Reviewed, UniProtKB/Swiss-Prot Q9YBR1 (TPIS_AERPE)

Names and origin

Protein names

Recommended name:
    Triosephosphate isomerase
      Short name=TIM
    EC=5.3.1.1
Alternative name(s):
    Triose-phosphate isomerase

Gene names

Name:	tpiA
Ordered Locus Names:	APE_1538.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Triosephosphate isomerase HAMAP MF_00147		PRO_0000090327
Sites
	Active site	91	1	Electrophile By similarity
	Active site	139	1	Proton acceptor By similarity
	Binding site	8	1	Substrate By similarity
	Binding site	10	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9YBR1-1 [UniParc]. Last modified August 2, 2002. Version 2. Checksum: ECA156606BCB89E2	FASTA	223	23,020
	10 20 30 40 50 60 MKPVLAVNMK TYSSAFGEGA RRLARDAARV AREVDVRVIL VAPLINASSL AGVYGDVYIQ 70 80 90 100 110 120 HADPVDLGAH TGYTPVEAAA AEGLRGVMVN HSEHKVTYRH LQAVVSKARS LGLEVLACAD 130 140 150 160 170 180 TPEEAAAAAL LRPSMVALEP PELIGTGIPV SQAKPEVITR GVEAVARVAP GVAVLAGAGI 190 200 210 220 TAGEDARRAV ELGAQGVLVA SAVMKAKDPH GKMLELAEAM AKP

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA80537.2.
PIR	C72635.
RefSeq	NP_148008.2.
3D structure databases
HSSP	HSSP built from PDB template 1HG3 based on UniProtKB P95583.
ModBase	Search...
Genome annotation databases
GeneID	1446080.
GenomeReviews	Gene locus APE_1538.1 in contig BA000002_GR.
KEGG	ape:APE_1538.1.
NMPDR	fig|272557.1.peg.1116.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YBR1.
OMA	Q9YBR1. VEPPELI.
Enzyme and pathway databases
BRENDA	5.3.1.1. 256344.
Family and domain databases
HAMAP	MF_00147. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000652. Triosephosphate_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
ProDom	PD001005. Triophos_ismrse. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00419. tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS_AERPE

Accession

Primary (citable) accession number: Q9YBR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	August 2, 2002
Last modified:	June 16, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)