Reviewed, UniProtKB/Swiss-Prot Q9YC65 (DHE3_AERPE)

Names and origin

Protein names

Recommended name:
    Glutamate dehydrogenase
      Short name=GDH
    EC=1.4.1.3

Gene names

Name:	gdhA
Ordered Locus Names:	APE_1386.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H.
Subunit structure	Homohexamer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Glutamate dehydrogenase		PRO_0000182754
Regions
	Nucleotide binding	217 – 223	7	NAD Potential
Sites
	Active site	105	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9YC65-1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 7C0A806BB62CA6E5	FASTA	418	46,171
	10 20 30 40 50 60 MQPTDPLEEA RAQLRRAVDL LGYDDYVYEV LANPDRVLQV RVTIKMDDGT VKTFLGWRSQ 70 80 90 100 110 120 HNSALGPYKG GVRYHPNVTM NEVIALSMWM TWKNSLAGLP YGGGKGGVRV NPKILSPREL 130 140 150 160 170 180 ELLSRKYFES ISDIVGVDQD IPAPDVYTDP QVMSWFLDEY NRVKRGQFFG VVTGKPVELG 190 200 210 220 230 240 GLNARIVSTG YGVAVSTRVA AEKFLGGLEG RTVAVQGYGN VGYYAAKFLA EMGAKIVAVS 250 260 270 280 290 300 DSRGGIYDPE GIDPEEALKV KRSTGTVANY QRGKKISTME ILELPVDILV PAAIEEVITD 310 320 330 340 350 360 ENADRIKAKI ISEGANGPTT TAAEKILVKK GVLVLPDILA NAGGVIMSHI EWVNNRMGGW 370 380 390 400 410 ITDEEALKKL EQKMVENTKT VITYWEKNLK PEENSLRDAA YMIAVERVFR AMKLRGWI

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA80383.2.
PIR	A72616.
RefSeq	NP_147912.2.
3D structure databases
HSSP	HSSP built from PDB template 1EUZ based on UniProtKB O74024.
ModBase	Search...
Genome annotation databases
GeneID	1445984.
GenomeReviews	Gene locus APE_1386.1 in contig BA000002_GR.
KEGG	ape:APE_1386.1.
NMPDR	fig|272557.1.peg.1020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YC65.
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DHase. IPR006096. Glu/Leu/Phe/Val_DHase_C. IPR006097. Glu/Leu/Phe/Val_DHase_dimer. IPR014362. Glu_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11606:SF2. GLFV_DH. 1 hit.
Pfam	PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view]
PIRSF	PIRSF000185. Glu_DH. 1 hit.
PRINTS	PR00082. GLFDHDRGNASE.
PROSITE	PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

DHE3_AERPE

Accession

Primary (citable) accession number: Q9YC65

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 26, 2007
Last modified:	November 4, 2008
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)