Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei640ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:APE_1015
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521271 – 959Leucine--tRNA ligaseAdd BLAST959

Proteomic databases

PRIDEiQ9YD97

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_1015

Structurei

3D structure databases

ProteinModelPortaliQ9YD97
SMRiQ9YD97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi39 – 49"HIGH" regionAdd BLAST11
Motifi637 – 641"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YD97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLKAVEEK WQERWREARL FEADPQPGRR KFFITFPYPY VNAYPHLGSA
60 70 80 90 100
FTILRVDIMA RYKRMRGYNV LFPQGWHATG GPIVSSALRV REGDPRIIKT
110 120 130 140 150
LRDMGIPEED IPRFRDPRYW VEFFTKAWRR DLERYGMSID WRREFYTTSL
160 170 180 190 200
NPAYSRFIEW QYLKLREKGF VGKGRHPVVW CPKEQKVVGD HDRPDEYAGI
210 220 230 240 250
SPQEAVIIKF RGRDGLVYPA LTYRPETVFG VTNLWVHPDA TYLVAEVDGE
260 270 280 290 300
ERWIIGEQAA RELADQGHRV VILERIEGRR LLGRIVVNPA DGREVPVLPA
310 320 330 340 350
SFVRPDLGTG VVMSVPAHAP YDYVALMELK RRPETLREYG LEPGVVESLE
360 370 380 390 400
PIQLIAVPRA EGLLVVEEVR RRGVESQMDR EKLDEATREV YAREFYEGIM
410 420 430 440 450
LETTGRFSGL KVAEAKEKVV EWLEERGAAL RIYTLPQEVY CRCGARTHVK
460 470 480 490 500
IVEDQWFLLY SKPEWKALAR EAVARMEFLP GHVRRDFEAI IEALRDWAFT
510 520 530 540 550
HKGELGTPLP WDREWVIESL SDSTIYMAYY TIAKYTQHPE KYGVEPEMLT
560 570 580 590 600
PEVFDYVFLG AGDPGEVSRR SGIPQGLLEE MRREFLYWYP LDMRISGKDL
610 620 630 640 650
IPNHLVFFIF HHTAIFPREL WPRAIGVNGW VLVAGEKMSK SKGNFILLRQ
660 670 680 690 700
ALDWWGADAT RWAEVLAGAD SGLDDANFEP SVADSAVSLL SQWLDFVREN
710 720 730 740 750
YGRPARREER WVDRWFESRL NSTIARVTRL MEEANFKTAL VEAWYKLQES
760 770 780 790 800
YRWYLRRSGG EPREDLLRRF IEVQTLLIAP FAPHTAEEAW EAMGREGFAS
810 820 830 840 850
TASWPEPDES KISPEVEAAE ETVQAVLEDA REVLSLIGGA DTLVVTVAAE
860 870 880 890 900
WKYRAVEAVR RARERGASMK EALREAFKVE GVDKREAARL VQQLSRAPEV
910 920 930 940 950
LRRAAPRSVE LEALRDAAQL LQEELGVKVV VETEEDGGSP RRANALPGRP

ALYAEKRGG
Length:959
Mass (Da):110,519
Last modified:November 1, 1999 - v1
Checksum:i985CB5168728F7AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA80000.1
PIRiH72699

Genome annotation databases

EnsemblBacteriaiBAA80000; BAA80000; APE_1015
KEGGiape:APE_1015
PATRICifig|272557.25.peg.731

Similar proteinsi

Entry informationi

Entry nameiSYL_AERPE
AccessioniPrimary (citable) accession number: Q9YD97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health