Q9YBD4 (PYRB_AERPE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 66.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Aspartate carbamoyltransferase EC=2.1.3.2 Alternative name(s): Aspartate transcarbamylase Short name=ATCase | ||||
| Gene names |
| ||||
| Organism | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 272557 [NCBI] | ||||
| Taxonomic lineage | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum |
Protein attributes
| Sequence length | 308 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001 |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001 |
| Subunit structure | Heterooligomer of catalytic and regulatory chains. |
| Sequence similarities | Belongs to the ATCase/OTCase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic processInferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 308 | 308 | Aspartate carbamoyltransferase HAMAP MF_00001 | PRO_0000113242 | |||
Sequences
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References
| [1] | "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. Kikuchi H.DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000002 Genomic DNA. Translation: BAA80664.2. |
| PIR | C72547. |
| RefSeq | NP_148085.2. NC_000854.2. |
3D structure databases | |
| ProteinModelPortal | Q9YBD4. |
| SMR | Q9YBD4. Positions 5-306. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1446159. |
| GenomeReviews | Gene locus APE_1663.1 in contig BA000002_GR. |
| KEGG | ape:APE_1663.1. |
| NMPDR | fig|272557.1.peg.1193. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG579429. |
| ProtClustDB | PRK00856. |
Enzyme and pathway databases | |
| BioCyc | APER272557:APE1663-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00001. Asp_carb_tr. [Tree] |
| InterPro | IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view] |
| KO | K00609. |
| Pfam | PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view] |
| PRINTS | PR00100. AOTCASE. PR00101. ATCASE. |
| SUPFAM | SSF53671. Asp/Orn_carbamoyltranf. 1 hit. |
| TIGRFAMs | TIGR00670. Asp_carb_tr. 1 hit. |
| PROSITE | PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRB_AERPE | ||||||||
| Accession | Primary (citable) accession number: Q9YBD4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with