Reviewed, UniProtKB/Swiss-Prot Q9YBD6 (PTH_AERPE)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase
      Short name=PTH
    EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	APE_1661

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00628
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00628
Subcellular location	Cytoplasm By similarity HAMAP MF_00628.
Sequence similarities	Belongs to the PTH2 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 124	124	Peptidyl-tRNA hydrolase HAMAP MF_00628		PRO_0000120287

Sequences

	Sequence		Length	Mass (Da)
	Q9YBD6-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 5AA6F0E1CEB576CC	FASTA	124	13,462
	10 20 30 40 50 60 MTGEGYKQAI VVRRDLGMGR GKAAAQAAHA SCEAVFLILE SGRPEWRRWL EMWRLQGQAK 70 80 90 100 110 120 VVLRVESLAE LQEVYSKAVE EGLPASFVRD AGKTQLEPGT PTAAAVGPAP SRLVDRITGG LKLF

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA80662.1.
PIR	A72547.
RefSeq	NP_148083.1.
3D structure databases
SMR	Q9YBD6. Positions 3-124.
ModBase	Search...
Genome annotation databases
GeneID	1446157.
GenomeReviews	Gene locus APE_1661 in contig BA000002_GR.
KEGG	ape:APE_1661.
NMPDR	fig|272557.1.peg.1191.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG526257.
OMA	IQRRNPE.
Enzyme and pathway databases
BioCyc	APER272557:APE1661-MONOMER.
BRENDA	3.1.1.29. 256344.
Family and domain databases
HAMAP	MF_00628. Pept_tRNA_hydro_arch. [Tree]
InterPro	IPR002833. Pep_tRNA_hydro_PTH2. [Graphical view]
Pfam	PF01981. PTH2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00283. Pep_tRNA_hydro_PTH2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTH_AERPE

Accession

Primary (citable) accession number: Q9YBD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)