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Q9YBQ2

- APEH_AERPE

UniProt

Q9YBQ2 - APEH_AERPE

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Protein

Acylamino-acid-releasing enzyme

Gene
APE_1547.1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.

Catalytic activityi

Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei445 – 4451Charge relay system By similarity
Active sitei524 – 5241Charge relay system By similarity
Active sitei556 – 5561Charge relay system By similarity

GO - Molecular functioni

  1. serine-type peptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1046-MONOMER.

Protein family/group databases

MEROPSiS09.070.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylamino-acid-releasing enzyme (EC:3.4.19.1)
Short name:
AARE
Alternative name(s):
Acyl-peptide hydrolase
Short name:
APH
Acylaminoacyl-peptidase
Gene namesi
Ordered Locus Names:APE_1547.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Acylamino-acid-releasing enzymePRO_0000122436Add
BLAST

Proteomic databases

PRIDEiQ9YBQ2.

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_1547.1.

Structurei

Secondary structure

1
582
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2113
Beta strandi24 – 318
Turni32 – 343
Beta strandi35 – 428
Beta strandi45 – 528
Beta strandi55 – 584
Beta strandi65 – 673
Beta strandi75 – 828
Beta strandi90 – 967
Beta strandi103 – 1053
Beta strandi111 – 1199
Beta strandi124 – 1296
Beta strandi134 – 1407
Beta strandi143 – 15210
Beta strandi154 – 1607
Beta strandi163 – 1719
Beta strandi174 – 1818
Turni182 – 1843
Beta strandi188 – 1903
Beta strandi196 – 2027
Beta strandi208 – 2136
Beta strandi218 – 2236
Turni225 – 2273
Beta strandi230 – 2323
Beta strandi236 – 2383
Helixi239 – 2435
Beta strandi246 – 2538
Beta strandi255 – 2573
Beta strandi259 – 2657
Beta strandi268 – 2736
Beta strandi276 – 2783
Beta strandi282 – 29110
Beta strandi294 – 3018
Beta strandi304 – 3118
Turni312 – 3143
Beta strandi316 – 3183
Helixi324 – 3285
Beta strandi330 – 33910
Beta strandi345 – 3539
Beta strandi358 – 3669
Beta strandi368 – 3714
Helixi380 – 3878
Beta strandi391 – 3955
Beta strandi401 – 4033
Helixi405 – 4095
Turni410 – 4134
Turni415 – 4173
Helixi418 – 43215
Beta strandi436 – 4449
Helixi446 – 45712
Beta strandi461 – 4633
Beta strandi465 – 4695
Helixi474 – 4796
Helixi483 – 49210
Turni493 – 4953
Helixi497 – 5026
Helixi505 – 5117
Beta strandi516 – 5216
Beta strandi525 – 5273
Helixi529 – 54113
Beta strandi546 – 5516
Helixi561 – 57919

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VE6X-ray2.10A/B1-582[»]
1VE7X-ray2.70A/B1-582[»]
2HU5X-ray2.00A/B1-582[»]
2HU7X-ray2.01A/B1-582[»]
2HU8X-ray2.40A/B1-582[»]
2QR5X-ray2.20A/B1-582[»]
2QZPX-ray2.70A/B21-582[»]
3O4GX-ray2.50A/B/C/D1-582[»]
3O4HX-ray1.82A/B/C/D1-582[»]
3O4IX-ray2.70A/B1-582[»]
3O4JX-ray2.50A/B/C/D1-582[»]
DisProtiDP00248.
ProteinModelPortaliQ9YBQ2.
SMRiQ9YBQ2. Positions 8-582.

Miscellaneous databases

EvolutionaryTraceiQ9YBQ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9C family.

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000115412.
KOiK01303.
OMAiLMDIGDP.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
3.40.50.1820. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
[Graphical view]
PfamiPF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YBQ2-1 [UniParc]FASTAAdd to Basket

« Hide

MRIIMPVEFS RIVRDVERLI AVEKYSLQGV VDGDKLLVVG FSEGSVNAYL    50
YDGGETVKLN REPINSVLDP HYGVGRVILV RDVSKGAEQH ALFKVNTSRP 100
GEEQRLEAVK PMRILSGVDT GEAVVFTGAT EDRVALYALD GGGLRELARL 150
PGFGFVSDIR GDLIAGLGFF GGGRVSLFTS NLSSGGLRVF DSGEGSFSSA 200
SISPGMKVTA GLETAREARL VTVDPRDGSV EDLELPSKDF SSYRPTAITW 250
LGYLPDGRLA VVARREGRSA VFIDGERVEA PQGNHGRVVL WRGKLVTSHT 300
SLSTPPRIVS LPSGEPLLEG GLPEDLRRSI AGSRLVWVES FDGSRVPTYV 350
LESGRAPTPG PTVVLVHGGP FAEDSDSWDT FAASLAAAGF HVVMPNYRGS 400
TGYGEEWRLK IIGDPCGGEL EDVSAAARWA RESGLASELY IMGYSYGGYM 450
TLCALTMKPG LFKAGVAGAS VVDWEEMYEL SDAAFRNFIE QLTGGSREIM 500
RSRSPINHVD RIKEPLALIH PQNDSRTPLK PLLRLMGELL ARGKTFEAHI 550
IPDAGHAINT MEDAVKILLP AVFFLATQRE RR 582
Length:582
Mass (Da):63,035
Last modified:November 1, 1999 - v1
Checksum:iA9F2DD39ACD1C3DF
GO

Sequence cautioni

The sequence BAA80546.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80546.2. Different initiation.
PIRiD72636.
RefSeqiNP_148014.2. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80546; BAA80546; APE_1547.1.
GeneIDi1446086.
KEGGiape:APE_1547.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA80546.2 . Different initiation.
PIRi D72636.
RefSeqi NP_148014.2. NC_000854.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VE6 X-ray 2.10 A/B 1-582 [» ]
1VE7 X-ray 2.70 A/B 1-582 [» ]
2HU5 X-ray 2.00 A/B 1-582 [» ]
2HU7 X-ray 2.01 A/B 1-582 [» ]
2HU8 X-ray 2.40 A/B 1-582 [» ]
2QR5 X-ray 2.20 A/B 1-582 [» ]
2QZP X-ray 2.70 A/B 21-582 [» ]
3O4G X-ray 2.50 A/B/C/D 1-582 [» ]
3O4H X-ray 1.82 A/B/C/D 1-582 [» ]
3O4I X-ray 2.70 A/B 1-582 [» ]
3O4J X-ray 2.50 A/B/C/D 1-582 [» ]
DisProti DP00248.
ProteinModelPortali Q9YBQ2.
SMRi Q9YBQ2. Positions 8-582.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_1547.1.

Protein family/group databases

MEROPSi S09.070.

Proteomic databases

PRIDEi Q9YBQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA80546 ; BAA80546 ; APE_1547.1 .
GeneIDi 1446086.
KEGGi ape:APE_1547.1.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000115412.
KOi K01303.
OMAi LMDIGDP.

Enzyme and pathway databases

BioCyci APER272557:GJD6-1046-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9YBQ2.

Family and domain databases

Gene3Di 2.120.10.30. 2 hits.
3.40.50.1820. 2 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
[Graphical view ]
Pfami PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.
  2. "Crystallization and preliminary crystallographic analysis of acylamino-acid releasing enzyme from the hyperthermophilic archaeon Aeropyrum pernix."
    Wang G., Gao R., Ding Y., Yang H., Cao S., Feng Y., Rao Z.
    Acta Crystallogr. D 58:1054-1055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CRYSTALLIZATION.
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiAPEH_AERPE
AccessioniPrimary (citable) accession number: Q9YBQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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