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Q9YCQ6

- GLMS_AERPE

UniProt

Q9YCQ6 - GLMS_AERPE

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei612 – 6121For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciAPER272557:GJD6-829-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:APE_1205.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 617616Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135422Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_1205.1.

Structurei

3D structure databases

ProteinModelPortaliQ9YCQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 222221Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini293 – 432140SIS 1UniRule annotationAdd
BLAST
Domaini466 – 607142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YCQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIIGLAFA EGNSVAGALV RGLKRLEYRG YDSMGVAVIE PPGRLVVRKA
60 70 80 90 100
AGKIGEVVRR TGVLSLRGRV GIGHTRWATH GPPNDVNAHP HTDCGGRVAV
110 120 130 140 150
VHNGVIRNYA SLRRELEARG HRLVSETDTE LVAHLIEEYL GRGYSFLEAL
160 170 180 190 200
SLLGRVLRGS YALALLHLGE PDKVYFLRYK SPLVVGLGEG VNAVASDITA
210 220 230 240 250
VLDVARDVIV LEDGEFGWIS PEGVAIYRPR GDGGFEPLPP GALEERVKRV
260 270 280 290 300
EWTPESASKA GYPHFMLKEI YEQPRALAET FEGIIEDPAL LRAAGLVAGA
310 320 330 340 350
GRLLIVGAGT SFHAGLVGHY YLSRLAGILG HPVVASEHKV YTPGVDGETV
360 370 380 390 400
VVAVSQSGET YDTLEAVREW RGRGARVIGV TNVVGSALDR EADVTLYLRA
410 420 430 440 450
GPEIGVAATK TFLAQTILLQ TLSIAAAGEA GRLTSGETRE LTGVLEGAPD
460 470 480 490 500
AARRAILASE GAAREAASLL KGAGSMYIIG RGLGGRLAME AALKVKEVSY
510 520 530 540 550
IHAEAYPAGE SKHGPIALVE PGFKVYVVAT SDSPEVMGNA IEMKARGASV
560 570 580 590 600
TVVAPSDLQL DTPEGIEVLK MPPTGGETLL DPYSLTPYFQ LLAYHLAVAR
610
GYDPDKPRNL AKTVTVE
Length:617
Mass (Da):65,471
Last modified:January 23, 2007 - v3
Checksum:i3BCD6572AFD380D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80191.2.
PIRiA72592.
RefSeqiNP_147783.2. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80191; BAA80191; APE_1205.1.
GeneIDi1445855.
KEGGiape:APE_1205.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80191.2 .
PIRi A72592.
RefSeqi NP_147783.2. NC_000854.2.

3D structure databases

ProteinModelPortali Q9YCQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_1205.1.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA80191 ; BAA80191 ; APE_1205.1 .
GeneIDi 1445855.
KEGGi ape:APE_1205.1.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.

Enzyme and pathway databases

BioCyci APER272557:GJD6-829-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiGLMS_AERPE
AccessioniPrimary (citable) accession number: Q9YCQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3