Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9YC65 (DHE3_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate dehydrogenase

Short name=GDH
EC=1.4.1.3
Gene names
Name:gdhA
Ordered Locus Names:APE_1386.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutamate dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Glutamate dehydrogenase
PRO_0000182754

Regions

Nucleotide binding217 – 2237NAD Potential

Sites

Active site1051 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9YC65 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: 7C0A806BB62CA6E5

FASTA41846,171
        10         20         30         40         50         60 
MQPTDPLEEA RAQLRRAVDL LGYDDYVYEV LANPDRVLQV RVTIKMDDGT VKTFLGWRSQ 

        70         80         90        100        110        120 
HNSALGPYKG GVRYHPNVTM NEVIALSMWM TWKNSLAGLP YGGGKGGVRV NPKILSPREL 

       130        140        150        160        170        180 
ELLSRKYFES ISDIVGVDQD IPAPDVYTDP QVMSWFLDEY NRVKRGQFFG VVTGKPVELG 

       190        200        210        220        230        240 
GLNARIVSTG YGVAVSTRVA AEKFLGGLEG RTVAVQGYGN VGYYAAKFLA EMGAKIVAVS 

       250        260        270        280        290        300 
DSRGGIYDPE GIDPEEALKV KRSTGTVANY QRGKKISTME ILELPVDILV PAAIEEVITD 

       310        320        330        340        350        360 
ENADRIKAKI ISEGANGPTT TAAEKILVKK GVLVLPDILA NAGGVIMSHI EWVNNRMGGW 

       370        380        390        400        410 
ITDEEALKKL EQKMVENTKT VITYWEKNLK PEENSLRDAA YMIAVERVFR AMKLRGWI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA80383.2.
PIRA72616.
RefSeqNP_147912.2. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YC65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_1386.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA80383; BAA80383; APE_1386.1.
GeneID1445984.
KEGGape:APE_1386.1.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0334.
HOGENOMHOG000243801.
KOK00261.

Enzyme and pathway databases

BioCycAPER272557:GJD6-944-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE3_AERPE
AccessionPrimary (citable) accession number: Q9YC65
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families