ID   PYRB_AERPE              Reviewed;         308 AA.
AC   Q9YBD4;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   03-MAR-2009, entry version 50.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=APE_1663.1;
OS   Aeropyrum pernix.
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=56636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K1;
RX   MEDLINE=99310339; PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y.,
RA   Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H.,
RA   Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H.,
RA   Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y.,
RA   Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y.,
RA   Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic
RT   crenarchaeon, Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SUBUNIT: Heterooligomer of catalytic and regulatory chains.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; BA000002; BAA80664.2; -; Genomic_DNA.
DR   PIR; C72547; C72547.
DR   RefSeq; NP_148085.2; -.
DR   HSSP; P00479; 3CSU.
DR   GeneID; 1446159; -.
DR   GenomeReviews; BA000002_GR; APE_1663.1.
DR   KEGG; ape:APE_1663.1; -.
DR   NMPDR; fig|272557.1.peg.1193; -.
DR   HOGENOM; Q9YBD4; -.
DR   BRENDA; 2.1.3.2; 256344.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    308       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000113242.
SQ   SEQUENCE   308 AA;  34377 MW;  9494214D4C8E2C14 CRC64;
     MAGNPFKGRD VISITDFTRG DLELLFRQAD VIESKAGSKP LDGKVVALAF FEPSTRTRLS
     FETAVKRLGG STLLISGEEA ISVAKGENLA DTITMLDSYA DAIVIRHRYE GAALYAAEVA
     EKPVINGGDG RQHHPTQAML DLYTVYSLFG TVDGLTYGVL GDLRYGRAAS SFILGLSLFN
     PRHVYLISPP QLRARREVLE ALEKRGVPYT EVERLQDVLG ELDVLYVTRI QKERIPDPRE
     YESLRGSYRV TLDLLESFAK ESLKVLHPLP RVDEIDFSVD SSRYQAYFTQ ARLGVRVRMA
     LMNLVMRG
//