Reviewed, UniProtKB/Swiss-Prot Q9YCX7 (GCP_AERPE)

Names and origin

Protein names

Recommended name:
    Putative O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	APE_1135

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01446
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Putative O-sialoglycoprotein endopeptidase HAMAP MF_01446		PRO_0000303630
Sites
	Metal binding	117	1	Zinc Potential
	Metal binding	121	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9YCX7-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 7974A476E4D3BFBF	FASTA	349	36,829
	10 20 30 40 50 60 MPPKRDGEVL VLGIESTAHT FGVGIVSTRP PIVRADVRRR WTPREGGILP REVAEFFSLH 70 80 90 100 110 120 AGEAVAEALG EAGVSIADVD AVAVALGPGM GPALRVGATV ARALSAKYGK PLVPVNHAVA 130 140 150 160 170 180 HVEAARFTTG LRDPVALYVA GGNTTVVSFV AGRYRTFGET LDIALGNLLD TFAREAGIAP 190 200 210 220 230 240 PYVAGGLHAV DRCAEGGGFV EGIPYVVKGQ DVSFSGILTA ALRLLKRGAR LSDVCYTLRE 250 260 270 280 290 300 VAFSSVVEVT ERCLAHTGKR QATLTGGVAA NRVLNEKMSL MAGLHGAVYR PVDVRLSGDN 310 320 330 340 GVMIALTGLA AYLHGVIIDP GEAYIRQRWR IDEVDIPWYP WLPGDPPPG

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA80120.1.
PIR	H72714.
RefSeq	NP_147734.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.003.
Genome annotation databases
GeneID	1445807.
GenomeReviews	Gene locus APE_1135 in contig BA000002_GR.
KEGG	ape:APE_1135.
NMPDR	fig|272557.1.peg.842.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YCX7.
OMA	TQRFRTD.
Enzyme and pathway databases
BRENDA	3.4.24.57. 256344.
Family and domain databases
HAMAP	MF_01446. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_AERPE

Accession

Primary (citable) accession number: Q9YCX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	November 1, 1999
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)