Q9YBA2 (GCST_AERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	APE_1695.1

Organism

Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]

Taxonomic identifier

272557 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Probable aminomethyltransferase HAMAP MF_00259		PRO_0000122620

Sequences

	Sequence		Length	Mass (Da)
	Q9YBA2 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: A1F809E5FA785EA9	FASTA	375	41,261
	10 20 30 40 50 60 MPVRRHILED LHRSLGATFG EFAGWSVPMS YEGTLKEHMA VRREAGIFDI SHMGRMIVSG 70 80 90 100 110 120 EGATELLERI YTKRVSKTKV GFMSGPTLAL NEYARVKDDE MPYRLGEEEW LIVPNAAVAD 130 140 150 160 170 180 AMLEYFSSIA SSMGLNVSIR DLRERYALLA LQGPGAARVM EEMGGGDLLD LKPLQFRENA 190 200 210 220 230 240 GIAGVTAYIV SRSGWTGEDG FEIIAEVEAA KRIFKAAVEA GAKPAGIAAR DTLRIEAGFV 250 260 270 280 290 300 LGGHEYGEDP LRWPCAVSLR YGLGAIDWGK KGFVGEAALR ACRREGVRWI RVGLVMKKKY 310 320 330 340 350 360 ARMIPRSGYR LYVDDVDVGW VTSGTFSPVI GRGVAQAYID SRYAYIGDTI EVDVRGKRGE 370 ARLQEFPLVP LGSRG

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA80696.2.
PIR	C72551.
RefSeq	NP_148104.2. NC_000854.2.
3D structure databases
ProteinModelPortal	Q9YBA2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1446178.
GenomeReviews	Gene locus APE_1695.1 in contig BA000002_GR.
KEGG	ape:APE_1695.1.
NMPDR	fig|272557.1.peg.1212.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	DAIANDC.
PhylomeDB	Q9YBA2.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	APER272557:APE1695-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_AERPE

Accession

Primary (citable) accession number: Q9YBA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	December 14, 2011
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program