Q9YB39 (SYR_AERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	APE_1756

Organism

Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]

Taxonomic identifier

272557 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum › Aeropyrum pernix

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 644	644	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_0000151642
Regions
	Motif	129 – 139	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q9YB39 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 076E18F55C0B5A08	FASTA	644	72,173
	10 20 30 40 50 60 MASSIDPLTR LHGILSSYLS EVLGVDRSVV ERLLAPPPRK EYGDLGFPLM RFARSSNASA 70 80 90 100 110 120 DSIVESLRGK LWERGITWAS PTLEAGYLNI VFDVEKLGDE VFRLLASGWR PSTARTSRPE 130 140 150 160 170 180 TIVVEHTSAN PIHPLHLGHA RNSSLGDALA RLLEARGHRV NRRFYVDDVG RQAVVASLGF 190 200 210 220 230 240 KLSGVTPREL ASRMGVKVDH AVGWVYAVTH NALETVTARK RGDTSKVDEA LSTLARLKER 250 260 270 280 290 300 GDREVFDRIL EAVGSLDDPE GLVSEMMRKY ERGEEPEKSL IRGVVSAVLE GFRETLGRFG 310 320 330 340 350 360 VDFDDWDWES DLLWSGLVNK IIEEARRSPF LTTHKDAIAL DIPRIVREVL ARDPEAASTI 370 380 390 400 410 420 KLPRSLEIPP LILVRSDGTT LYTTRDLAYS VYKFRVTGAD RVINVIGADQ RLPQLQIRLA 430 440 450 460 470 480 LLGLGYRREA LNMMHYDYEI VSLPGRRMSS RRGEYVTLDE LLEMAKARSV REVESRNPGA 490 500 510 520 530 540 DRDWIESTAE KIAVGAVRFA LVRPGRLKPI TLDVERILDL KENTAPYLQY TYARASSILE 550 560 570 580 590 600 KHGEIDYLKA HPASLEEGSR RELFVEALRF PLVSAKAADD LAPEDLASYL LRLADMFNSW 610 620 630 640 YQKDSVIHEE WEGARHAKAA LVLLVKSVIG EGLRLLGVEP LEKM

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA80759.1.
PIR	B72559.
RefSeq	NP_148147.1. NC_000854.2.
3D structure databases
ProteinModelPortal	Q9YB39.
ModBase	Search...
Protein-protein interaction databases
STRING	272557.APE_1756.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA80759; BAA80759; APE_1756.
GeneID	1446221.
KEGG	ape:APE_1756.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247213.
KO	K01887.
OMA	VHPLHIG.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	APER272557:GJD6-1188-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 2 hits.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 2 hits. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_AERPE

Accession

Primary (citable) accession number: Q9YB39

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program