ID   HMDH_AERPE              Reviewed;         421 AA.
AC   Q9YAS4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase;
DE            Short=HMG-CoA reductase;
DE            EC=1.1.1.34;
GN   Name=hmgA; OrderedLocusNames=APE_1869;
OS   Aeropyrum pernix.
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=56636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K1;
RX   MEDLINE=99310339; PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y.,
RA   Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H.,
RA   Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H.,
RA   Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y.,
RA   Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y.,
RA   Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic
RT   crenarchaeon, Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Converts HMG-CoA to mevalonate (By similarity).
CC   -!- CATALYTIC ACTIVITY: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-
CC       hydroxy-3-methylglutaryl-CoA + 2 NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; mevalonic acid
CC       biosynthesis; (R)-mevalonic acid from acetyl-CoA: step 3/3.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
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DR   EMBL; BA000002; BAA80874.1; -; Genomic_DNA.
DR   PIR; E72573; E72573.
DR   RefSeq; NP_148225.1; -.
DR   HSSP; P04035; 1HWI.
DR   GeneID; 1446303; -.
DR   GenomeReviews; BA000002_GR; APE_1869.
DR   KEGG; ape:APE_1869; -.
DR   NMPDR; fig|272557.1.peg.1333; -.
DR   HOGENOM; Q9YAS4; -.
DR   OMA; Q9YAS4; AHFANII.
DR   BRENDA; 1.1.1.34; 256344.
DR   GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH)...; IEA:EC.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002202; HMG_CoA_Rdtase_cat.
DR   InterPro; IPR004554; HMG_CoA_Rdtase_I_cat.
DR   Gene3D; G3DSA:3.90.770.10; HMG-CoA_red; 1.
DR   PANTHER; PTHR10572; HMG-CoA_red; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   TIGRFAMs; TIGR00533; HMG_CoA_R_NADP; 1.
DR   PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR   PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR   PROSITE; PS01192; HMG_COA_REDUCTASE_3; FALSE_NEG.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isoprene biosynthesis; NADP; Oxidoreductase.
FT   CHAIN         1    421       3-hydroxy-3-methylglutaryl-coenzyme A
FT                                reductase.
FT                                /FTId=PRO_0000114458.
FT   ACT_SITE    109    109       Charge relay system (By similarity).
FT   ACT_SITE    240    240       Charge relay system (By similarity).
FT   ACT_SITE    315    315       Charge relay system (By similarity).
FT   ACT_SITE    410    410       Proton donor (By similarity).
SQ   SEQUENCE   421 AA;  44625 MW;  9F67AF57FA651822 CRC64;
     MGSSSGQKPR RLEDLVDKLA SGSLSHSRLE KELGNANEAA LVRRLYLERL TGASLSSVAS
     TILDFQELYG RNIENPIGAV QVPVGVAGPL RINGDYARGD FYIPLATTEG ALVASVNRGA
     KAITLSGGAR AKVIKDGMTR APLLWTPSVY EAHRLAMWVE DRIEDLRSVV AGVTRHGRLQ
     HIYPYIIGNL VWLRLSFSTG DAMGMNMVTI SSDRICRYIE ENYDGDAKCI ALSGNMCTDK
     KPAAINKILG RGKYVVAEAV IKGEVVKNVL KTTPQNINLV NVTKNLLGSA AAGSHSFNAH
     FANIIAAIFI ATGQDAAQVV ESSMGYTWTE VRGEDLYISV TLPSLEVGTV GGGTRLPTQR
     ELLALLGVAG GGNPPGSNAL KLAEIIASAV LAGELNLLSA IAAGQLARAH ELLGRGGLKI
     S
//