQX-ray3.20C31-253[»]
1ORSX-ray1.90C33-161[»]
2A0LX-ray3.90A/B20-259[»]
2KYHNMR-A18-160[»]
ProteinModelPortaliQ9YDF8.
SMRiQ9YDF8. Positions 37-250.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YDF8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi209 – 2146Selectivity filter

Domaini

Contains a central ion-conduction pore surrounded by four voltage sensors which form the voltage-sensor paddles that move in response to membrane voltage changes through the fluid membrane interior, each voltage-sensor carrying their four positive charges across the membrane. It is thought that the S4 arginine residues move through the membrane's electric field to open the pore.

Sequence similaritiesi

Belongs to the potassium channel family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG01964. Archaea.
COG1226. LUCA.
KOiK10716.
OMAiHEKINTV.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YDF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVERWVFPG CSVMARFRRG LSDLGGRVRN IGDVMEHPLV ELGVSYAALL
60 70 80 90 100
SVIVVVVEYT MQLSGEYLVR LYLVDLILVI ILWADYAYRA YKSGDPAGYV
110 120 130 140 150
KKTLYEIPAL VPAGLLALIE GHLAGLGLFR LVRLLRFLRI LLIISRGSKF
160 170 180 190 200
LSAIADAADK IRFYHLFGAV MLTVLYGAFA IYIVEYPDPN SSIKSVFDAL
210 220 230 240 250
WWAVVTATTV GYGDVVPATP IGKVIGIAVM LTGISALTLL IGTVSNMFQK
260 270 280 290
ILVGEPEPSC SPAKLAEMVS SMSEEEFEEF VRTLKNLRRL ENSMK
Length:295
Mass (Da):32,535
Last modified:November 1, 1999 - v1
Checksum:i1EC8CE1E39E24D0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79939.1.
PIRiC72692.

Genome annotation databases

EnsemblBacteriaiBAA79939; BAA79939; APE_0955.
KEGGiape:APE_0955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA79939.1.
PIRiC72692.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ORQX-ray3.20C31-253[»]
1ORSX-ray1.90C33-161[»]
2A0LX-ray3.90A/B20-259[»]
2KYHNMR-A18-160[»]
ProteinModelPortaliQ9YDF8.
SMRiQ9YDF8. Positions 37-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29648N.
STRINGi272557.APE_0955.

Protein family/group databases

TCDBi1.A.1.17.1. the voltage-gated ion channel (vic) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA79939; BAA79939; APE_0955.
KEGGiape:APE_0955.

Phylogenomic databases

eggNOGiarCOG01964. Archaea.
COG1226. LUCA.
KOiK10716.
OMAiHEKINTV.

Enzyme and pathway databases

BioCyciAPER272557:GJD6-695-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9YDF8.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKVAP_AERPE
AccessioniPrimary (citable) accession number: Q9YDF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.