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Q9YBY6 (ARGD_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetylornithine/acetyl-lysine aminotransferase
Short name=ACOAT
EC=2.6.1.-
EC=2.6.1.11
Gene names
Name:argD
Synonyms:lysJ
Ordered Locus Names:APE_1464
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP MF_01107

Catalytic activity

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. HAMAP MF_01107

N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate. HAMAP MF_01107

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP MF_01107

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. HAMAP MF_01107

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5. HAMAP MF_01107

Subunit structure

Homodimer By similarity. HAMAP MF_01107

Subcellular location

Cytoplasm Probable HAMAP MF_01107.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Acetylornithine/acetyl-lysine aminotransferase HAMAP MF_01107
PRO_0000112818

Regions

Region100 – 1012Pyridoxal phosphate binding By similarity
Region211 – 2144Pyridoxal phosphate binding By similarity

Sites

Binding site1271Pyridoxal phosphate; via carbonyl oxygen By similarity
Binding site1301N2-acetyl-L-ornithine By similarity
Binding site2681N2-acetyl-L-ornithine By similarity
Binding site2691Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2401N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9YBY6 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 42FC55B19CACD15A

FASTA38841,523
        10         20         30         40         50         60 
MNVVLKFVRF YGYRGLRIVK GSMQYVWDDS GRKYLDCHAG HGAAFLGHSN PAIVEAVVRQ 

        70         80         90        100        110        120 
ARELVAASSS FSTPSLEEAL TEFSRIAPPW AEEIVFLNTG TEAVEAALKA AWLATGKRGI 

       130        140        150        160        170        180 
VALKNSFHGR TLASLSVTWN PRYRRGVPVL DTRFLSPSTD PGEVEKLVPE DTAAIIVEPI 

       190        200        210        220        230        240 
QGEGGLTKIY AELAKALREA ADRVGALLIF DEIQTGFGRT GRVWAHESLG VEPDIMTAGK 

       250        260        270        280        290        300 
SIAGGLPASA VLSREGVLAT LASGRHGSTH AANPLSMAAV AAASRFLREE GVPDKARAAG 

       310        320        330        340        350        360 
ALLEGLLRDR IEGLRLVRGV RGEGLMLGVE LRLDPGPVLR CLQESERVLA LRSGATVVRL 

       370        380 
LPPYSISRED AEMVVYGLER CICGGSGC

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000002 Genomic DNA. Translation: BAA80462.1.
PIRH72625.
RefSeqNP_147962.1. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YBY6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1446033.
GenomeReviewsGene locus APE_1464 in contig BA000002_GR.
KEGGape:APE_1464.
NMPDRfig|272557.1.peg.1070.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG725944.
OMAWLCNSGT.
PhylomeDBQ9YBY6.

Enzyme and pathway databases

BioCycAPER272557:APE1464-MONOMER.

Family and domain databases

HAMAPMF_01107. ArgD_aminotrans_3.
[Tree]
InterProIPR004636. AcOrn/SuccinylOrn_aminoTrfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KOK05830.
PANTHERPTHR11986. Aminotrans_3. 1 hit.
PTHR11986:SF19. ArgD_aminotrans. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGD_AERPE
AccessionPrimary (citable) accession number: Q9YBY6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1999
Last modified: December 14, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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