Reviewed, UniProtKB/Swiss-Prot Q9YAW4 (GYAR_AERPE)

Names and origin

Protein names

Recommended name:
    Glyoxylate reductase
    EC=1.1.1.26

Gene names

Name:	gyaR
Ordered Locus Names:	APE_1831.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Glycolate + NAD+ = glyoxylate + NADH. HAMAP MF_00776
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro glyoxylate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Glyoxylate reductase HAMAP MF_00776		PRO_0000075946
Regions
	Nucleotide binding	159 – 162	4	NADP By similarity
	Nucleotide binding	181 – 183	3	NADP By similarity
	Nucleotide binding	240 – 242	3	NADP By similarity
	Nucleotide binding	290 – 292	3	NADP By similarity
Sites
	Active site	242	1	By similarity
	Active site	271	1	By similarity
	Active site	290	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9YAW4-1 [UniParc]. Last modified May 10, 2004. Version 2. Checksum: 0CD5EE38E1AA6163	FASTA	335	37,757
	10 20 30 40 50 60 MKRPRVFVTR EVFPEALELL SKYYDVEVWD KYQPPPYETL LSKAREADAL YTLLTDRIDC 70 80 90 100 110 120 DLLSQAPRLR IVAQMAVGFD NIDVECATRL GIYVTNTPGV LTEATAEFTW ALILAAARRV 130 140 150 160 170 180 VEADHFVRWG EWWRLRTGWH PMMMLGVELR GKTLGILGMG RIGSRVAEIG KAFGMRIIYH 190 200 210 220 230 240 SRSRKREIEK ELGAEYRSLE DLLRESDILS IHLPLTDETR HLIGESELKL MKKTAILVNT 250 260 270 280 290 300 GRGAIVDTGA LVKALREGWI AAAALDVFEE EPLNPNHPLT AFKNVVLAPH AASATRETRL 310 320 330 RMAMMAAENL VAFAQGKVPP NLVNREVVKV RQPGF

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA80834.2.
PIR	E72568.
RefSeq	NP_148197.2.
3D structure databases
HSSP	HSSP built from PDB template 1HL3 based on UniProtKB Q9Z2F5.
ModBase	Search...
Genome annotation databases
GeneID	1446271.
GenomeReviews	Gene locus APE_1831.1 in contig BA000002_GR.
KEGG	ape:APE_1831.1.
NMPDR	fig|272557.1.peg.1305.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YAW4.
OMA	Q9YAW4. DHIDVKY.
Enzyme and pathway databases
BRENDA	1.1.1.26. 256344.
Family and domain databases
HAMAP	MF_00776. [Tree]
InterPro	IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GYAR_AERPE

Accession

Primary (citable) accession number: Q9YAW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	June 16, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)