Reviewed, UniProtKB/Swiss-Prot Q9YD08 (PPNK_AERPE)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase
      Short name=Poly(P)/ATP NAD kinase
    EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	APE_1104.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000120696

Sequences

	Sequence		Length	Mass (Da)
	Q9YD08-1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: CF435A81768025AF	FASTA	280	31,067
	10 20 30 40 50 60 MSGAVGLVVK RRSGIAEDVA RLVVKELVES GVEVLVDETV DYPSLSGFPR FSISRDPPGR 70 80 90 100 110 120 VVVVGGDGTL LRTFLRLGER ESPLFMTIKA GKKGFLLDVE RYEAVERLRD FLEGRFREVV 130 140 150 160 170 180 YPRYRVYLEG EARACMFNDT AVTANNAKMA RVHVFVDGDL AMNIDGDGVV VSTTAGSTAY 190 200 210 220 230 240 SLSGGGPIID PRLDVIVLTP LNPVQLFLRS IVVPSGSRVT VEASVYSNPL VVNIDGQYVY 250 260 270 280 ELEPGGIVDI ERCGSGVRIA RFRWWEDYYE RLYTRLLAYW

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA80089.2.
PIR	A72711.
RefSeq	NP_147717.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1445791.
GenomeReviews	Gene locus APE_1104.1 in contig BA000002_GR.
KEGG	ape:APE_1104.1.
NMPDR	fig|272557.1.peg.825.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YD08.
Enzyme and pathway databases
BRENDA	2.7.1.23. 256344.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR002504. ATP_NADK. [Graphical view]
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK_AERPE

Accession

Primary (citable) accession number: Q9YD08

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 26, 2007
Last modified:	June 16, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)