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Q9YD18

- DNLI_AERPE

UniProt

Q9YD18 - DNLI_AERPE

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Protein

DNA ligase

Gene

lig

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.By similarity

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactori

Divalent metal cations.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei262 – 2621ATPBy similarity
Active sitei264 – 2641N6-AMP-lysine intermediateBy similarity
Binding sitei269 – 2691ATPBy similarity
Binding sitei284 – 2841ATPBy similarity
Binding sitei314 – 3141ATPBy similarity
Binding sitei354 – 3541ATPBy similarity
Binding sitei431 – 4311ATPBy similarity
Binding sitei437 – 4371ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-774-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:APE_1094.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602DNA ligasePRO_0000059600Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_1094.1.

Structurei

3D structure databases

ProteinModelPortaliQ9YD18.
SMRiQ9YD18. Positions 1-594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YD18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFKPVAEAF ASMERITSRT QLTLLLTRLF KSTPPGAIGI VVYLIQGKLG
60 70 80 90 100
PDWKGLPELG VGEKLLVKAI ALAYKATEER VERLYKSVGD LGSVAERLSR
110 120 130 140 150
EYRSRAARAV TLEAFMAGGG EALTVRRVYN TLYRIAMAQG EGSRDIKLRL
160 170 180 190 200
LAGLLADAEP VEAKYIVRFV EGRLRVGVGD ATVLDALAMA FGGGAHARPV
210 220 230 240 250
IERAYNLRAD LGYIAEVVAR EGVDALRGVK PQVGVPIRPM LAERGRDPAE
260 270 280 290 300
ILRKVGGRAV VEYKYDGERA QIHKKDGEVY IYSRRLENIT RMFPDVVEMA
310 320 330 340 350
RKGLKAGEAI VEGEIVAVDP DNYEIQPFQV LMQRKRKHDI HRVMREVPVA
360 370 380 390 400
VFLFDALYVD GEDLTSKPLP ERRRRLKEIV VETPLWRLAE SIETSDPEEL
410 420 430 440 450
WTFFLKAIEE GAEGVMVKAV HRDSVYTAGV RGWLWVKLKR DYKSEMMDTV
460 470 480 490 500
DLVVVGAFYG RGKRGGKLSS LLMAAYDPDR DVFPTVCKVA TGFTDEELDR
510 520 530 540 550
MNEMLKKHII PRKHPRVESR IEPDVWVEPA LVAEILGAEL TLSPMHTCCL
560 570 580 590 600
NTVRPGVGIS IRFPRFIRWR DDKSPEDATT THELLEMYKR QLRRVEEPAE

QV
Length:602
Mass (Da):67,748
Last modified:June 20, 2001 - v2
Checksum:iAD1DC7521FAFD814
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80079.2.
PIRiG72709.
RefSeqiNP_147713.2. NC_000854.2.
WP_010866170.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80079; BAA80079; APE_1094.1.
GeneIDi1445787.
KEGGiape:APE_1094.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80079.2 .
PIRi G72709.
RefSeqi NP_147713.2. NC_000854.2.
WP_010866170.1. NC_000854.2.

3D structure databases

ProteinModelPortali Q9YD18.
SMRi Q9YD18. Positions 1-594.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_1094.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA80079 ; BAA80079 ; APE_1094.1 .
GeneIDi 1445787.
KEGGi ape:APE_1094.1.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci APER272557:GJD6-774-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiDNLI_AERPE
AccessioniPrimary (citable) accession number: Q9YD18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3