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Protein

Succinyl-CoA ligase [ADP-forming] subunit alpha

Gene

sucD

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei249 – 2491Tele-phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP citrate synthase activity Source: InterPro
  3. cofactor binding Source: InterPro
  4. succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)
Gene namesi
Name:sucDImported
Ordered Locus Names:APE_1072.1Imported
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)Imported
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_1072.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YV2X-ray2.20A1-292[»]
ProteinModelPortaliQ9YD40.
SMRiQ9YD40. Positions 4-290.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YD40.

Family & Domainsi

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0074.
HOGENOMiHOG000239685.
KOiK01902.
OMAiITEHIPI.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YD40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLVDSETR VLVQGITGRE GSFHAKAMLE YGTKVVAGVT PGKGGSEVHG
60 70 80 90 100
VPVYDSVKEA LAEHPEINTS IVFVPAPFAP DAVYEAVDAG IRLVVVITEG
110 120 130 140 150
IPVHDTMRFV NYARQKGATI IGPNCPGAIT PGQAKVGIMP GHIFKEGGVA
160 170 180 190 200
VVSRSGTLTY EISYMLTRQG IGQSTVIGIG GDPIVGLSFT EALKLFQEDP
210 220 230 240 250
QTEALVLIGE IGGDMEERAA EMIKKGEFTK PVIAYIAGRT APPEKRMGHA
260 270 280 290
GAIIMMGTGT YEGKVKALRE AGVEVAETPF EVPELVRKAL RR
Length:292
Mass (Da):30,897
Last modified:November 14, 2006 - v2
Checksum:iC6D0BFC049CE1F75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80057.2.
PIRiA72707.
RefSeqiNP_147697.2. NC_000854.2.
WP_010866156.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80057; BAA80057; APE_1072.1.
GeneIDi1445101.
KEGGiape:APE_1072.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80057.2.
PIRiA72707.
RefSeqiNP_147697.2. NC_000854.2.
WP_010866156.1. NC_000854.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YV2X-ray2.20A1-292[»]
ProteinModelPortaliQ9YD40.
SMRiQ9YD40. Positions 4-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_1072.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA80057; BAA80057; APE_1072.1.
GeneIDi1445101.
KEGGiape:APE_1072.1.

Phylogenomic databases

eggNOGiCOG0074.
HOGENOMiHOG000239685.
KOiK01902.
OMAiITEHIPI.

Enzyme and pathway databases

BioCyciAPER272557:GJD6-760-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9YD40.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1Imported.
  2. "Crystal Structure of Succinyl-CoA Synthetase Alpha Chain from Aeropyrum pernix K1."
    Niwa H., Kuramitsu S., Yokoyama S.
    Submitted (APR-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).

Entry informationi

Entry nameiQ9YD40_AERPE
AccessioniPrimary (citable) accession number: Q9YD40
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 14, 2006
Last modified: February 4, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.