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Q9YBQ2

- APEH_AERPE

UniProt

Q9YBQ2 - APEH_AERPE

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Protein

Acylamino-acid-releasing enzyme

Gene

APE_1547.1

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.

Catalytic activityi

Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei445 – 4451Charge relay systemBy similarity
Active sitei524 – 5241Charge relay systemBy similarity
Active sitei556 – 5561Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type peptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1046-MONOMER.

Protein family/group databases

MEROPSiS09.070.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylamino-acid-releasing enzyme (EC:3.4.19.1)
Short name:
AARE
Alternative name(s):
Acyl-peptide hydrolase
Short name:
APH
Acylaminoacyl-peptidase
Gene namesi
Ordered Locus Names:APE_1547.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Acylamino-acid-releasing enzymePRO_0000122436Add
BLAST

Proteomic databases

PRIDEiQ9YBQ2.

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_1547.1.

Structurei

Secondary structure

1
582
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2113Combined sources
Beta strandi24 – 318Combined sources
Turni32 – 343Combined sources
Beta strandi35 – 428Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 584Combined sources
Beta strandi65 – 673Combined sources
Beta strandi75 – 828Combined sources
Beta strandi90 – 967Combined sources
Beta strandi103 – 1053Combined sources
Beta strandi111 – 1199Combined sources
Beta strandi124 – 1296Combined sources
Beta strandi134 – 1407Combined sources
Beta strandi143 – 15210Combined sources
Beta strandi154 – 1607Combined sources
Beta strandi163 – 1719Combined sources
Beta strandi174 – 1818Combined sources
Turni182 – 1843Combined sources
Beta strandi188 – 1903Combined sources
Beta strandi196 – 2027Combined sources
Beta strandi208 – 2136Combined sources
Beta strandi218 – 2236Combined sources
Turni225 – 2273Combined sources
Beta strandi230 – 2323Combined sources
Beta strandi236 – 2383Combined sources
Helixi239 – 2435Combined sources
Beta strandi246 – 2538Combined sources
Beta strandi255 – 2573Combined sources
Beta strandi259 – 2657Combined sources
Beta strandi268 – 2736Combined sources
Beta strandi276 – 2783Combined sources
Beta strandi282 – 29110Combined sources
Beta strandi294 – 3018Combined sources
Beta strandi304 – 3118Combined sources
Turni312 – 3143Combined sources
Beta strandi316 – 3183Combined sources
Helixi324 – 3285Combined sources
Beta strandi330 – 33910Combined sources
Beta strandi345 – 3539Combined sources
Beta strandi358 – 3669Combined sources
Beta strandi368 – 3714Combined sources
Helixi380 – 3878Combined sources
Beta strandi391 – 3955Combined sources
Beta strandi401 – 4033Combined sources
Helixi405 – 4095Combined sources
Turni410 – 4134Combined sources
Turni415 – 4173Combined sources
Helixi418 – 43215Combined sources
Beta strandi436 – 4449Combined sources
Helixi446 – 45712Combined sources
Beta strandi461 – 4633Combined sources
Beta strandi465 – 4695Combined sources
Helixi474 – 4796Combined sources
Helixi483 – 49210Combined sources
Turni493 – 4953Combined sources
Helixi497 – 5026Combined sources
Helixi505 – 5117Combined sources
Beta strandi516 – 5216Combined sources
Beta strandi525 – 5273Combined sources
Helixi529 – 54113Combined sources
Beta strandi546 – 5516Combined sources
Helixi561 – 57919Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VE6X-ray2.10A/B1-582[»]
1VE7X-ray2.70A/B1-582[»]
2HU5X-ray2.00A/B1-582[»]
2HU7X-ray2.01A/B1-582[»]
2HU8X-ray2.40A/B1-582[»]
2QR5X-ray2.20A/B1-582[»]
2QZPX-ray2.70A/B21-582[»]
3O4GX-ray2.50A/B/C/D1-582[»]
3O4HX-ray1.82A/B/C/D1-582[»]
3O4IX-ray2.70A/B1-582[»]
3O4JX-ray2.50A/B/C/D1-582[»]
DisProtiDP00248.
ProteinModelPortaliQ9YBQ2.
SMRiQ9YBQ2. Positions 8-582.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YBQ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9C family.Curated

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000115412.
KOiK01303.
OMAiLMDIGDP.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
3.40.50.1820. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
[Graphical view]
PfamiPF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YBQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIIMPVEFS RIVRDVERLI AVEKYSLQGV VDGDKLLVVG FSEGSVNAYL
60 70 80 90 100
YDGGETVKLN REPINSVLDP HYGVGRVILV RDVSKGAEQH ALFKVNTSRP
110 120 130 140 150
GEEQRLEAVK PMRILSGVDT GEAVVFTGAT EDRVALYALD GGGLRELARL
160 170 180 190 200
PGFGFVSDIR GDLIAGLGFF GGGRVSLFTS NLSSGGLRVF DSGEGSFSSA
210 220 230 240 250
SISPGMKVTA GLETAREARL VTVDPRDGSV EDLELPSKDF SSYRPTAITW
260 270 280 290 300
LGYLPDGRLA VVARREGRSA VFIDGERVEA PQGNHGRVVL WRGKLVTSHT
310 320 330 340 350
SLSTPPRIVS LPSGEPLLEG GLPEDLRRSI AGSRLVWVES FDGSRVPTYV
360 370 380 390 400
LESGRAPTPG PTVVLVHGGP FAEDSDSWDT FAASLAAAGF HVVMPNYRGS
410 420 430 440 450
TGYGEEWRLK IIGDPCGGEL EDVSAAARWA RESGLASELY IMGYSYGGYM
460 470 480 490 500
TLCALTMKPG LFKAGVAGAS VVDWEEMYEL SDAAFRNFIE QLTGGSREIM
510 520 530 540 550
RSRSPINHVD RIKEPLALIH PQNDSRTPLK PLLRLMGELL ARGKTFEAHI
560 570 580
IPDAGHAINT MEDAVKILLP AVFFLATQRE RR
Length:582
Mass (Da):63,035
Last modified:November 1, 1999 - v1
Checksum:iA9F2DD39ACD1C3DF
GO

Sequence cautioni

The sequence BAA80546.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80546.2. Different initiation.
PIRiD72636.
RefSeqiNP_148014.2. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80546; BAA80546; APE_1547.1.
GeneIDi1446086.
KEGGiape:APE_1547.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80546.2 . Different initiation.
PIRi D72636.
RefSeqi NP_148014.2. NC_000854.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VE6 X-ray 2.10 A/B 1-582 [» ]
1VE7 X-ray 2.70 A/B 1-582 [» ]
2HU5 X-ray 2.00 A/B 1-582 [» ]
2HU7 X-ray 2.01 A/B 1-582 [» ]
2HU8 X-ray 2.40 A/B 1-582 [» ]
2QR5 X-ray 2.20 A/B 1-582 [» ]
2QZP X-ray 2.70 A/B 21-582 [» ]
3O4G X-ray 2.50 A/B/C/D 1-582 [» ]
3O4H X-ray 1.82 A/B/C/D 1-582 [» ]
3O4I X-ray 2.70 A/B 1-582 [» ]
3O4J X-ray 2.50 A/B/C/D 1-582 [» ]
DisProti DP00248.
ProteinModelPortali Q9YBQ2.
SMRi Q9YBQ2. Positions 8-582.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_1547.1.

Protein family/group databases

MEROPSi S09.070.

Proteomic databases

PRIDEi Q9YBQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA80546 ; BAA80546 ; APE_1547.1 .
GeneIDi 1446086.
KEGGi ape:APE_1547.1.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000115412.
KOi K01303.
OMAi LMDIGDP.

Enzyme and pathway databases

BioCyci APER272557:GJD6-1046-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9YBQ2.

Family and domain databases

Gene3Di 2.120.10.30. 2 hits.
3.40.50.1820. 2 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
[Graphical view ]
Pfami PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.
  2. "Crystallization and preliminary crystallographic analysis of acylamino-acid releasing enzyme from the hyperthermophilic archaeon Aeropyrum pernix."
    Wang G., Gao R., Ding Y., Yang H., Cao S., Feng Y., Rao Z.
    Acta Crystallogr. D 58:1054-1055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CRYSTALLIZATION.
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiAPEH_AERPE
AccessioniPrimary (citable) accession number: Q9YBQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3