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Q9YD40

- Q9YD40_AERPE

UniProt

Q9YD40 - Q9YD40_AERPE

Protein

Succinyl-CoA ligase [ADP-forming] subunit alpha

Gene

sucD

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei249 – 2491Tele-phosphohistidine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP citrate synthase activity Source: InterPro
    3. cofactor binding Source: InterPro
    4. succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAPER272557:GJD6-760-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinyl-CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)
    Gene namesi
    Name:sucDImported
    Ordered Locus Names:APE_1072.1Imported
    OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)Imported
    Taxonomic identifieri272557 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
    ProteomesiUP000002518: Chromosome

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha and two beta subunits.UniRule annotation
    Heterotetramer of two alpha and two beta subunits By similarity.

    Protein-protein interaction databases

    STRINGi272557.APE_1072.1.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YV2X-ray2.20A1-292[»]
    ProteinModelPortaliQ9YD40.
    SMRiQ9YD40. Positions 4-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9YD40.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0074.
    HOGENOMiHOG000239685.
    KOiK01902.
    OMAiFEQDPQT.

    Family and domain databases

    Gene3Di3.40.50.261. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
    IPR003781. CoA-bd.
    IPR005810. CoA_lig_alpha.
    IPR005811. CoA_ligase.
    IPR016040. NAD(P)-bd_dom.
    IPR016102. Succinyl-CoA_synth-like.
    [Graphical view]
    PfamiPF02629. CoA_binding. 1 hit.
    PF00549. Ligase_CoA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
    PRINTSiPR01798. SCOASYNTHASE.
    SMARTiSM00881. CoA_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF52210. SSF52210. 1 hit.
    TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
    PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
    PS00399. SUCCINYL_COA_LIG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9YD40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLVDSETR VLVQGITGRE GSFHAKAMLE YGTKVVAGVT PGKGGSEVHG    50
    VPVYDSVKEA LAEHPEINTS IVFVPAPFAP DAVYEAVDAG IRLVVVITEG 100
    IPVHDTMRFV NYARQKGATI IGPNCPGAIT PGQAKVGIMP GHIFKEGGVA 150
    VVSRSGTLTY EISYMLTRQG IGQSTVIGIG GDPIVGLSFT EALKLFQEDP 200
    QTEALVLIGE IGGDMEERAA EMIKKGEFTK PVIAYIAGRT APPEKRMGHA 250
    GAIIMMGTGT YEGKVKALRE AGVEVAETPF EVPELVRKAL RR 292
    Length:292
    Mass (Da):30,897
    Last modified:November 14, 2006 - v2
    Checksum:iC6D0BFC049CE1F75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA80057.2.
    PIRiA72707.
    RefSeqiNP_147697.2. NC_000854.2.

    Genome annotation databases

    EnsemblBacteriaiBAA80057; BAA80057; APE_1072.1.
    GeneIDi1445101.
    KEGGiape:APE_1072.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA80057.2 .
    PIRi A72707.
    RefSeqi NP_147697.2. NC_000854.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YV2 X-ray 2.20 A 1-292 [» ]
    ProteinModelPortali Q9YD40.
    SMRi Q9YD40. Positions 4-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272557.APE_1072.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA80057 ; BAA80057 ; APE_1072.1 .
    GeneIDi 1445101.
    KEGGi ape:APE_1072.1.

    Phylogenomic databases

    eggNOGi COG0074.
    HOGENOMi HOG000239685.
    KOi K01902.
    OMAi FEQDPQT.

    Enzyme and pathway databases

    BioCyci APER272557:GJD6-760-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9YD40.

    Family and domain databases

    Gene3Di 3.40.50.261. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR017440. Cit_synth/succinyl-CoA_lig_AS.
    IPR003781. CoA-bd.
    IPR005810. CoA_lig_alpha.
    IPR005811. CoA_ligase.
    IPR016040. NAD(P)-bd_dom.
    IPR016102. Succinyl-CoA_synth-like.
    [Graphical view ]
    Pfami PF02629. CoA_binding. 1 hit.
    PF00549. Ligase_CoA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001553. SucCS_alpha. 1 hit.
    PRINTSi PR01798. SCOASYNTHASE.
    SMARTi SM00881. CoA_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52210. SSF52210. 1 hit.
    TIGRFAMsi TIGR01019. sucCoAalpha. 1 hit.
    PROSITEi PS01216. SUCCINYL_COA_LIG_1. 1 hit.
    PS00399. SUCCINYL_COA_LIG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1Imported.
    2. "Crystal Structure of Succinyl-CoA Synthetase Alpha Chain from Aeropyrum pernix K1."
      Niwa H., Kuramitsu S., Yokoyama S.
      Submitted (APR-2007) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).

    Entry informationi

    Entry nameiQ9YD40_AERPE
    AccessioniPrimary (citable) accession number: Q9YD40
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3