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Q9YD97 (SYL_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:APE_1015
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length959 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 959959Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152127

Regions

Motif39 – 4911"HIGH" region HAMAP-Rule MF_00049
Motif637 – 6415"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6401ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9YD97 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 985CB5168728F7AB

FASTA959110,519
        10         20         30         40         50         60 
MERLKAVEEK WQERWREARL FEADPQPGRR KFFITFPYPY VNAYPHLGSA FTILRVDIMA 

        70         80         90        100        110        120 
RYKRMRGYNV LFPQGWHATG GPIVSSALRV REGDPRIIKT LRDMGIPEED IPRFRDPRYW 

       130        140        150        160        170        180 
VEFFTKAWRR DLERYGMSID WRREFYTTSL NPAYSRFIEW QYLKLREKGF VGKGRHPVVW 

       190        200        210        220        230        240 
CPKEQKVVGD HDRPDEYAGI SPQEAVIIKF RGRDGLVYPA LTYRPETVFG VTNLWVHPDA 

       250        260        270        280        290        300 
TYLVAEVDGE ERWIIGEQAA RELADQGHRV VILERIEGRR LLGRIVVNPA DGREVPVLPA 

       310        320        330        340        350        360 
SFVRPDLGTG VVMSVPAHAP YDYVALMELK RRPETLREYG LEPGVVESLE PIQLIAVPRA 

       370        380        390        400        410        420 
EGLLVVEEVR RRGVESQMDR EKLDEATREV YAREFYEGIM LETTGRFSGL KVAEAKEKVV 

       430        440        450        460        470        480 
EWLEERGAAL RIYTLPQEVY CRCGARTHVK IVEDQWFLLY SKPEWKALAR EAVARMEFLP 

       490        500        510        520        530        540 
GHVRRDFEAI IEALRDWAFT HKGELGTPLP WDREWVIESL SDSTIYMAYY TIAKYTQHPE 

       550        560        570        580        590        600 
KYGVEPEMLT PEVFDYVFLG AGDPGEVSRR SGIPQGLLEE MRREFLYWYP LDMRISGKDL 

       610        620        630        640        650        660 
IPNHLVFFIF HHTAIFPREL WPRAIGVNGW VLVAGEKMSK SKGNFILLRQ ALDWWGADAT 

       670        680        690        700        710        720 
RWAEVLAGAD SGLDDANFEP SVADSAVSLL SQWLDFVREN YGRPARREER WVDRWFESRL 

       730        740        750        760        770        780 
NSTIARVTRL MEEANFKTAL VEAWYKLQES YRWYLRRSGG EPREDLLRRF IEVQTLLIAP 

       790        800        810        820        830        840 
FAPHTAEEAW EAMGREGFAS TASWPEPDES KISPEVEAAE ETVQAVLEDA REVLSLIGGA 

       850        860        870        880        890        900 
DTLVVTVAAE WKYRAVEAVR RARERGASMK EALREAFKVE GVDKREAARL VQQLSRAPEV 

       910        920        930        940        950 
LRRAAPRSVE LEALRDAAQL LQEELGVKVV VETEEDGGSP RRANALPGRP ALYAEKRGG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA80000.1.
PIRH72699.
RefSeqNP_147669.1. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YD97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_1015.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA80000; BAA80000; APE_1015.
GeneID1445074.
KEGGape:APE_1015.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000216620.
KOK01869.
OMAALANMTI.
ProtClustDBPRK12300.

Enzyme and pathway databases

BioCycAPER272557:GJD6-737-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_A. Leu_tRNA_synth_A.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_AERPE
AccessionPrimary (citable) accession number: Q9YD97
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries