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Q9YD40

- Q9YD40_AERPE

UniProt

Q9YD40 - Q9YD40_AERPE

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Protein

Succinyl-CoA ligase [ADP-forming] subunit alpha

Gene

sucD

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei249 – 2491Tele-phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP citrate synthase activity Source: InterPro
  3. cofactor binding Source: InterPro
  4. succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)
Gene namesi
Name:sucDImported
Ordered Locus Names:APE_1072.1Imported
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)Imported
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_1072.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YV2X-ray2.20A1-292[»]
ProteinModelPortaliQ9YD40.
SMRiQ9YD40. Positions 4-290.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YD40.

Family & Domainsi

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0074.
HOGENOMiHOG000239685.
KOiK01902.
OMAiFEQDPQT.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YD40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVLVDSETR VLVQGITGRE GSFHAKAMLE YGTKVVAGVT PGKGGSEVHG
60 70 80 90 100
VPVYDSVKEA LAEHPEINTS IVFVPAPFAP DAVYEAVDAG IRLVVVITEG
110 120 130 140 150
IPVHDTMRFV NYARQKGATI IGPNCPGAIT PGQAKVGIMP GHIFKEGGVA
160 170 180 190 200
VVSRSGTLTY EISYMLTRQG IGQSTVIGIG GDPIVGLSFT EALKLFQEDP
210 220 230 240 250
QTEALVLIGE IGGDMEERAA EMIKKGEFTK PVIAYIAGRT APPEKRMGHA
260 270 280 290
GAIIMMGTGT YEGKVKALRE AGVEVAETPF EVPELVRKAL RR
Length:292
Mass (Da):30,897
Last modified:November 14, 2006 - v2
Checksum:iC6D0BFC049CE1F75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80057.2.
PIRiA72707.
RefSeqiNP_147697.2. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80057; BAA80057; APE_1072.1.
GeneIDi1445101.
KEGGiape:APE_1072.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80057.2 .
PIRi A72707.
RefSeqi NP_147697.2. NC_000854.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YV2 X-ray 2.20 A 1-292 [» ]
ProteinModelPortali Q9YD40.
SMRi Q9YD40. Positions 4-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_1072.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA80057 ; BAA80057 ; APE_1072.1 .
GeneIDi 1445101.
KEGGi ape:APE_1072.1.

Phylogenomic databases

eggNOGi COG0074.
HOGENOMi HOG000239685.
KOi K01902.
OMAi FEQDPQT.

Enzyme and pathway databases

BioCyci APER272557:GJD6-760-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9YD40.

Family and domain databases

Gene3Di 3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view ]
Pfami PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001553. SucCS_alpha. 1 hit.
PRINTSi PR01798. SCOASYNTHASE.
SMARTi SM00881. CoA_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF52210. SSF52210. 1 hit.
TIGRFAMsi TIGR01019. sucCoAalpha. 1 hit.
PROSITEi PS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1Imported.
  2. "Crystal Structure of Succinyl-CoA Synthetase Alpha Chain from Aeropyrum pernix K1."
    Niwa H., Kuramitsu S., Yokoyama S.
    Submitted (APR-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).

Entry informationi

Entry nameiQ9YD40_AERPE
AccessioniPrimary (citable) accession number: Q9YD40
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3