Q9YBY9 (ARGB_AERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate/acetylaminoadipate kinase
EC=2.7.2.-
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Synonyms:	lysZ
Ordered Locus Names:	APE_1461.1

Organism

Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]

Taxonomic identifier

272557 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP MF_00082_A
Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_A ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate. HAMAP MF_00082_A
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_A Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5. HAMAP MF_00082_A
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_A.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW lysine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Acetylglutamate/acetylaminoadipate kinase HAMAP MF_00082_A		PRO_0000112691
Regions
	Region	42 – 43	2	Substrate binding By similarity
Sites
	Binding site	69	1	Substrate By similarity
	Binding site	177	1	Substrate By similarity
	Site	10	1	Transition state stabilizer By similarity
	Site	233	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9YBY9 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 4DF532E869187817	FASTA	270	28,838
	10 20 30 40 50 60 MARYGVAVVK IGGSIASRLE RVADEIAVLA REGLRLVVVH GGGKVVDEYS RRMGVEPRYV 70 80 90 100 110 120 LHPSGVRSRY TSWEELEVYV MVMAGLLATS ISSELASRGL KVLSLTGLDG LSVEARRRER 130 140 150 160 170 180 IVIVNERGRP QAIPGGYTGK IERVDSMFVG SMLQQVDVIL YSPVAYGREG DRVVALNVDG 190 200 210 220 230 240 DQMAASLSAA LKAPLALVTD VPGVILDGRV VDRIRVSEAR EIAAKAGVGM NRKILMAAKA 250 260 270 VSEGSPYAAI GDPPIQSLIN GEKGTLVTRS

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA80459.2.
PIR	E72625.
RefSeq	NP_147959.2. NC_000854.2.
3D structure databases
ProteinModelPortal	Q9YBY9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1446030.
GenomeReviews	Gene locus APE_1461.1 in contig BA000002_GR.
KEGG	ape:APE_1461.1.
NMPDR	fig|272557.1.peg.1067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG497643.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	APER272557:APE1461-MONOMER.
Family and domain databases
HAMAP	MF_00082_A. ArgB_A. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_AERPE

Accession

Primary (citable) accession number: Q9YBY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 26, 2007
Last modified:	November 16, 2011
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program