Q9YD40 (Q9YD40_AERPE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alpha RuleBase RU000699
EC=6.2.1.5 RuleBase RU000699

Gene names

Name:	sucD EMBL BAA80057.2
Ordered Locus Names:	APE_1072.1 EMBL BAA80057.2

Organism

Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP] EMBL BAA80057.2

Taxonomic identifier

272557 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum › Aeropyrum pernix

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. RuleBase RU000699
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity. RuleBase RU000699
Sequence similarities	Belongs to the succinate/malate CoA ligase alpha subunit family. RuleBase RU000677

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000699 Nucleotide-binding
Molecular function	Ligase RuleBase RU000677 EMBL BAA80057.2
PTM	Phosphoprotein RuleBase RU000677
Technical term	3D-structure PDB 2YV2 Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP citrate synthase activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	249	1	Tele-phosphohistidine intermediate By similarity PIRSR PIRSR001553-1

Sequences

	Sequence		Length	Mass (Da)
	Q9YD40 [UniParc]. Last modified November 14, 2006. Version 2. Checksum: C6D0BFC049CE1F75	FASTA	292	30,897
	10 20 30 40 50 60 MAVLVDSETR VLVQGITGRE GSFHAKAMLE YGTKVVAGVT PGKGGSEVHG VPVYDSVKEA 70 80 90 100 110 120 LAEHPEINTS IVFVPAPFAP DAVYEAVDAG IRLVVVITEG IPVHDTMRFV NYARQKGATI 130 140 150 160 170 180 IGPNCPGAIT PGQAKVGIMP GHIFKEGGVA VVSRSGTLTY EISYMLTRQG IGQSTVIGIG 190 200 210 220 230 240 GDPIVGLSFT EALKLFQEDP QTEALVLIGE IGGDMEERAA EMIKKGEFTK PVIAYIAGRT 250 260 270 280 290 APPEKRMGHA GAIIMMGTGT YEGKVKALRE AGVEVAETPF EVPELVRKAL RR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.
[2]	"Crystal Structure of Succinyl-CoA Synthetase Alpha Chain from Aeropyrum pernix K1." Niwa H., Kuramitsu S., Yokoyama S. Submitted (APR-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000002 Genomic DNA. Translation: BAA80057.2.

PIR

A72707.

RefSeq

NP_147697.2. NC_000854.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YV2	X-ray	2.20	A	1-292	[»]

ProteinModelPortal

Q9YD40.

SMR

Q9YD40. Positions 4-290.

ModBase

Search...

Protein-protein interaction databases

STRING

272557.APE_1072.1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

BAA80057; BAA80057; APE_1072.1.

GeneID

1445101.

KEGG

ape:APE_1072.1.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG0074.

HOGENOM

HOG000239685.

KO

K01902.

OMA

KGRKKPM.

ProtClustDB

CLSK961092.

Enzyme and pathway databases

BioCyc

APER272557:GJD6-760-MONOMER.

Family and domain databases

Gene3D

3.40.50.261. 1 hit.
3.40.50.720. 1 hit.

InterPro

IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]

Pfam

PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]

PIRSF

PIRSF001553. SucCS_alpha. 1 hit.

PRINTS

PR01798. SCOASYNTHASE.

SMART

SM00881. CoA_binding. 1 hit.
[Graphical view]

SUPFAM

SSF52210. CoA_ligase. 1 hit.

TIGRFAMs

TIGR01019. sucCoAalpha. 1 hit.

PROSITE

PS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9YD40.

Entry information

Entry name

Q9YD40_AERPE

Accession

Primary (citable) accession number: Q9YD40

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 14, 2006
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)