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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1188-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:APE_1756
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Arginine--tRNA ligasePRO_0000151642Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_1756.

Structurei

3D structure databases

ProteinModelPortaliQ9YB39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi129 – 13911"HIGH" regionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247213.
KOiK01887.
OMAiVGFGTMM.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YB39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSIDPLTR LHGILSSYLS EVLGVDRSVV ERLLAPPPRK EYGDLGFPLM
60 70 80 90 100
RFARSSNASA DSIVESLRGK LWERGITWAS PTLEAGYLNI VFDVEKLGDE
110 120 130 140 150
VFRLLASGWR PSTARTSRPE TIVVEHTSAN PIHPLHLGHA RNSSLGDALA
160 170 180 190 200
RLLEARGHRV NRRFYVDDVG RQAVVASLGF KLSGVTPREL ASRMGVKVDH
210 220 230 240 250
AVGWVYAVTH NALETVTARK RGDTSKVDEA LSTLARLKER GDREVFDRIL
260 270 280 290 300
EAVGSLDDPE GLVSEMMRKY ERGEEPEKSL IRGVVSAVLE GFRETLGRFG
310 320 330 340 350
VDFDDWDWES DLLWSGLVNK IIEEARRSPF LTTHKDAIAL DIPRIVREVL
360 370 380 390 400
ARDPEAASTI KLPRSLEIPP LILVRSDGTT LYTTRDLAYS VYKFRVTGAD
410 420 430 440 450
RVINVIGADQ RLPQLQIRLA LLGLGYRREA LNMMHYDYEI VSLPGRRMSS
460 470 480 490 500
RRGEYVTLDE LLEMAKARSV REVESRNPGA DRDWIESTAE KIAVGAVRFA
510 520 530 540 550
LVRPGRLKPI TLDVERILDL KENTAPYLQY TYARASSILE KHGEIDYLKA
560 570 580 590 600
HPASLEEGSR RELFVEALRF PLVSAKAADD LAPEDLASYL LRLADMFNSW
610 620 630 640
YQKDSVIHEE WEGARHAKAA LVLLVKSVIG EGLRLLGVEP LEKM
Length:644
Mass (Da):72,173
Last modified:November 1, 1999 - v1
Checksum:i076E18F55C0B5A08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80759.1.
PIRiB72559.
RefSeqiNP_148147.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA80759; BAA80759; APE_1756.
GeneIDi1446221.
KEGGiape:APE_1756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80759.1.
PIRiB72559.
RefSeqiNP_148147.1. NC_000854.2.

3D structure databases

ProteinModelPortaliQ9YB39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_1756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA80759; BAA80759; APE_1756.
GeneIDi1446221.
KEGGiape:APE_1756.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247213.
KOiK01887.
OMAiVGFGTMM.

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1188-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiSYR_AERPE
AccessioniPrimary (citable) accession number: Q9YB39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: April 29, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.