Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei640 – 6401ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-737-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:APE_1015
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Leucine--tRNA ligasePRO_0000152127Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_1015.

Structurei

3D structure databases

ProteinModelPortaliQ9YD97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 4911"HIGH" regionAdd
BLAST
Motifi637 – 6415"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiAPIAPHW.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YD97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLKAVEEK WQERWREARL FEADPQPGRR KFFITFPYPY VNAYPHLGSA
60 70 80 90 100
FTILRVDIMA RYKRMRGYNV LFPQGWHATG GPIVSSALRV REGDPRIIKT
110 120 130 140 150
LRDMGIPEED IPRFRDPRYW VEFFTKAWRR DLERYGMSID WRREFYTTSL
160 170 180 190 200
NPAYSRFIEW QYLKLREKGF VGKGRHPVVW CPKEQKVVGD HDRPDEYAGI
210 220 230 240 250
SPQEAVIIKF RGRDGLVYPA LTYRPETVFG VTNLWVHPDA TYLVAEVDGE
260 270 280 290 300
ERWIIGEQAA RELADQGHRV VILERIEGRR LLGRIVVNPA DGREVPVLPA
310 320 330 340 350
SFVRPDLGTG VVMSVPAHAP YDYVALMELK RRPETLREYG LEPGVVESLE
360 370 380 390 400
PIQLIAVPRA EGLLVVEEVR RRGVESQMDR EKLDEATREV YAREFYEGIM
410 420 430 440 450
LETTGRFSGL KVAEAKEKVV EWLEERGAAL RIYTLPQEVY CRCGARTHVK
460 470 480 490 500
IVEDQWFLLY SKPEWKALAR EAVARMEFLP GHVRRDFEAI IEALRDWAFT
510 520 530 540 550
HKGELGTPLP WDREWVIESL SDSTIYMAYY TIAKYTQHPE KYGVEPEMLT
560 570 580 590 600
PEVFDYVFLG AGDPGEVSRR SGIPQGLLEE MRREFLYWYP LDMRISGKDL
610 620 630 640 650
IPNHLVFFIF HHTAIFPREL WPRAIGVNGW VLVAGEKMSK SKGNFILLRQ
660 670 680 690 700
ALDWWGADAT RWAEVLAGAD SGLDDANFEP SVADSAVSLL SQWLDFVREN
710 720 730 740 750
YGRPARREER WVDRWFESRL NSTIARVTRL MEEANFKTAL VEAWYKLQES
760 770 780 790 800
YRWYLRRSGG EPREDLLRRF IEVQTLLIAP FAPHTAEEAW EAMGREGFAS
810 820 830 840 850
TASWPEPDES KISPEVEAAE ETVQAVLEDA REVLSLIGGA DTLVVTVAAE
860 870 880 890 900
WKYRAVEAVR RARERGASMK EALREAFKVE GVDKREAARL VQQLSRAPEV
910 920 930 940 950
LRRAAPRSVE LEALRDAAQL LQEELGVKVV VETEEDGGSP RRANALPGRP

ALYAEKRGG
Length:959
Mass (Da):110,519
Last modified:November 1, 1999 - v1
Checksum:i985CB5168728F7AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80000.1.
PIRiH72699.
RefSeqiNP_147669.1. NC_000854.2.
WP_010866133.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80000; BAA80000; APE_1015.
GeneIDi1445074.
KEGGiape:APE_1015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80000.1.
PIRiH72699.
RefSeqiNP_147669.1. NC_000854.2.
WP_010866133.1. NC_000854.2.

3D structure databases

ProteinModelPortaliQ9YD97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_1015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA80000; BAA80000; APE_1015.
GeneIDi1445074.
KEGGiape:APE_1015.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiAPIAPHW.

Enzyme and pathway databases

BioCyciAPER272557:GJD6-737-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiSYL_AERPE
AccessioniPrimary (citable) accession number: Q9YD97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.