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Q9YD97

- SYL_AERPE

UniProt

Q9YD97 - SYL_AERPE

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei640 – 6401ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAPER272557:GJD6-737-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:APE_1015
    OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
    Taxonomic identifieri272557 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
    ProteomesiUP000002518: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 959959Leucine--tRNA ligasePRO_0000152127Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272557.APE_1015.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9YD97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 4911"HIGH" regionAdd
    BLAST
    Motifi637 – 6415"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiFDENVAN.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9YD97-1 [UniParc]FASTAAdd to Basket

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    MERLKAVEEK WQERWREARL FEADPQPGRR KFFITFPYPY VNAYPHLGSA    50
    FTILRVDIMA RYKRMRGYNV LFPQGWHATG GPIVSSALRV REGDPRIIKT 100
    LRDMGIPEED IPRFRDPRYW VEFFTKAWRR DLERYGMSID WRREFYTTSL 150
    NPAYSRFIEW QYLKLREKGF VGKGRHPVVW CPKEQKVVGD HDRPDEYAGI 200
    SPQEAVIIKF RGRDGLVYPA LTYRPETVFG VTNLWVHPDA TYLVAEVDGE 250
    ERWIIGEQAA RELADQGHRV VILERIEGRR LLGRIVVNPA DGREVPVLPA 300
    SFVRPDLGTG VVMSVPAHAP YDYVALMELK RRPETLREYG LEPGVVESLE 350
    PIQLIAVPRA EGLLVVEEVR RRGVESQMDR EKLDEATREV YAREFYEGIM 400
    LETTGRFSGL KVAEAKEKVV EWLEERGAAL RIYTLPQEVY CRCGARTHVK 450
    IVEDQWFLLY SKPEWKALAR EAVARMEFLP GHVRRDFEAI IEALRDWAFT 500
    HKGELGTPLP WDREWVIESL SDSTIYMAYY TIAKYTQHPE KYGVEPEMLT 550
    PEVFDYVFLG AGDPGEVSRR SGIPQGLLEE MRREFLYWYP LDMRISGKDL 600
    IPNHLVFFIF HHTAIFPREL WPRAIGVNGW VLVAGEKMSK SKGNFILLRQ 650
    ALDWWGADAT RWAEVLAGAD SGLDDANFEP SVADSAVSLL SQWLDFVREN 700
    YGRPARREER WVDRWFESRL NSTIARVTRL MEEANFKTAL VEAWYKLQES 750
    YRWYLRRSGG EPREDLLRRF IEVQTLLIAP FAPHTAEEAW EAMGREGFAS 800
    TASWPEPDES KISPEVEAAE ETVQAVLEDA REVLSLIGGA DTLVVTVAAE 850
    WKYRAVEAVR RARERGASMK EALREAFKVE GVDKREAARL VQQLSRAPEV 900
    LRRAAPRSVE LEALRDAAQL LQEELGVKVV VETEEDGGSP RRANALPGRP 950
    ALYAEKRGG 959
    Length:959
    Mass (Da):110,519
    Last modified:November 1, 1999 - v1
    Checksum:i985CB5168728F7AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA80000.1.
    PIRiH72699.
    RefSeqiNP_147669.1. NC_000854.2.

    Genome annotation databases

    EnsemblBacteriaiBAA80000; BAA80000; APE_1015.
    GeneIDi1445074.
    KEGGiape:APE_1015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA80000.1 .
    PIRi H72699.
    RefSeqi NP_147669.1. NC_000854.2.

    3D structure databases

    ProteinModelPortali Q9YD97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272557.APE_1015.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA80000 ; BAA80000 ; APE_1015 .
    GeneIDi 1445074.
    KEGGi ape:APE_1015.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi FDENVAN.

    Enzyme and pathway databases

    BioCyci APER272557:GJD6-737-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

    Entry informationi

    Entry nameiSYL_AERPE
    AccessioniPrimary (citable) accession number: Q9YD97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3