Q9YAW4 (GYAR_AERPE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 76.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Glyoxylate reductase EC=1.1.1.26 | ||||
| Gene names |
| ||||
| Organism | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 272557 [NCBI] | ||||
| Taxonomic lineage | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum › ![]() |
Protein attributes
| Sequence length | 335 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Glycolate + NAD+ = glyoxylate + NADH. HAMAP-Rule MF_00776 |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | NAD binding Inferred from electronic annotation. Source: InterPro glyoxylate reductase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 335 | 335 | Glyoxylate reductase HAMAP-Rule MF_00776 | PRO_0000075946 | |||||
Regions | |||||||||
| Nucleotide binding | 159 – 162 | 4 | NADP By similarity | ||||||
| Nucleotide binding | 181 – 183 | 3 | NADP By similarity | ||||||
| Nucleotide binding | 240 – 242 | 3 | NADP By similarity | ||||||
| Nucleotide binding | 290 – 292 | 3 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 242 | 1 | By similarity | ||||||
| Active site | 271 | 1 | By similarity | ||||||
| Active site | 290 | 1 | Proton donor By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. Kikuchi H.DNA Res. 6:83-101(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000002 Genomic DNA. Translation: BAA80834.2. |
| PIR | E72568. |
| RefSeq | NP_148197.2. NC_000854.2. |
3D structure databases | |
| ProteinModelPortal | Q9YAW4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 272557.APE_1831.1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | BAA80834; BAA80834; APE_1831.1. |
| GeneID | 1446271. |
| KEGG | ape:APE_1831.1. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1052. |
| HOGENOM | HOG000136700. |
| KO | K00015. |
| OMA | CERLDDL. |
| ProtClustDB | PRK13243. |
Enzyme and pathway databases | |
| BioCyc | APER272557:GJD6-1235-MONOMER. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 2 hits. |
| HAMAP | MF_00776. GyaR. |
| InterPro | IPR006139. D-isomer_2_OHA_DH_cat_dom. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR023519. Glyoxylate_reductase_GyaR. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Pfam | PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view] |
| PROSITE | PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GYAR_AERPE | ||||||||
| Accession | Primary (citable) accession number: Q9YAW4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
