Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9YBQ2

- APEH_AERPE

UniProt

Q9YBQ2 - APEH_AERPE

Protein

Acylamino-acid-releasing enzyme

Gene

APE_1547.1

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.

    Catalytic activityi

    Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei445 – 4451Charge relay systemBy similarity
    Active sitei524 – 5241Charge relay systemBy similarity
    Active sitei556 – 5561Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type peptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciAPER272557:GJD6-1046-MONOMER.

    Protein family/group databases

    MEROPSiS09.070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acylamino-acid-releasing enzyme (EC:3.4.19.1)
    Short name:
    AARE
    Alternative name(s):
    Acyl-peptide hydrolase
    Short name:
    APH
    Acylaminoacyl-peptidase
    Gene namesi
    Ordered Locus Names:APE_1547.1
    OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
    Taxonomic identifieri272557 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
    ProteomesiUP000002518: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Acylamino-acid-releasing enzymePRO_0000122436Add
    BLAST

    Proteomic databases

    PRIDEiQ9YBQ2.

    Interactioni

    Protein-protein interaction databases

    STRINGi272557.APE_1547.1.

    Structurei

    Secondary structure

    1
    582
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 2113
    Beta strandi24 – 318
    Turni32 – 343
    Beta strandi35 – 428
    Beta strandi45 – 528
    Beta strandi55 – 584
    Beta strandi65 – 673
    Beta strandi75 – 828
    Beta strandi90 – 967
    Beta strandi103 – 1053
    Beta strandi111 – 1199
    Beta strandi124 – 1296
    Beta strandi134 – 1407
    Beta strandi143 – 15210
    Beta strandi154 – 1607
    Beta strandi163 – 1719
    Beta strandi174 – 1818
    Turni182 – 1843
    Beta strandi188 – 1903
    Beta strandi196 – 2027
    Beta strandi208 – 2136
    Beta strandi218 – 2236
    Turni225 – 2273
    Beta strandi230 – 2323
    Beta strandi236 – 2383
    Helixi239 – 2435
    Beta strandi246 – 2538
    Beta strandi255 – 2573
    Beta strandi259 – 2657
    Beta strandi268 – 2736
    Beta strandi276 – 2783
    Beta strandi282 – 29110
    Beta strandi294 – 3018
    Beta strandi304 – 3118
    Turni312 – 3143
    Beta strandi316 – 3183
    Helixi324 – 3285
    Beta strandi330 – 33910
    Beta strandi345 – 3539
    Beta strandi358 – 3669
    Beta strandi368 – 3714
    Helixi380 – 3878
    Beta strandi391 – 3955
    Beta strandi401 – 4033
    Helixi405 – 4095
    Turni410 – 4134
    Turni415 – 4173
    Helixi418 – 43215
    Beta strandi436 – 4449
    Helixi446 – 45712
    Beta strandi461 – 4633
    Beta strandi465 – 4695
    Helixi474 – 4796
    Helixi483 – 49210
    Turni493 – 4953
    Helixi497 – 5026
    Helixi505 – 5117
    Beta strandi516 – 5216
    Beta strandi525 – 5273
    Helixi529 – 54113
    Beta strandi546 – 5516
    Helixi561 – 57919

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VE6X-ray2.10A/B1-582[»]
    1VE7X-ray2.70A/B1-582[»]
    2HU5X-ray2.00A/B1-582[»]
    2HU7X-ray2.01A/B1-582[»]
    2HU8X-ray2.40A/B1-582[»]
    2QR5X-ray2.20A/B1-582[»]
    2QZPX-ray2.70A/B21-582[»]
    3O4GX-ray2.50A/B/C/D1-582[»]
    3O4HX-ray1.82A/B/C/D1-582[»]
    3O4IX-ray2.70A/B1-582[»]
    3O4JX-ray2.50A/B/C/D1-582[»]
    DisProtiDP00248.
    ProteinModelPortaliQ9YBQ2.
    SMRiQ9YBQ2. Positions 8-582.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9YBQ2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9C family.Curated

    Phylogenomic databases

    eggNOGiCOG1506.
    HOGENOMiHOG000115412.
    KOiK01303.
    OMAiLMDIGDP.

    Family and domain databases

    Gene3Di2.120.10.30. 2 hits.
    3.40.50.1820. 2 hits.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    [Graphical view]
    PfamiPF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9YBQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIIMPVEFS RIVRDVERLI AVEKYSLQGV VDGDKLLVVG FSEGSVNAYL    50
    YDGGETVKLN REPINSVLDP HYGVGRVILV RDVSKGAEQH ALFKVNTSRP 100
    GEEQRLEAVK PMRILSGVDT GEAVVFTGAT EDRVALYALD GGGLRELARL 150
    PGFGFVSDIR GDLIAGLGFF GGGRVSLFTS NLSSGGLRVF DSGEGSFSSA 200
    SISPGMKVTA GLETAREARL VTVDPRDGSV EDLELPSKDF SSYRPTAITW 250
    LGYLPDGRLA VVARREGRSA VFIDGERVEA PQGNHGRVVL WRGKLVTSHT 300
    SLSTPPRIVS LPSGEPLLEG GLPEDLRRSI AGSRLVWVES FDGSRVPTYV 350
    LESGRAPTPG PTVVLVHGGP FAEDSDSWDT FAASLAAAGF HVVMPNYRGS 400
    TGYGEEWRLK IIGDPCGGEL EDVSAAARWA RESGLASELY IMGYSYGGYM 450
    TLCALTMKPG LFKAGVAGAS VVDWEEMYEL SDAAFRNFIE QLTGGSREIM 500
    RSRSPINHVD RIKEPLALIH PQNDSRTPLK PLLRLMGELL ARGKTFEAHI 550
    IPDAGHAINT MEDAVKILLP AVFFLATQRE RR 582
    Length:582
    Mass (Da):63,035
    Last modified:November 1, 1999 - v1
    Checksum:iA9F2DD39ACD1C3DF
    GO

    Sequence cautioni

    The sequence BAA80546.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA80546.2. Different initiation.
    PIRiD72636.
    RefSeqiNP_148014.2. NC_000854.2.

    Genome annotation databases

    EnsemblBacteriaiBAA80546; BAA80546; APE_1547.1.
    GeneIDi1446086.
    KEGGiape:APE_1547.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA80546.2 . Different initiation.
    PIRi D72636.
    RefSeqi NP_148014.2. NC_000854.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VE6 X-ray 2.10 A/B 1-582 [» ]
    1VE7 X-ray 2.70 A/B 1-582 [» ]
    2HU5 X-ray 2.00 A/B 1-582 [» ]
    2HU7 X-ray 2.01 A/B 1-582 [» ]
    2HU8 X-ray 2.40 A/B 1-582 [» ]
    2QR5 X-ray 2.20 A/B 1-582 [» ]
    2QZP X-ray 2.70 A/B 21-582 [» ]
    3O4G X-ray 2.50 A/B/C/D 1-582 [» ]
    3O4H X-ray 1.82 A/B/C/D 1-582 [» ]
    3O4I X-ray 2.70 A/B 1-582 [» ]
    3O4J X-ray 2.50 A/B/C/D 1-582 [» ]
    DisProti DP00248.
    ProteinModelPortali Q9YBQ2.
    SMRi Q9YBQ2. Positions 8-582.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272557.APE_1547.1.

    Protein family/group databases

    MEROPSi S09.070.

    Proteomic databases

    PRIDEi Q9YBQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA80546 ; BAA80546 ; APE_1547.1 .
    GeneIDi 1446086.
    KEGGi ape:APE_1547.1.

    Phylogenomic databases

    eggNOGi COG1506.
    HOGENOMi HOG000115412.
    KOi K01303.
    OMAi LMDIGDP.

    Enzyme and pathway databases

    BioCyci APER272557:GJD6-1046-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9YBQ2.

    Family and domain databases

    Gene3Di 2.120.10.30. 2 hits.
    3.40.50.1820. 2 hits.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    [Graphical view ]
    Pfami PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.
    2. "Crystallization and preliminary crystallographic analysis of acylamino-acid releasing enzyme from the hyperthermophilic archaeon Aeropyrum pernix."
      Wang G., Gao R., Ding Y., Yang H., Cao S., Feng Y., Rao Z.
      Acta Crystallogr. D 58:1054-1055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CRYSTALLIZATION.
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

    Entry informationi

    Entry nameiAPEH_AERPE
    AccessioniPrimary (citable) accession number: Q9YBQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3