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Q9YD97

- SYL_AERPE

UniProt

Q9YD97 - SYL_AERPE

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Protein
Leucine--tRNA ligase
Gene
leuS, APE_1015
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei640 – 6401ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-737-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:APE_1015
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Leucine--tRNA ligaseUniRule annotation
PRO_0000152127Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_1015.

Structurei

3D structure databases

ProteinModelPortaliQ9YD97.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 4911"HIGH" regionUniRule annotation
Add
BLAST
Motifi637 – 6415"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiFDENVAN.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YD97-1 [UniParc]FASTAAdd to Basket

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MERLKAVEEK WQERWREARL FEADPQPGRR KFFITFPYPY VNAYPHLGSA    50
FTILRVDIMA RYKRMRGYNV LFPQGWHATG GPIVSSALRV REGDPRIIKT 100
LRDMGIPEED IPRFRDPRYW VEFFTKAWRR DLERYGMSID WRREFYTTSL 150
NPAYSRFIEW QYLKLREKGF VGKGRHPVVW CPKEQKVVGD HDRPDEYAGI 200
SPQEAVIIKF RGRDGLVYPA LTYRPETVFG VTNLWVHPDA TYLVAEVDGE 250
ERWIIGEQAA RELADQGHRV VILERIEGRR LLGRIVVNPA DGREVPVLPA 300
SFVRPDLGTG VVMSVPAHAP YDYVALMELK RRPETLREYG LEPGVVESLE 350
PIQLIAVPRA EGLLVVEEVR RRGVESQMDR EKLDEATREV YAREFYEGIM 400
LETTGRFSGL KVAEAKEKVV EWLEERGAAL RIYTLPQEVY CRCGARTHVK 450
IVEDQWFLLY SKPEWKALAR EAVARMEFLP GHVRRDFEAI IEALRDWAFT 500
HKGELGTPLP WDREWVIESL SDSTIYMAYY TIAKYTQHPE KYGVEPEMLT 550
PEVFDYVFLG AGDPGEVSRR SGIPQGLLEE MRREFLYWYP LDMRISGKDL 600
IPNHLVFFIF HHTAIFPREL WPRAIGVNGW VLVAGEKMSK SKGNFILLRQ 650
ALDWWGADAT RWAEVLAGAD SGLDDANFEP SVADSAVSLL SQWLDFVREN 700
YGRPARREER WVDRWFESRL NSTIARVTRL MEEANFKTAL VEAWYKLQES 750
YRWYLRRSGG EPREDLLRRF IEVQTLLIAP FAPHTAEEAW EAMGREGFAS 800
TASWPEPDES KISPEVEAAE ETVQAVLEDA REVLSLIGGA DTLVVTVAAE 850
WKYRAVEAVR RARERGASMK EALREAFKVE GVDKREAARL VQQLSRAPEV 900
LRRAAPRSVE LEALRDAAQL LQEELGVKVV VETEEDGGSP RRANALPGRP 950
ALYAEKRGG 959
Length:959
Mass (Da):110,519
Last modified:November 1, 1999 - v1
Checksum:i985CB5168728F7AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80000.1.
PIRiH72699.
RefSeqiNP_147669.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80000; BAA80000; APE_1015.
GeneIDi1445074.
KEGGiape:APE_1015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80000.1 .
PIRi H72699.
RefSeqi NP_147669.1. NC_000854.2.

3D structure databases

ProteinModelPortali Q9YD97.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272557.APE_1015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA80000 ; BAA80000 ; APE_1015 .
GeneIDi 1445074.
KEGGi ape:APE_1015.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi FDENVAN.

Enzyme and pathway databases

BioCyci APER272557:GJD6-737-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiSYL_AERPE
AccessioniPrimary (citable) accession number: Q9YD97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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