Reviewed, UniProtKB/Swiss-Prot Q9YDD5 (KCY_AERPE)

Names and origin

Protein names

Recommended name:
    Cytidylate kinase
      Short name=CK
    EC=2.7.4.14
Alternative name(s):
    Cytidine monophosphate kinase
      Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	APE_0978.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00239
Subcellular location	Cytoplasm By similarity HAMAP MF_00239.
Sequence similarities	Belongs to the cytidylate kinase family. Type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activity Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Cytidylate kinase HAMAP MF_00239		PRO_0000132008
Regions
	Nucleotide binding	4 – 12	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9YDD5-1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 5AF61B66CEB16F0E	FASTA	172	19,674
	10 20 30 40 50 60 MISGPPGSGK STYAKRLAED LGLSYYSTGT IFRSIARERG LSLAEMSRLA EEDPRIDLEI 70 80 90 100 110 120 DRRTLDVASR GGVVIDSHLA AWLLRDKAQY LVLVKAPVWV RVRRIARRDG VPLRRALAET 130 140 150 160 170 VEREWSQRLR FKRYYGIDVS DTTIFHLTVD TSMYSVEDTY RLILEGARRR GL

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA79962.2.
PIR	B72695.
RefSeq	NP_147642.2.
3D structure databases
SMR	Q9YDD5. Positions 1-167.
ModBase	Search...
Genome annotation databases
GeneID	1445048.
GenomeReviews	Gene locus APE_0978.1 in contig BA000002_GR.
KEGG	ape:APE_0978.1.
NMPDR	fig|272557.1.peg.750.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG578180.
Enzyme and pathway databases
BioCyc	APER272557:APE0978-MONOMER.
BRENDA	2.7.4.14. 256344.
Family and domain databases
HAMAP	MF_00239. Cytidyl_kinase_type2. [Tree]
InterPro	IPR000850. Adenylate_kin. IPR011892. Cyt_kin_arch. IPR000623. Shik_kinase. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF01202. SKI. 1 hit. [Graphical view]
TIGRFAMs	TIGR02173. cyt_kin_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_AERPE

Accession

Primary (citable) accession number: Q9YDD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 26, 2007
Last modified:	February 9, 2010
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)