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Reviewed, UniProtKB/Swiss-Prot Q9YBD4 (PYRB_AERPE)

Last modified March 3, 2009. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase
Gene names
Name: pyrB
Ordered Locus Names: APE_1663.1
OrganismAeropyrum pernix [Complete proteome] [HAMAP]
Taxonomic identifier56636 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6. HAMAP MF_00001

Subunit structure

Heterooligomer of catalytic and regulatory chains. HAMAP MF_00001

Sequence similarities

Belongs to the ATCase/OTCase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Aspartate carbamoyltransferase HAMAP MF_00001
PRO_0000113242

Sequences

Sequence LengthMass (Da)Tools
Q9YBD4-1 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: 9494214D4C8E2C14

FASTA30834,377
        10         20         30         40         50         60 
MAGNPFKGRD VISITDFTRG DLELLFRQAD VIESKAGSKP LDGKVVALAF FEPSTRTRLS 

        70         80         90        100        110        120 
FETAVKRLGG STLLISGEEA ISVAKGENLA DTITMLDSYA DAIVIRHRYE GAALYAAEVA 

       130        140        150        160        170        180 
EKPVINGGDG RQHHPTQAML DLYTVYSLFG TVDGLTYGVL GDLRYGRAAS SFILGLSLFN 

       190        200        210        220        230        240 
PRHVYLISPP QLRARREVLE ALEKRGVPYT EVERLQDVLG ELDVLYVTRI QKERIPDPRE 

       250        260        270        280        290        300 
YESLRGSYRV TLDLLESFAK ESLKVLHPLP RVDEIDFSVD SSRYQAYFTQ ARLGVRVRMA 


LMNLVMRG 

« Hide

References

[1]"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1."
Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. expand/collapse author list , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.
DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K1.

Cross-references

Sequence databases

BA000002 Genomic DNA. Translation: BAA80664.2.
PIRC72547.
RefSeqNP_148085.2.

3D structure databases

HSSPHSSP built from PDB template 3CSU based on UniProtKB P00479.
ModBaseSearch...

Genome annotation databases

GeneID1446159.
GenomeReviewsGene locus APE_1663.1 in contig BA000002_GR.
KEGGape:APE_1663.1.
NMPDRfig|272557.1.peg.1193.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9YBD4.

Enzyme and pathway databases

BRENDA2.1.3.2. 256344.

Family and domain databases

HAMAPMF_00001.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P_bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn_bd.
IPR002082. Aspartate_carbamoyltransf_euk.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00101. ATCASE.
TIGRFAMsTIGR00670. asp_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRB_AERPE
AccessionPrimary (citable) accession number: Q9YBD4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 26, 2007
Last modified: March 3, 2009
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents