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Q9YCQ6

- GLMS_AERPE

UniProt

Q9YCQ6 - GLMS_AERPE

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, APE_1205.1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei612 – 6121For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciAPER272557:GJD6-829-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:APE_1205.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 617616Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135422Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_1205.1.

Structurei

3D structure databases

ProteinModelPortaliQ9YCQ6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 222221Glutamine amidotransferase type-2
Add
BLAST
Domaini293 – 432140SIS 1
Add
BLAST
Domaini466 – 607142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9YCQ6-1 [UniParc]FASTAAdd to Basket

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MCGIIGLAFA EGNSVAGALV RGLKRLEYRG YDSMGVAVIE PPGRLVVRKA    50
AGKIGEVVRR TGVLSLRGRV GIGHTRWATH GPPNDVNAHP HTDCGGRVAV 100
VHNGVIRNYA SLRRELEARG HRLVSETDTE LVAHLIEEYL GRGYSFLEAL 150
SLLGRVLRGS YALALLHLGE PDKVYFLRYK SPLVVGLGEG VNAVASDITA 200
VLDVARDVIV LEDGEFGWIS PEGVAIYRPR GDGGFEPLPP GALEERVKRV 250
EWTPESASKA GYPHFMLKEI YEQPRALAET FEGIIEDPAL LRAAGLVAGA 300
GRLLIVGAGT SFHAGLVGHY YLSRLAGILG HPVVASEHKV YTPGVDGETV 350
VVAVSQSGET YDTLEAVREW RGRGARVIGV TNVVGSALDR EADVTLYLRA 400
GPEIGVAATK TFLAQTILLQ TLSIAAAGEA GRLTSGETRE LTGVLEGAPD 450
AARRAILASE GAAREAASLL KGAGSMYIIG RGLGGRLAME AALKVKEVSY 500
IHAEAYPAGE SKHGPIALVE PGFKVYVVAT SDSPEVMGNA IEMKARGASV 550
TVVAPSDLQL DTPEGIEVLK MPPTGGETLL DPYSLTPYFQ LLAYHLAVAR 600
GYDPDKPRNL AKTVTVE 617
Length:617
Mass (Da):65,471
Last modified:January 23, 2007 - v3
Checksum:i3BCD6572AFD380D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80191.2.
PIRiA72592.
RefSeqiNP_147783.2. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80191; BAA80191; APE_1205.1.
GeneIDi1445855.
KEGGiape:APE_1205.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80191.2 .
PIRi A72592.
RefSeqi NP_147783.2. NC_000854.2.

3D structure databases

ProteinModelPortali Q9YCQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_1205.1.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA80191 ; BAA80191 ; APE_1205.1 .
GeneIDi 1445855.
KEGGi ape:APE_1205.1.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.

Enzyme and pathway databases

BioCyci APER272557:GJD6-829-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiGLMS_AERPE
AccessioniPrimary (citable) accession number: Q9YCQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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