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Protein

Glutamate dehydrogenase

Gene

gdhA

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi217 – 2237NADSequence Analysis

GO - Molecular functioni

  1. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciAPER272557:GJD6-944-MONOMER.
BRENDAi1.4.1.4. 171.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase (EC:1.4.1.3)
Short name:
GDH
Gene namesi
Name:gdhA
Ordered Locus Names:APE_1386.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Glutamate dehydrogenasePRO_0000182754Add
BLAST

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi272557.APE_1386.1.

Structurei

3D structure databases

ProteinModelPortaliQ9YC65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243801.
KOiK00261.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YC65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPTDPLEEA RAQLRRAVDL LGYDDYVYEV LANPDRVLQV RVTIKMDDGT
60 70 80 90 100
VKTFLGWRSQ HNSALGPYKG GVRYHPNVTM NEVIALSMWM TWKNSLAGLP
110 120 130 140 150
YGGGKGGVRV NPKILSPREL ELLSRKYFES ISDIVGVDQD IPAPDVYTDP
160 170 180 190 200
QVMSWFLDEY NRVKRGQFFG VVTGKPVELG GLNARIVSTG YGVAVSTRVA
210 220 230 240 250
AEKFLGGLEG RTVAVQGYGN VGYYAAKFLA EMGAKIVAVS DSRGGIYDPE
260 270 280 290 300
GIDPEEALKV KRSTGTVANY QRGKKISTME ILELPVDILV PAAIEEVITD
310 320 330 340 350
ENADRIKAKI ISEGANGPTT TAAEKILVKK GVLVLPDILA NAGGVIMSHI
360 370 380 390 400
EWVNNRMGGW ITDEEALKKL EQKMVENTKT VITYWEKNLK PEENSLRDAA
410
YMIAVERVFR AMKLRGWI
Length:418
Mass (Da):46,171
Last modified:June 26, 2007 - v2
Checksum:i7C0A806BB62CA6E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80383.2.
PIRiA72616.
RefSeqiNP_147912.2. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80383; BAA80383; APE_1386.1.
GeneIDi1445984.
KEGGiape:APE_1386.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80383.2.
PIRiA72616.
RefSeqiNP_147912.2. NC_000854.2.

3D structure databases

ProteinModelPortaliQ9YC65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_1386.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA80383; BAA80383; APE_1386.1.
GeneIDi1445984.
KEGGiape:APE_1386.1.

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243801.
KOiK00261.

Enzyme and pathway databases

BioCyciAPER272557:GJD6-944-MONOMER.
BRENDAi1.4.1.4. 171.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiDHE3_AERPE
AccessioniPrimary (citable) accession number: Q9YC65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 26, 2007
Last modified: April 1, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.