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Q9YD08 (NADK_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:APE_1104.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280NAD kinase HAMAP-Rule MF_00361
PRO_0000120696

Regions

Nucleotide binding67 – 682NAD By similarity
Nucleotide binding138 – 1392NAD By similarity
Nucleotide binding178 – 1836NAD By similarity

Sites

Active site671Proton acceptor By similarity
Binding site721NAD By similarity
Binding site1671NAD By similarity
Binding site1751NAD; via carbonyl oxygen By similarity
Binding site2371NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9YD08 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: CF435A81768025AF

FASTA28031,067
        10         20         30         40         50         60 
MSGAVGLVVK RRSGIAEDVA RLVVKELVES GVEVLVDETV DYPSLSGFPR FSISRDPPGR 

        70         80         90        100        110        120 
VVVVGGDGTL LRTFLRLGER ESPLFMTIKA GKKGFLLDVE RYEAVERLRD FLEGRFREVV 

       130        140        150        160        170        180 
YPRYRVYLEG EARACMFNDT AVTANNAKMA RVHVFVDGDL AMNIDGDGVV VSTTAGSTAY 

       190        200        210        220        230        240 
SLSGGGPIID PRLDVIVLTP LNPVQLFLRS IVVPSGSRVT VEASVYSNPL VVNIDGQYVY 

       250        260        270        280 
ELEPGGIVDI ERCGSGVRIA RFRWWEDYYE RLYTRLLAYW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA80089.2.
PIRA72711.
RefSeqNP_147717.2. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YD08.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_1104.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA80089; BAA80089; APE_1104.1.
GeneID1445791.
KEGGape:APE_1104.1.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.

Enzyme and pathway databases

BioCycAPER272557:GJD6-777-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_AERPE
AccessionPrimary (citable) accession number: Q9YD08
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 26, 2007
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families