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Protein

Riboflavin synthase

Gene

ribC

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribC)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Gene namesi
Name:ribC
Ordered Locus Names:APE_0988
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001348581 – 155Riboflavin synthaseAdd BLAST155

Proteomic databases

PRIDEiQ9YDC5

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_0988

Structurei

3D structure databases

ProteinModelPortaliQ9YDC5
SMRiQ9YDC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRL synthase family.Curated

Phylogenomic databases

eggNOGiarCOG01322 Archaea
COG1731 LUCA
HOGENOMiHOG000227234
KOiK00793
OMAiLMTNTHI
OrthoDBiPOG093Z0DB2

Family and domain databases

CDDicd09210 Riboflavin_synthase_archaeal, 1 hit
Gene3Di3.40.50.960, 1 hit
InterProiView protein in InterPro
IPR002180 LS/RS
IPR036467 LS/RS_sf
IPR006399 Ribfl_synth_arc
PfamiView protein in Pfam
PF00885 DMRL_synthase, 1 hit
PIRSFiPIRSF015750 Ribfl_synth_arc, 1 hit
SUPFAMiSSF52121 SSF52121, 1 hit
TIGRFAMsiTIGR01506 ribC_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YDC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKCVGVADT TFARVDMGSV AEEVLRRRLP GYRIVRHTVP GIKDLPGAAK
60 70 80 90 100
RILSMGCEGV ITLGWVGRRE ADKLSYLAAS VGLIMVEVLT GKIVIDVTVH
110 120 130 140 150
EDEAEAPEEL AAIAVDRARK HAENLAALIR EGPEALVKHA GMGLRQGYPD

AGPIK
Length:155
Mass (Da):16,576
Last modified:November 1, 1999 - v1
Checksum:i644B7A1BD313A4F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA79972.1
PIRiD72696

Genome annotation databases

EnsemblBacteriaiBAA79972; BAA79972; APE_0988
KEGGiape:APE_0988
PATRICifig|272557.25.peg.715

Similar proteinsi

Entry informationi

Entry nameiRISC_AERPE
AccessioniPrimary (citable) accession number: Q9YDC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health