Reviewed,
UniProtKB/Swiss-Prot Q9YAW4 (GYAR_AERPE)
Last modified
June 16, 2009.
Version 49.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glyoxylate reductase EC=1.1.1.26 | ||||
| Gene names |
| ||||
| Organism | Aeropyrum pernix [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 56636 [NCBI] | ||||
| Taxonomic lineage | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum |
Protein attributes
| Sequence length | 335 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Glycolate + NAD+ = glyoxylate + NADH. HAMAP MF_00776 |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NAD or NADH binding Inferred from electronic annotation. Source: InterPro glyoxylate reductase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 335 | 335 | Glyoxylate reductase HAMAP MF_00776 | PRO_0000075946 | |||||
Regions | |||||||||
| Nucleotide binding | 159 – 162 | 4 | NADP By similarity | ||||||
| Nucleotide binding | 181 – 183 | 3 | NADP By similarity | ||||||
| Nucleotide binding | 240 – 242 | 3 | NADP By similarity | ||||||
| Nucleotide binding | 290 – 292 | 3 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 242 | 1 | By similarity | ||||||
| Active site | 271 | 1 | By similarity | ||||||
| Active site | 290 | 1 | Proton donor By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. Kikuchi H.DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1. |
Cross-references
Sequence databases | |
|---|---|
| BA000002 Genomic DNA. Translation: BAA80834.2. | |
| PIR | E72568. |
| RefSeq | NP_148197.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HL3 based on UniProtKB Q9Z2F5. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1446271. |
| GenomeReviews | Gene locus APE_1831.1 in contig BA000002_GR. |
| KEGG | ape:APE_1831.1. |
| NMPDR | fig|272557.1.peg.1305. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q9YAW4. |
| OMA | Q9YAW4. DHIDVKY. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.26. 256344. |
Family and domain databases | |
| HAMAP | MF_00776. [Tree] |
| InterPro | IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view] |
| PROSITE | PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GYAR_AERPE | ||||||||
| Accession | Primary (citable) accession number: Q9YAW4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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