Reviewed, UniProtKB/Swiss-Prot Q9YBD6 (PTH_AERPE)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase
      Short name=PTH
    EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	APE_1661

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00628
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH2 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 124	124	Peptidyl-tRNA hydrolase HAMAP MF_00628		PRO_0000120287

Sequences

	Sequence		Length	Mass (Da)
	Q9YBD6-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 5AA6F0E1CEB576CC	FASTA	124	13,462
	10 20 30 40 50 60 MTGEGYKQAI VVRRDLGMGR GKAAAQAAHA SCEAVFLILE SGRPEWRRWL EMWRLQGQAK 70 80 90 100 110 120 VVLRVESLAE LQEVYSKAVE EGLPASFVRD AGKTQLEPGT PTAAAVGPAP SRLVDRITGG LKLF

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA80662.1.
PIR	A72547.
RefSeq	NP_148083.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1446157.
GenomeReviews	Gene locus APE_1661 in contig BA000002_GR.
KEGG	ape:APE_1661.
NMPDR	fig|272557.1.peg.1191.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YBD6.
OMA	IQRRNPE.
Enzyme and pathway databases
BRENDA	3.1.1.29. 256344.
Family and domain databases
HAMAP	MF_00628. [Tree]
InterPro	IPR002833. Pep_tRNA_hydro_PTH2. [Graphical view]
Pfam	PF01981. PTH2. 1 hit. [Graphical view]
ProDom	PD010667. UPF0099. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00283. Pep_tRNA_hydro_PTH2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTH_AERPE

Accession

Primary (citable) accession number: Q9YBD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)